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Giant cell aortitis.
Forensic Sci Med Pathol. 2020 May 29 [Online ahead of print]FS

Abstract

Inflammatory aortic diseases are broadly classified into three categories according to the degree of inflammation: atherosclerosis, atherosclerosis with excessive inflammation, and aortitis/periaortitis. This paper presents a case of a 39-year old man with aneurysmal dilatation of thoracic aorta and aortic valve insufficiency. The aortic wall showed thickening and wrinkled "tree bark" appearance as well as apparent scarring of the intima. Histological examination revealed intimal hyperplasia, a granulomatous/giant cell pattern in the inner tunica media, a few epithelioid macrophages, abundant chronic lymphoplasmacytic and histiocytic inflammation and discrete fibrinoid necrosis. The histological findings were indicative of Horton's disease, but no typical clinical features were present. The case illustrates the difficulties involved in diagnosing inflammatory aortic diseases where it may be challenging to arrive at a specific diagnosis despite the knowledge of medical history, and available macroscopic and histological findings.

Authors+Show Affiliations

Department of Forensic Medicine, University Hospital Ostrava, CZ-708 52, Ostrava, Czech Republic. Department of Intensive Medicine and Forensic Studies, Faculty of Medicine, Ostrava University, CZ-703 00, Ostrava, Czech Republic.Department of Forensic Medicine, University Hospital Ostrava, CZ-708 52, Ostrava, Czech Republic. The Fingerland Department of Pathology, Faculty of Medicine in Hradec Kralove, Charles University, CZ-500 03, Hradec Kralove, Czech Republic.Department of Forensic Medicine, University Hospital Ostrava, CZ-708 52, Ostrava, Czech Republic. Department of Epidemiology and Public Health, Faculty of Medicine, Ostrava University, CZ-703 00, Ostrava, Czech Republic.Department of English and American Studies, Faculty of Arts, Palacký University Olomouc, CZ-779 00, Olomouc, Czech Republic.Department of Forensic Medicine, University Hospital Ostrava, CZ-708 52, Ostrava, Czech Republic. marecova.klara@seznam.cz.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32472314

Citation

Handlos, Petr, et al. "Giant Cell Aortitis." Forensic Science, Medicine, and Pathology, 2020.
Handlos P, Uvíra M, Dokoupil M, et al. Giant cell aortitis. Forensic Sci Med Pathol. 2020.
Handlos, P., Uvíra, M., Dokoupil, M., Klabal, O., & Handlosová, K. (2020). Giant cell aortitis. Forensic Science, Medicine, and Pathology. https://doi.org/10.1007/s12024-020-00242-3
Handlos P, et al. Giant Cell Aortitis. Forensic Sci Med Pathol. 2020 May 29; PubMed PMID: 32472314.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Giant cell aortitis. AU - Handlos,Petr, AU - Uvíra,Matěj, AU - Dokoupil,Marek, AU - Klabal,Ondřej, AU - Handlosová,Klára, Y1 - 2020/05/29/ PY - 2020/02/26/accepted PY - 2020/5/31/entrez KW - Aortic aneurysm KW - Giant cell arteritis KW - Horton’s disease KW - Inflammatory aortic diseases KW - Non-infectious aortitis JF - Forensic science, medicine, and pathology JO - Forensic Sci Med Pathol N2 - Inflammatory aortic diseases are broadly classified into three categories according to the degree of inflammation: atherosclerosis, atherosclerosis with excessive inflammation, and aortitis/periaortitis. This paper presents a case of a 39-year old man with aneurysmal dilatation of thoracic aorta and aortic valve insufficiency. The aortic wall showed thickening and wrinkled "tree bark" appearance as well as apparent scarring of the intima. Histological examination revealed intimal hyperplasia, a granulomatous/giant cell pattern in the inner tunica media, a few epithelioid macrophages, abundant chronic lymphoplasmacytic and histiocytic inflammation and discrete fibrinoid necrosis. The histological findings were indicative of Horton's disease, but no typical clinical features were present. The case illustrates the difficulties involved in diagnosing inflammatory aortic diseases where it may be challenging to arrive at a specific diagnosis despite the knowledge of medical history, and available macroscopic and histological findings. SN - 1556-2891 UR - https://www.unboundmedicine.com/medline/citation/32472314/Giant_cell_aortitis L2 - https://dx.doi.org/10.1007/s12024-020-00242-3 DB - PRIME DP - Unbound Medicine ER -
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