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Irinotecan inducing sinus pause bradycardia in a patient with small round cell cancer.
BMJ Case Rep. 2020 May 31; 13(5)BC

Abstract

Irinotecan is a novel anticancer drug that has worked wonders in combination with other anticancer drugs. It can be used as a single chemotherapy agent in colonic cancer treatment or in combination with 5-fluorouracil. Irinotecan has been found a better salvage therapy in patients who are resistant to 5-fluorouracil. It is also used in combination with cisplatin and other drugs for cancers such as pleural mesothelioma, Ewing's sarcoma, lung cancer and others, and has helped reduce tumour burden. Irinotecan is generally associated with gastrointestinal side effects including nausea, vomiting and diarrhoea, while cardiovascular toxicity (5%) has been reported mainly as vasodilatation and possible bradycardia with no known incidence. A case was reported in 1998 by Miya et al of a 65-year-old man with bradycardia which was managed with atropine without modifications in the dosage of irinotecan or in the rate of infusion. We report a case of a patient with small round cell cancer who presented with sinus pause bradycardia after infusion with irinotecan. The patient was managed with atropine during chemotherapy.

Authors+Show Affiliations

Internal Medicine, Detroit Medical Center, Wayne State University, Detroit, Michigan, USA gr6723@wayne.edu.Internal Medicine, Detroit Medical Center, Wayne State University, Detroit, Michigan, USA.Internal Medicine, Detroit Medical Center, Wayne State University, Detroit, Michigan, USA.Internal Medicine, Detroit Medical Center, Wayne State University, Detroit, Michigan, USA.Internal Medicine, Detroit Medical Center, Wayne State University, Detroit, Michigan, USA.Independent Researcher, Detroit, MI, USA.Internal Medicine, Detroit Medical Center, Wayne State University, Detroit, Michigan, USA.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32475823

Citation

Mir, Tanveer Ahmad, et al. "Irinotecan Inducing Sinus Pause Bradycardia in a Patient With Small Round Cell Cancer." BMJ Case Reports, vol. 13, no. 5, 2020.
Mir TA, Yassin AS, Denha EJ, et al. Irinotecan inducing sinus pause bradycardia in a patient with small round cell cancer. BMJ Case Rep. 2020;13(5).
Mir, T. A., Yassin, A. S., Denha, E. J., Shaikhli, R. A., Rahim, A., Ambreen, S., & Lohia, P. (2020). Irinotecan inducing sinus pause bradycardia in a patient with small round cell cancer. BMJ Case Reports, 13(5). https://doi.org/10.1136/bcr-2019-232053
Mir TA, et al. Irinotecan Inducing Sinus Pause Bradycardia in a Patient With Small Round Cell Cancer. BMJ Case Rep. 2020 May 31;13(5) PubMed PMID: 32475823.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Irinotecan inducing sinus pause bradycardia in a patient with small round cell cancer. AU - Mir,Tanveer Ahmad, AU - Yassin,Ahmed S, AU - Denha,Eric Joseph, AU - Shaikhli,Raad Al, AU - Rahim,Ali, AU - Ambreen,Sabah, AU - Lohia,Prateek, Y1 - 2020/05/31/ PY - 2020/6/2/entrez KW - arrhythmias KW - cardiovascular medicine KW - haematology (drugs and medicines) KW - malignant disease and immunosuppression JF - BMJ case reports JO - BMJ Case Rep VL - 13 IS - 5 N2 - Irinotecan is a novel anticancer drug that has worked wonders in combination with other anticancer drugs. It can be used as a single chemotherapy agent in colonic cancer treatment or in combination with 5-fluorouracil. Irinotecan has been found a better salvage therapy in patients who are resistant to 5-fluorouracil. It is also used in combination with cisplatin and other drugs for cancers such as pleural mesothelioma, Ewing's sarcoma, lung cancer and others, and has helped reduce tumour burden. Irinotecan is generally associated with gastrointestinal side effects including nausea, vomiting and diarrhoea, while cardiovascular toxicity (5%) has been reported mainly as vasodilatation and possible bradycardia with no known incidence. A case was reported in 1998 by Miya et al of a 65-year-old man with bradycardia which was managed with atropine without modifications in the dosage of irinotecan or in the rate of infusion. We report a case of a patient with small round cell cancer who presented with sinus pause bradycardia after infusion with irinotecan. The patient was managed with atropine during chemotherapy. SN - 1757-790X UR - https://www.unboundmedicine.com/medline/citation/32475823/Irinotecan_inducing_sinus_pause_bradycardia_in_a_patient_with_small_round_cell_cancer L2 - https://casereports.bmj.com/cgi/pmidlookup?view=long&pmid=32475823 DB - PRIME DP - Unbound Medicine ER -
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