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Effects of abomasal infusion of essential fatty acids together with conjugated linoleic acid in late and early lactation on performance, milk and body composition, and plasma metabolites in dairy cows.
J Dairy Sci. 2020 Aug; 103(8):7431-7450.JD

Abstract

Rations including high amounts of corn silage are currently very common in dairy production. Diets with corn silage as forage source result in a low supply of essential fatty acids, such as α-linolenic acid, and may lead to low conjugated linoleic acid (CLA) production. The present study investigated the effects of abomasal infusion of essential fatty acids, especially α-linolenic acid, and CLA in dairy cows fed a corn silage-based diet on performance, milk composition, including fatty acid (FA) pattern, and lipid metabolism from late to early lactation. Rumen-cannulated Holstein cows (n = 40) were studied from wk 9 antepartum to wk 9 postpartum and dried off 6 wk before calving. The cows were assigned to 1 of 4 treatment groups. Cows were abomasally supplemented with coconut oil (CTRL, 76 g/d), linseed and safflower oil (EFA, 78 and 4 g/d; linseed/safflower oil ratio = 19.5:1; n-6/n-3 FA ratio = 1:3), Lutalin (CLA, 38 g/d; BASF SE, Ludwigshafen, Germany; isomers cis-9,trans-11 and trans-10,cis-12 each 10 g/d) or EFA+CLA. Milk composition was analyzed weekly, and blood samples were taken several times before and after parturition to determine plasma concentrations of metabolites related to lipid metabolism. Liver samples were obtained by biopsy on d 63 and 21 antepartum and on d 1, 28, and 63 postpartum to measure triglyceride concentration. Body composition was determined after slaughter. Supplementation of CLA reduced milk fat concentration, increased body fat mass, and improved energy balance (EB) in late and early lactation, but EB was lowest during late lactation in the EFA group. Cows with CLA treatment alone showed an elevated milk citrate concentration in early lactation, whereas EFA+CLA did not reveal higher milk citrate but did have increased acetone. Milk protein was increased in late lactation but was decreased in wk 1 postpartum in CLA and EFA+CLA. Milk urea was reduced by CLA treatment during the whole period. After calving, the increase of nonesterified fatty acids in plasma was less in CLA groups; liver triglycerides were raised lowest at d 28 in CLA groups. Our data confirm an improved metabolic status with CLA but not with exclusive EFA supplementation during early lactation. Increased milk citrate concentration in CLA cows points to reduced de novo FA synthesis in the mammary gland, but milk citrate was less affected in EFA+CLA cows, indicating that EFA supplementation may influence changes in mammary gland FA metabolism achieved by CLA.

Authors+Show Affiliations

Institute of Nutritional Physiology "Oskar Kellner," Leibniz Institute for Farm Animal Biology (FBN), 18196 Dummerstorf, Germany.Institute of Nutritional Physiology "Oskar Kellner," Leibniz Institute for Farm Animal Biology (FBN), 18196 Dummerstorf, Germany.Institute of Nutritional Physiology "Oskar Kellner," Leibniz Institute for Farm Animal Biology (FBN), 18196 Dummerstorf, Germany.Institute of Muscle Biology and Growth, Leibniz Institute for Farm Animal Biology (FBN), 18196 Dummerstorf, Germany.Institute of Genetics and Biometry, Leibniz Institute for Farm Animal Biology (FBN), 18196 Dummerstorf, Germany.BASF SE, 68619 Lampertheim, Germany.Bavarian Center for Biomolecular Mass Spectrometry, Technical University of Munich, 85354 Freising, Germany.Chair of Analytical Food Chemistry, Technical University of Munich, 85354 Freising, Germany.Clinic for Ruminants and Swine, Faculty of Veterinary Medicine, University of Leipzig, 04103 Leipzig, Germany.Institute of Nutritional Physiology "Oskar Kellner," Leibniz Institute for Farm Animal Biology (FBN), 18196 Dummerstorf, Germany.Institute of Nutritional Physiology "Oskar Kellner," Leibniz Institute for Farm Animal Biology (FBN), 18196 Dummerstorf, Germany. Electronic address: hammon@fbn-dummerstorf.de.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32475659

Citation

Vogel, L, et al. "Effects of Abomasal Infusion of Essential Fatty Acids Together With Conjugated Linoleic Acid in Late and Early Lactation On Performance, Milk and Body Composition, and Plasma Metabolites in Dairy Cows." Journal of Dairy Science, vol. 103, no. 8, 2020, pp. 7431-7450.
Vogel L, Gnott M, Kröger-Koch C, et al. Effects of abomasal infusion of essential fatty acids together with conjugated linoleic acid in late and early lactation on performance, milk and body composition, and plasma metabolites in dairy cows. J Dairy Sci. 2020;103(8):7431-7450.
Vogel, L., Gnott, M., Kröger-Koch, C., Dannenberger, D., Tuchscherer, A., Tröscher, A., Kienberger, H., Rychlik, M., Starke, A., Bachmann, L., & Hammon, H. M. (2020). Effects of abomasal infusion of essential fatty acids together with conjugated linoleic acid in late and early lactation on performance, milk and body composition, and plasma metabolites in dairy cows. Journal of Dairy Science, 103(8), 7431-7450. https://doi.org/10.3168/jds.2019-18065
Vogel L, et al. Effects of Abomasal Infusion of Essential Fatty Acids Together With Conjugated Linoleic Acid in Late and Early Lactation On Performance, Milk and Body Composition, and Plasma Metabolites in Dairy Cows. J Dairy Sci. 2020;103(8):7431-7450. PubMed PMID: 32475659.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of abomasal infusion of essential fatty acids together with conjugated linoleic acid in late and early lactation on performance, milk and body composition, and plasma metabolites in dairy cows. AU - Vogel,L, AU - Gnott,M, AU - Kröger-Koch,C, AU - Dannenberger,D, AU - Tuchscherer,A, AU - Tröscher,A, AU - Kienberger,H, AU - Rychlik,M, AU - Starke,A, AU - Bachmann,L, AU - Hammon,H M, Y1 - 2020/05/29/ PY - 2019/12/16/received PY - 2020/03/24/accepted PY - 2020/6/2/pubmed PY - 2020/11/26/medline PY - 2020/6/2/entrez KW - conjugated linoleic acid KW - dairy cow KW - energy balance KW - milk components KW - α-linolenic acid SP - 7431 EP - 7450 JF - Journal of dairy science JO - J Dairy Sci VL - 103 IS - 8 N2 - Rations including high amounts of corn silage are currently very common in dairy production. Diets with corn silage as forage source result in a low supply of essential fatty acids, such as α-linolenic acid, and may lead to low conjugated linoleic acid (CLA) production. The present study investigated the effects of abomasal infusion of essential fatty acids, especially α-linolenic acid, and CLA in dairy cows fed a corn silage-based diet on performance, milk composition, including fatty acid (FA) pattern, and lipid metabolism from late to early lactation. Rumen-cannulated Holstein cows (n = 40) were studied from wk 9 antepartum to wk 9 postpartum and dried off 6 wk before calving. The cows were assigned to 1 of 4 treatment groups. Cows were abomasally supplemented with coconut oil (CTRL, 76 g/d), linseed and safflower oil (EFA, 78 and 4 g/d; linseed/safflower oil ratio = 19.5:1; n-6/n-3 FA ratio = 1:3), Lutalin (CLA, 38 g/d; BASF SE, Ludwigshafen, Germany; isomers cis-9,trans-11 and trans-10,cis-12 each 10 g/d) or EFA+CLA. Milk composition was analyzed weekly, and blood samples were taken several times before and after parturition to determine plasma concentrations of metabolites related to lipid metabolism. Liver samples were obtained by biopsy on d 63 and 21 antepartum and on d 1, 28, and 63 postpartum to measure triglyceride concentration. Body composition was determined after slaughter. Supplementation of CLA reduced milk fat concentration, increased body fat mass, and improved energy balance (EB) in late and early lactation, but EB was lowest during late lactation in the EFA group. Cows with CLA treatment alone showed an elevated milk citrate concentration in early lactation, whereas EFA+CLA did not reveal higher milk citrate but did have increased acetone. Milk protein was increased in late lactation but was decreased in wk 1 postpartum in CLA and EFA+CLA. Milk urea was reduced by CLA treatment during the whole period. After calving, the increase of nonesterified fatty acids in plasma was less in CLA groups; liver triglycerides were raised lowest at d 28 in CLA groups. Our data confirm an improved metabolic status with CLA but not with exclusive EFA supplementation during early lactation. Increased milk citrate concentration in CLA cows points to reduced de novo FA synthesis in the mammary gland, but milk citrate was less affected in EFA+CLA cows, indicating that EFA supplementation may influence changes in mammary gland FA metabolism achieved by CLA. SN - 1525-3198 UR - https://www.unboundmedicine.com/medline/citation/32475659/Effects_of_abomasal_infusion_of_essential_fatty_acids_together_with_conjugated_linoleic_acid_in_late_and_early_lactation_on_performance_milk_and_body_composition_and_plasma_metabolites_in_dairy_cows_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-0302(20)30411-2 DB - PRIME DP - Unbound Medicine ER -