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IL-6: Relevance for immunopathology of SARS-CoV-2.
Cytokine Growth Factor Rev. 2020 06; 53:13-24.CG

Abstract

COVID-19 mortality is strongly associated with the development of severe pneumonia and acute respiratory distress syndrome with the worst outcome resulting in cytokine release syndrome and multiorgan failure. It is becoming critically important to identify at the early stage of the infection those patients who are prone to develop the most adverse effects. Elevated systemic interleukin-6 levels in patients with COVID-19 are considered as a relevant parameter in predicting most severe course of disease and the need for intensive care. This review discusses the mechanisms by which IL-6 may possibly contribute to disease exacerbation and the potential of therapeutic approaches based on anti-IL-6 biologics.

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Authors+Show Affiliations

Gubernatorova EO
Laboratory of Molecular Mechanisms of Immunity, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia; Faculty of Biology, Lomonosov Moscow State University, Moscow, Russia. Electronic address: ekaterina.gubernatorova412@gmail.com.
Gorshkova EA
Laboratory of Molecular Mechanisms of Immunity, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia; Faculty of Biology, Lomonosov Moscow State University, Moscow, Russia; Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.
Polinova AI
Laboratory of Molecular Mechanisms of Immunity, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia; Faculty of Biology, Lomonosov Moscow State University, Moscow, Russia.
Drutskaya MS
Laboratory of Molecular Mechanisms of Immunity, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia; Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia. Electronic address: marinadru@gmail.com.

MeSH

Antibodies, Monoclonal, HumanizedBetacoronavirusCOVID-19Coronavirus InfectionsCytokine Release SyndromeHumansInterleukin-6Lung DiseasesPandemicsPneumonia, ViralSARS-CoV-2

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

32475759

Citation

Gubernatorova, E O., et al. "IL-6: Relevance for Immunopathology of SARS-CoV-2." Cytokine & Growth Factor Reviews, vol. 53, 2020, pp. 13-24.
Gubernatorova EO, Gorshkova EA, Polinova AI, et al. IL-6: Relevance for immunopathology of SARS-CoV-2. Cytokine Growth Factor Rev. 2020;53:13-24.
Gubernatorova, E. O., Gorshkova, E. A., Polinova, A. I., & Drutskaya, M. S. (2020). IL-6: Relevance for immunopathology of SARS-CoV-2. Cytokine & Growth Factor Reviews, 53, 13-24. https://doi.org/10.1016/j.cytogfr.2020.05.009
Gubernatorova EO, et al. IL-6: Relevance for Immunopathology of SARS-CoV-2. Cytokine Growth Factor Rev. 2020;53:13-24. PubMed PMID: 32475759.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - IL-6: Relevance for immunopathology of SARS-CoV-2. AU - Gubernatorova,E O, AU - Gorshkova,E A, AU - Polinova,A I, AU - Drutskaya,M S, Y1 - 2020/05/20/ PY - 2020/05/16/received PY - 2020/05/17/accepted PY - 2020/6/2/pubmed PY - 2020/7/1/medline PY - 2020/6/2/entrez KW - Anti-cytokine therapeutics KW - Cytokine release syndrome KW - IL-6 KW - SARS-CoV-2 SP - 13 EP - 24 JF - Cytokine & growth factor reviews JO - Cytokine Growth Factor Rev VL - 53 N2 - COVID-19 mortality is strongly associated with the development of severe pneumonia and acute respiratory distress syndrome with the worst outcome resulting in cytokine release syndrome and multiorgan failure. It is becoming critically important to identify at the early stage of the infection those patients who are prone to develop the most adverse effects. Elevated systemic interleukin-6 levels in patients with COVID-19 are considered as a relevant parameter in predicting most severe course of disease and the need for intensive care. This review discusses the mechanisms by which IL-6 may possibly contribute to disease exacerbation and the potential of therapeutic approaches based on anti-IL-6 biologics. SN - 1879-0305 UR - https://www.unboundmedicine.com/medline/citation/32475759/IL_6:_Relevance_for_immunopathology_of_SARS_CoV_2_ DB - PRIME DP - Unbound Medicine ER -