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Spur cell anemia related to alcoholic liver cirrhosis managed without liver transplantation: a case report and literature review.
Clin J Gastroenterol. 2020 Oct; 13(5):882-890.CJ

Abstract

Spur cell anemia is an acquired hemolytic anemia associated with liver cirrhosis and is characterized by the presence of increased large red blood cells, which are covered with spike-like projections that vary in width, length, and distribution. A 26-year-old man was referred to our hospital presenting with jaundice, lower limb edema, and dyspnea. The patient was subsequently diagnosed with spur cell anemia related to alcoholic liver cirrhosis. Spur cell anemia is an independent predictor of mortality in liver cirrhosis and has been associated with extremely poor prognosis. The most effective treatment for spur cell anemia is liver transplantation. As seen in the literature, the treatment of spur cell anemia without liver transplantation is quite challenging. This report highlights the importance of management and treatment strategies, including control of fluid retention, blood transfusion, plasma diafiltration, and administration of diuretics. Our treatment strategies might be useful in patients who are not candidate of liver transplantation or patients waiting for liver transplantation.

Authors+Show Affiliations

Department of Gastroenterology, Chuno Kosei Hospital, 5-1 Wakusadori, Seki, Gifu, 501-3802, Japan. takao.miwa0505@gmail.com.Department of Tumor Pathology, Gifu University Graduate School of Medicine, Gifu, Japan.Department of Gastroenterology, Chuno Kosei Hospital, 5-1 Wakusadori, Seki, Gifu, 501-3802, Japan.Department of Gastroenterology, Chuno Kosei Hospital, 5-1 Wakusadori, Seki, Gifu, 501-3802, Japan.Department of Gastroenterology, Chuno Kosei Hospital, 5-1 Wakusadori, Seki, Gifu, 501-3802, Japan.Department of Hematology, Chuno Kosei Hospital, Gifu, Japan.Department of Gastroenterology, Chuno Kosei Hospital, 5-1 Wakusadori, Seki, Gifu, 501-3802, Japan.Department of Gastroenterology, Chuno Kosei Hospital, 5-1 Wakusadori, Seki, Gifu, 501-3802, Japan.Department of Gastroenterology, Gifu University Graduate School of Medicine, Gifu, Japan.Department of Gastroenterology, Gifu University Graduate School of Medicine, Gifu, Japan.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32472376

Citation

Miwa, Takao, et al. "Spur Cell Anemia Related to Alcoholic Liver Cirrhosis Managed Without Liver Transplantation: a Case Report and Literature Review." Clinical Journal of Gastroenterology, vol. 13, no. 5, 2020, pp. 882-890.
Miwa T, Hatano Y, Kochi T, et al. Spur cell anemia related to alcoholic liver cirrhosis managed without liver transplantation: a case report and literature review. Clin J Gastroenterol. 2020;13(5):882-890.
Miwa, T., Hatano, Y., Kochi, T., Aiba, M., Toda, K., Goto, H., Nakamura, N., Katsumura, N., Imai, K., & Shimizu, M. (2020). Spur cell anemia related to alcoholic liver cirrhosis managed without liver transplantation: a case report and literature review. Clinical Journal of Gastroenterology, 13(5), 882-890. https://doi.org/10.1007/s12328-020-01142-3
Miwa T, et al. Spur Cell Anemia Related to Alcoholic Liver Cirrhosis Managed Without Liver Transplantation: a Case Report and Literature Review. Clin J Gastroenterol. 2020;13(5):882-890. PubMed PMID: 32472376.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Spur cell anemia related to alcoholic liver cirrhosis managed without liver transplantation: a case report and literature review. AU - Miwa,Takao, AU - Hatano,Yuichiro, AU - Kochi,Takahiro, AU - Aiba,Masashi, AU - Toda,Katsuhisa, AU - Goto,Hideko, AU - Nakamura,Noriaki, AU - Katsumura,Naoki, AU - Imai,Kenji, AU - Shimizu,Masahito, Y1 - 2020/05/29/ PY - 2019/11/19/received PY - 2020/05/20/accepted PY - 2020/5/31/pubmed PY - 2020/5/31/medline PY - 2020/5/31/entrez KW - Alcoholic liver cirrhosis KW - Case report KW - Liver cirrhosis KW - Plasma diafiltration KW - Spur cell anemia SP - 882 EP - 890 JF - Clinical journal of gastroenterology JO - Clin J Gastroenterol VL - 13 IS - 5 N2 - Spur cell anemia is an acquired hemolytic anemia associated with liver cirrhosis and is characterized by the presence of increased large red blood cells, which are covered with spike-like projections that vary in width, length, and distribution. A 26-year-old man was referred to our hospital presenting with jaundice, lower limb edema, and dyspnea. The patient was subsequently diagnosed with spur cell anemia related to alcoholic liver cirrhosis. Spur cell anemia is an independent predictor of mortality in liver cirrhosis and has been associated with extremely poor prognosis. The most effective treatment for spur cell anemia is liver transplantation. As seen in the literature, the treatment of spur cell anemia without liver transplantation is quite challenging. This report highlights the importance of management and treatment strategies, including control of fluid retention, blood transfusion, plasma diafiltration, and administration of diuretics. Our treatment strategies might be useful in patients who are not candidate of liver transplantation or patients waiting for liver transplantation. SN - 1865-7265 UR - https://www.unboundmedicine.com/medline/citation/32472376/Spur_cell_anemia_related_to_alcoholic_liver_cirrhosis_managed_without_liver_transplantation:_a_case_report_and_literature_review_ L2 - https://dx.doi.org/10.1007/s12328-020-01142-3 DB - PRIME DP - Unbound Medicine ER -
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