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Scorpion venom phospholipases A2: A minireview.
Toxicon. 2020 Sep; 184:48-54.T

Abstract

Many venomous species, including snakes, bees and scorpions, contain a variety of secreted phospholipases A2 (sPLA2) that contribute to prey digestion and venom toxicity. Based on their primary structures, the different venom sPLA2 have been classified into four groups I, II, III and IX. While the structure of sPLA2 groups II and I has been well characterized, only one crystal structure of group III sPLA2 from bee venom was described. Scorpion venom sPLA2 belong to group III with a particular heterodimeric structure composed of a long enzymatic chain linked by a disulfide bridge to a Short one after the release of five residues (penta-peptide) during the maturation processes. The function of the Short chain is still not clear. Its sequence varies in composition and in length between different scorpion species. Available studies of the structure-function relationships of scorpion venom sPLA2 are limited. Some biological activities of these enzymes such as neurotoxicity, myotoxicity, along with the hemolytic, anticoagulant, anti-tumoral and anti-angiogenic activities have been investigated. In this review, we tentatively summarize the last findings about the biochemical properties, the structure-function relation and the biological activities of scorpion venom phospholipases A2. In addition to expanding the database of structures for these sPLA2 and understanding their properties and functions, this survey is intended to explore the molecular mechanisms and signaling pathways of the described biological activities.

Authors+Show Affiliations

Laboratoire de Biochimie et de Génie Enzymatique des Lipases, ENIS, Université de Sfax, Route de Soukra 3038, BP 1173, Sfax, Tunisia.Laboratoire de Biochimie et de Génie Enzymatique des Lipases, ENIS, Université de Sfax, Route de Soukra 3038, BP 1173, Sfax, Tunisia. Electronic address: ytgargouri@yahoo.fr.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32473923

Citation

Krayem, Najeh, and Youssef Gargouri. "Scorpion Venom Phospholipases A2: a Minireview." Toxicon : Official Journal of the International Society On Toxinology, vol. 184, 2020, pp. 48-54.
Krayem N, Gargouri Y. Scorpion venom phospholipases A2: A minireview. Toxicon. 2020;184:48-54.
Krayem, N., & Gargouri, Y. (2020). Scorpion venom phospholipases A2: A minireview. Toxicon : Official Journal of the International Society On Toxinology, 184, 48-54. https://doi.org/10.1016/j.toxicon.2020.05.020
Krayem N, Gargouri Y. Scorpion Venom Phospholipases A2: a Minireview. Toxicon. 2020;184:48-54. PubMed PMID: 32473923.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Scorpion venom phospholipases A2: A minireview. AU - Krayem,Najeh, AU - Gargouri,Youssef, Y1 - 2020/05/29/ PY - 2019/12/23/received PY - 2020/05/07/revised PY - 2020/05/24/accepted PY - 2020/6/1/pubmed PY - 2020/6/1/medline PY - 2020/6/1/entrez KW - Biochemical properties KW - Biological activities KW - Scorpion venom phospholipases A(2) KW - Secreted phospholipases A(2) KW - Structure-function relationships SP - 48 EP - 54 JF - Toxicon : official journal of the International Society on Toxinology JO - Toxicon VL - 184 N2 - Many venomous species, including snakes, bees and scorpions, contain a variety of secreted phospholipases A2 (sPLA2) that contribute to prey digestion and venom toxicity. Based on their primary structures, the different venom sPLA2 have been classified into four groups I, II, III and IX. While the structure of sPLA2 groups II and I has been well characterized, only one crystal structure of group III sPLA2 from bee venom was described. Scorpion venom sPLA2 belong to group III with a particular heterodimeric structure composed of a long enzymatic chain linked by a disulfide bridge to a Short one after the release of five residues (penta-peptide) during the maturation processes. The function of the Short chain is still not clear. Its sequence varies in composition and in length between different scorpion species. Available studies of the structure-function relationships of scorpion venom sPLA2 are limited. Some biological activities of these enzymes such as neurotoxicity, myotoxicity, along with the hemolytic, anticoagulant, anti-tumoral and anti-angiogenic activities have been investigated. In this review, we tentatively summarize the last findings about the biochemical properties, the structure-function relation and the biological activities of scorpion venom phospholipases A2. In addition to expanding the database of structures for these sPLA2 and understanding their properties and functions, this survey is intended to explore the molecular mechanisms and signaling pathways of the described biological activities. SN - 1879-3150 UR - https://www.unboundmedicine.com/medline/citation/32473923/Scorpion_venom_phospholipases_A2:_A_minireview L2 - https://linkinghub.elsevier.com/retrieve/pii/S0041-0101(20)30249-X DB - PRIME DP - Unbound Medicine ER -
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