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Multifarious roles of mTOR signaling in cognitive aging and cerebrovascular dysfunction of Alzheimer's disease.
IUBMB Life. 2020 May 30 [Online ahead of print]IL

Abstract

Age-related cognitive failure is a main devastating incident affecting even healthy people. Alzheimer's disease (AD) is the utmost common form of dementia among the geriatric community. In the pathogenesis of AD, cerebrovascular dysfunction is revealed before the beginning of the cognitive decline. Mounting proof shows a precarious impact of cerebrovascular dysregulation in the development of AD pathology. Recent studies document that the mammalian target of rapamycin (mTOR) acts as a crucial effector of cerebrovascular dysregulation in AD. The mTOR contributes to brain vascular dysfunction and subsequence cerebral blood flow deficits as well as cognitive impairment. Furthermore, mTOR causes the blood-brain barrier (BBB) breakdown in AD models. Inhibition of mTOR hyperactivity protects the BBB integrity in AD. Furthermore, mTOR drives cognitive defect and cerebrovascular dysfunction, which are greatly prevalent in AD, but the central molecular mechanisms underlying these alterations are obscure. This review represents the crucial and current research findings regarding the role of mTOR signaling in cognitive aging and cerebrovascular dysfunction in the pathogenesis of AD.

Authors+Show Affiliations

Department of Pharmacy, Southeast University, Dhaka, Bangladesh. Pharmakon Neuroscience Research Network, Dhaka, Bangladesh.Center for Neuroscience, Brain Science Institute, Korea Institute of Science and Technology, Seoul, Republic of Korea.Department of Pharmacy, Brac University, Dhaka, Bangladesh.Chitkara College of Pharmacy, Chitkara University, Patiala, India.Division of Drug Design and Medicinal Chemistry Research Lab, Department of Pharmaceutical Chemistry, Ahalia School of Pharmacy, Palakkad, India.Glocal School of Life Sciences, Glocal University, Saharanpur, India.Department of Biological Sciences, University of Limerick, Limerick, Ireland. Instituto de Ciencias Biomédicas, Universidad Autónoma de Chile, Santiago, Chile.Department of Biology, College of Science, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia.Department of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia. Pharmacology Department, Faculty of Veterinary Medicine, Suez Canal University, Ismailia, Egypt.King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia. Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32472959

Citation

Uddin, Md Sahab, et al. "Multifarious Roles of mTOR Signaling in Cognitive Aging and Cerebrovascular Dysfunction of Alzheimer's Disease." IUBMB Life, 2020.
Uddin MS, Rahman MA, Kabir MT, et al. Multifarious roles of mTOR signaling in cognitive aging and cerebrovascular dysfunction of Alzheimer's disease. IUBMB Life. 2020.
Uddin, M. S., Rahman, M. A., Kabir, M. T., Behl, T., Mathew, B., Perveen, A., Barreto, G. E., Bin-Jumah, M. N., Abdel-Daim, M. M., & Ashraf, G. M. (2020). Multifarious roles of mTOR signaling in cognitive aging and cerebrovascular dysfunction of Alzheimer's disease. IUBMB Life. https://doi.org/10.1002/iub.2324
Uddin MS, et al. Multifarious Roles of mTOR Signaling in Cognitive Aging and Cerebrovascular Dysfunction of Alzheimer's Disease. IUBMB Life. 2020 May 30; PubMed PMID: 32472959.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Multifarious roles of mTOR signaling in cognitive aging and cerebrovascular dysfunction of Alzheimer's disease. AU - Uddin,Md Sahab, AU - Rahman,Md Ataur, AU - Kabir,Md Tanvir, AU - Behl,Tapan, AU - Mathew,Bijo, AU - Perveen,Asma, AU - Barreto,George E, AU - Bin-Jumah,May N, AU - Abdel-Daim,Mohamed M, AU - Ashraf,Ghulam Md, Y1 - 2020/05/30/ PY - 2020/02/29/received PY - 2020/05/10/revised PY - 2020/05/13/accepted PY - 2020/5/31/entrez KW - Alzheimer's disease KW - blood-brain barrier KW - cerebrovascular dysfunction KW - cognitive aging KW - mTOR JF - IUBMB life JO - IUBMB Life N2 - Age-related cognitive failure is a main devastating incident affecting even healthy people. Alzheimer's disease (AD) is the utmost common form of dementia among the geriatric community. In the pathogenesis of AD, cerebrovascular dysfunction is revealed before the beginning of the cognitive decline. Mounting proof shows a precarious impact of cerebrovascular dysregulation in the development of AD pathology. Recent studies document that the mammalian target of rapamycin (mTOR) acts as a crucial effector of cerebrovascular dysregulation in AD. The mTOR contributes to brain vascular dysfunction and subsequence cerebral blood flow deficits as well as cognitive impairment. Furthermore, mTOR causes the blood-brain barrier (BBB) breakdown in AD models. Inhibition of mTOR hyperactivity protects the BBB integrity in AD. Furthermore, mTOR drives cognitive defect and cerebrovascular dysfunction, which are greatly prevalent in AD, but the central molecular mechanisms underlying these alterations are obscure. This review represents the crucial and current research findings regarding the role of mTOR signaling in cognitive aging and cerebrovascular dysfunction in the pathogenesis of AD. SN - 1521-6551 UR - https://www.unboundmedicine.com/medline/citation/32472959/Multifarious_roles_of_mTOR_signaling_in_cognitive_aging_and_cerebrovascular_dysfunction_of_Alzheimer's_disease_ L2 - https://doi.org/10.1002/iub.2324 DB - PRIME DP - Unbound Medicine ER -
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