Tags

Type your tag names separated by a space and hit enter

Altered sensorimotor cortex noradrenergic function in idiopathic REM sleep behaviour disorder - A PET study.
Parkinsonism Relat Disord. 2020 06; 75:63-69.PR

Abstract

INTRODUCTION

Noradrenergic denervation is thought to aggravate motor dysfunction in Parkinson's disease (PD). In a previous PET study with the norepinephrine transporter (NART) ligand 11C-MeNER, we detected reduced NART binding in primary sensorimotor cortex (M1S1) of PD patients. Idiopathic rapid-eye-movement sleep behaviour disorder (iRBD) is a phenotype of prodromal PD. Using 11C-MeNER PET, we investigated whether iRBD patients showed similar NART binding reductions in M1S1 cortex as PD patients. Additionally, we investigated whether 11C-MeNER binding and loss of nigrostriatal dopamine storage capacity measured with 18F-DOPA PET were correlated.

METHODS

17 iRBD patients, 16 PD patients with (PDRBD+) and 14 without RBD (PDRBD-), and 25 control subjects underwent 11C-MeNER PET. iRBD patients also had 18F-DOPA PET. Volume-of-interest analyses and voxel-level statistical parametric mapping were performed.

RESULTS

Partial-volume corrected 11C-MeNER binding potential (BPND) values in M1S1 differed across the groups (P = 0.022) with the iRBD and PDRBD+ groups showing significant reductions (controls vs. iRBD P = 0.007; control vs. PDRBD+P = 0.008). Voxel-wise comparisons confirmed reductions of M1S1 11C-MeNER binding in PD and iRBD patients. Significant correlation was seen between putaminal 18F-DOPA uptake and thalamic 11C-MeNER binding in iRBD patients (r2 = 0.343, P = 0.013).

CONCLUSIONS

This study found altered noradrenergic neurotransmission in the M1S1 cortex of iRBD patients. The observed reduction of M1S1 11C-MeNER binding in iRBD may represent noradrenergic terminal degeneration or physiological down-regulation of NARTs in this prodromal phenotype of PD. The correlation between thalamic 11C-MeNER binding and putaminal 18F-DOPA binding suggests that these neurotransmitter systems degenerate in parallel in the iRBD phenotype of prodromal PD.

Authors+Show Affiliations

Aarhus University Hospital, Department of Nuclear Medicine and PET Centre, Aarhus, Denmark. Electronic address: katrineandersen@clin.au.dk.Aarhus University Hospital, Department of Nuclear Medicine and PET Centre, Aarhus, Denmark.Aarhus University Hospital, Department of Nuclear Medicine and PET Centre, Aarhus, Denmark; Department of Neurology, University Hospital Cologne, Cologne, Germany.Aarhus University Hospital, Department of Nuclear Medicine and PET Centre, Aarhus, Denmark.Aarhus University Hospital, Department of Nuclear Medicine and PET Centre, Aarhus, Denmark.Aarhus University Hospital, Department of Nuclear Medicine and PET Centre, Aarhus, Denmark.Aarhus University Hospital, Department of Nuclear Medicine and PET Centre, Aarhus, Denmark.Aarhus University Hospital, Department of Nuclear Medicine and PET Centre, Aarhus, Denmark.Aarhus University Hospital, Department of Nuclear Medicine and PET Centre, Aarhus, Denmark; Department of Neurology, Skåne University Hospital, Sweden.Aarhus University Hospital, Department of Nuclear Medicine and PET Centre, Aarhus, Denmark; Institute of Neuroscience, Newcastle University, Newcastle, UK.Aarhus University Hospital, Department of Nuclear Medicine and PET Centre, Aarhus, Denmark; Institute of Neuroscience, Newcastle University, Newcastle, UK; Division of Brain Sciences, Imperial College London, London, UK.Aarhus University Hospital, Department of Nuclear Medicine and PET Centre, Aarhus, Denmark.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

32480309

Citation

Andersen, Katrine B., et al. "Altered Sensorimotor Cortex Noradrenergic Function in Idiopathic REM Sleep Behaviour Disorder - a PET Study." Parkinsonism & Related Disorders, vol. 75, 2020, pp. 63-69.
Andersen KB, Hansen AK, Sommerauer M, et al. Altered sensorimotor cortex noradrenergic function in idiopathic REM sleep behaviour disorder - A PET study. Parkinsonism Relat Disord. 2020;75:63-69.
Andersen, K. B., Hansen, A. K., Sommerauer, M., Fedorova, T. D., Knudsen, K., Vang, K., Van Den Berge, N., Kinnerup, M., Nahimi, A., Pavese, N., Brooks, D. J., & Borghammer, P. (2020). Altered sensorimotor cortex noradrenergic function in idiopathic REM sleep behaviour disorder - A PET study. Parkinsonism & Related Disorders, 75, 63-69. https://doi.org/10.1016/j.parkreldis.2020.05.013
Andersen KB, et al. Altered Sensorimotor Cortex Noradrenergic Function in Idiopathic REM Sleep Behaviour Disorder - a PET Study. Parkinsonism Relat Disord. 2020;75:63-69. PubMed PMID: 32480309.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Altered sensorimotor cortex noradrenergic function in idiopathic REM sleep behaviour disorder - A PET study. AU - Andersen,Katrine B, AU - Hansen,Allan K, AU - Sommerauer,Michael, AU - Fedorova,Tatyana D, AU - Knudsen,Karoline, AU - Vang,Kim, AU - Van Den Berge,Nathalie, AU - Kinnerup,Martin, AU - Nahimi,Adjmal, AU - Pavese,Nicola, AU - Brooks,David J, AU - Borghammer,Per, Y1 - 2020/05/19/ PY - 2019/07/11/received PY - 2020/02/27/revised PY - 2020/05/08/accepted PY - 2020/6/2/pubmed PY - 2021/6/23/medline PY - 2020/6/2/entrez KW - (11)C-MeNER positron emission tomography (PET) KW - Idiopathic rapid-eye-movement (REM) sleep behaviour disorder (RBD) KW - Motor cortex KW - Noradrenaline KW - Parkinson's disease KW - Primary motor-sensory cortex SP - 63 EP - 69 JF - Parkinsonism & related disorders JO - Parkinsonism Relat Disord VL - 75 N2 - INTRODUCTION: Noradrenergic denervation is thought to aggravate motor dysfunction in Parkinson's disease (PD). In a previous PET study with the norepinephrine transporter (NART) ligand 11C-MeNER, we detected reduced NART binding in primary sensorimotor cortex (M1S1) of PD patients. Idiopathic rapid-eye-movement sleep behaviour disorder (iRBD) is a phenotype of prodromal PD. Using 11C-MeNER PET, we investigated whether iRBD patients showed similar NART binding reductions in M1S1 cortex as PD patients. Additionally, we investigated whether 11C-MeNER binding and loss of nigrostriatal dopamine storage capacity measured with 18F-DOPA PET were correlated. METHODS: 17 iRBD patients, 16 PD patients with (PDRBD+) and 14 without RBD (PDRBD-), and 25 control subjects underwent 11C-MeNER PET. iRBD patients also had 18F-DOPA PET. Volume-of-interest analyses and voxel-level statistical parametric mapping were performed. RESULTS: Partial-volume corrected 11C-MeNER binding potential (BPND) values in M1S1 differed across the groups (P = 0.022) with the iRBD and PDRBD+ groups showing significant reductions (controls vs. iRBD P = 0.007; control vs. PDRBD+P = 0.008). Voxel-wise comparisons confirmed reductions of M1S1 11C-MeNER binding in PD and iRBD patients. Significant correlation was seen between putaminal 18F-DOPA uptake and thalamic 11C-MeNER binding in iRBD patients (r2 = 0.343, P = 0.013). CONCLUSIONS: This study found altered noradrenergic neurotransmission in the M1S1 cortex of iRBD patients. The observed reduction of M1S1 11C-MeNER binding in iRBD may represent noradrenergic terminal degeneration or physiological down-regulation of NARTs in this prodromal phenotype of PD. The correlation between thalamic 11C-MeNER binding and putaminal 18F-DOPA binding suggests that these neurotransmitter systems degenerate in parallel in the iRBD phenotype of prodromal PD. SN - 1873-5126 UR - https://www.unboundmedicine.com/medline/citation/32480309/Altered_sensorimotor_cortex_noradrenergic_function_in_idiopathic_REM_sleep_behaviour_disorder___A_PET_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1353-8020(20)30122-X DB - PRIME DP - Unbound Medicine ER -