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Periodontal disease and Helicobacter pylori infection in oral cavity: a meta-analysis of 2727 participants mainly based on Asian studies.
Clin Oral Investig. 2020 Jul; 24(7):2175-2188.CO

Abstract

OBJECTIVES

To assess the association between periodontal disease and Helicobacter pylori (H. pylori) infection in oral cavity.

MATERIALS AND METHODS

We searched PubMed, Embase, Web of Science, Cochrane library, Gray literature, and clinicaltrials.gov for eligible studies up to September 25, 2019. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated. The random-effects model was used with the software STATA 13.0. The Newcastle-Ottawa-Scale was used for quality evaluation.

RESULTS

Twelve observational studies (eight from Asia, one from Europe, and three from the South America) involving 2727 participants were included in the meta-analysis. The overall pooled results showed that H. pylori infection in oral cavity was associated with periodontal disease (OR 2.53, 95% CI 1.86-3.44, P < 0.05). No significant heterogeneity among the articles was observed (I2 = 44.3%, P < 0.05). The sensitivity analysis indicated that the result of our meta-analysis was generally stable. The Begg test and the Egger test both showed no publication bias was observed (P = 0.45 and P = 0.18 respectively).

CONCLUSIONS

Based on current available evidence, it seemed there was a correlation between oral H. pylori infection and the occurrence of periodontal disease. However, since most of the data comes from Asia, more large-scale investigations with high quality from all over the world are needed to confirm the association.

CLINICAL RELEVANCE

H. pylori infection in oral may have a positive association with the prevalence of periodontal disease mainly in Asian populations.

Authors+Show Affiliations

Department of Periodontics, School and Hospital of Stomatology, China Medical University, Liaoning Provincial Key Laboratory of Oral Diseases, Heping District, Nanjing North Street No.117, Shenyang, 110002, China.Department of Periodontics, School and Hospital of Stomatology, China Medical University, Liaoning Provincial Key Laboratory of Oral Diseases, Heping District, Nanjing North Street No.117, Shenyang, 110002, China.Department of Oromaxillofacial-Head and Neck Surgery, School and Hospital of Stomatology, China Medical University, Liaoning Provincial Key Laboratory of Oral Diseases, Heping District, Nanjing North Street No.117, Shenyang, 110002, China. Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, China Medical University, Liaoning Provincial Key Laboratory of Oral Diseases, Heping Distrct, Nanjing North Street No.117, Shenyang, 110002, China.Department of Periodontics, School and Hospital of Stomatology, China Medical University, Liaoning Provincial Key Laboratory of Oral Diseases, Heping District, Nanjing North Street No.117, Shenyang, 110002, China.Department of Periodontics, School and Hospital of Stomatology, China Medical University, Liaoning Provincial Key Laboratory of Oral Diseases, Heping District, Nanjing North Street No.117, Shenyang, 110002, China.Department of Periodontics, School and Hospital of Stomatology, China Medical University, Liaoning Provincial Key Laboratory of Oral Diseases, Heping District, Nanjing North Street No.117, Shenyang, 110002, China.Department of Periodontics and Oral Biology, School and Hospital of Stomatology, China Medical University, Liaoning Provincial Key Laboratory of Oral Diseases, Heping Distrct, Nanjing North Street No.117, Shenyang, 110002, China.Department of Periodontics and Oral Biology, School and Hospital of Stomatology, China Medical University, Liaoning Provincial Key Laboratory of Oral Diseases, Heping Distrct, Nanjing North Street No.117, Shenyang, 110002, China.Department of Periodontics and Oral Biology, School and Hospital of Stomatology, China Medical University, Liaoning Provincial Key Laboratory of Oral Diseases, Heping Distrct, Nanjing North Street No.117, Shenyang, 110002, China.Department of Periodontics and Oral Biology, School and Hospital of Stomatology, China Medical University, Liaoning Provincial Key Laboratory of Oral Diseases, Heping Distrct, Nanjing North Street No.117, Shenyang, 110002, China. zhangdongmei@cmu.edu.cn.

Pub Type(s)

Journal Article
Meta-Analysis

Language

eng

PubMed ID

32474810

Citation

Liu, Yanqing, et al. "Periodontal Disease and Helicobacter Pylori Infection in Oral Cavity: a Meta-analysis of 2727 Participants Mainly Based On Asian Studies." Clinical Oral Investigations, vol. 24, no. 7, 2020, pp. 2175-2188.
Liu Y, Li R, Xue X, et al. Periodontal disease and Helicobacter pylori infection in oral cavity: a meta-analysis of 2727 participants mainly based on Asian studies. Clin Oral Investig. 2020;24(7):2175-2188.
Liu, Y., Li, R., Xue, X., Xu, T., Luo, Y., Dong, Q., Liu, J., Liu, J., Pan, Y., & Zhang, D. (2020). Periodontal disease and Helicobacter pylori infection in oral cavity: a meta-analysis of 2727 participants mainly based on Asian studies. Clinical Oral Investigations, 24(7), 2175-2188. https://doi.org/10.1007/s00784-020-03330-4
Liu Y, et al. Periodontal Disease and Helicobacter Pylori Infection in Oral Cavity: a Meta-analysis of 2727 Participants Mainly Based On Asian Studies. Clin Oral Investig. 2020;24(7):2175-2188. PubMed PMID: 32474810.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Periodontal disease and Helicobacter pylori infection in oral cavity: a meta-analysis of 2727 participants mainly based on Asian studies. AU - Liu,Yanqing, AU - Li,Rong, AU - Xue,Xiaomeng, AU - Xu,Tong, AU - Luo,Yuxiao, AU - Dong,Qin, AU - Liu,Junchao, AU - Liu,Jingbo, AU - Pan,Yaping, AU - Zhang,Dongmei, Y1 - 2020/05/30/ PY - 2019/10/09/received PY - 2020/05/07/accepted PY - 2020/6/1/pubmed PY - 2020/11/3/medline PY - 2020/6/1/entrez KW - Helicobacter pylori KW - Meta-analysis KW - Oral cavity KW - Periodontal disease SP - 2175 EP - 2188 JF - Clinical oral investigations JO - Clin Oral Investig VL - 24 IS - 7 N2 - OBJECTIVES: To assess the association between periodontal disease and Helicobacter pylori (H. pylori) infection in oral cavity. MATERIALS AND METHODS: We searched PubMed, Embase, Web of Science, Cochrane library, Gray literature, and clinicaltrials.gov for eligible studies up to September 25, 2019. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated. The random-effects model was used with the software STATA 13.0. The Newcastle-Ottawa-Scale was used for quality evaluation. RESULTS: Twelve observational studies (eight from Asia, one from Europe, and three from the South America) involving 2727 participants were included in the meta-analysis. The overall pooled results showed that H. pylori infection in oral cavity was associated with periodontal disease (OR 2.53, 95% CI 1.86-3.44, P < 0.05). No significant heterogeneity among the articles was observed (I2 = 44.3%, P < 0.05). The sensitivity analysis indicated that the result of our meta-analysis was generally stable. The Begg test and the Egger test both showed no publication bias was observed (P = 0.45 and P = 0.18 respectively). CONCLUSIONS: Based on current available evidence, it seemed there was a correlation between oral H. pylori infection and the occurrence of periodontal disease. However, since most of the data comes from Asia, more large-scale investigations with high quality from all over the world are needed to confirm the association. CLINICAL RELEVANCE: H. pylori infection in oral may have a positive association with the prevalence of periodontal disease mainly in Asian populations. SN - 1436-3771 UR - https://www.unboundmedicine.com/medline/citation/32474810/Periodontal_disease_and_Helicobacter_pylori_infection_in_oral_cavity:_a_meta_analysis_of_2727_participants_mainly_based_on_Asian_studies_ L2 - https://dx.doi.org/10.1007/s00784-020-03330-4 DB - PRIME DP - Unbound Medicine ER -