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Mitochondrial MicroRNAs in Aging and Neurodegenerative Diseases.
Cells. 2020 05 28; 9(6)C

Abstract

MicroRNAs (miRNAs) are important regulators of several biological processes, such as cell growth, cell proliferation, embryonic development, tissue differentiation, and apoptosis. Currently, over 2000 mammalian miRNAs have been reported to regulate these biological processes. A subset of microRNAs was found to be localized to human mitochondria (mitomiRs). Through years of research, over 400 mitomiRs have been shown to modulate the translational activity of the mitochondrial genome. While miRNAs have been studied for years, the function of mitomiRs and their role in neurodegenerative pathologies is not known. The purpose of our article is to highlight recent findings that relate mitomiRs to neurodegenerative diseases, including Alzheimer's, Parkinson's, and Huntington's. We also discuss the involvement of mitomiRs in regulating the mitochondrial genome in age-related neurodegenerative diseases.

Links

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Authors+Show Affiliations

John A
Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA.
Kubosumi A
Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA.
Reddy PH
Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA. Department of Pharmacology and Neuroscience, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA. Department of Neurology, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA. Department of Public Health, Graduate School of Biomedical Sciences, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA. Department of Speech, Language, and Hearing Sciences, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA.

MeSH

AgingAnimalsHumansMicroRNAsMitochondriaModels, BiologicalNeurodegenerative DiseasesOxidative Stress

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Review

Language

eng

PubMed ID

32481587

Citation

John, Albin, et al. "Mitochondrial MicroRNAs in Aging and Neurodegenerative Diseases." Cells, vol. 9, no. 6, 2020.
John A, Kubosumi A, Reddy PH. Mitochondrial MicroRNAs in Aging and Neurodegenerative Diseases. Cells. 2020;9(6).
John, A., Kubosumi, A., & Reddy, P. H. (2020). Mitochondrial MicroRNAs in Aging and Neurodegenerative Diseases. Cells, 9(6). https://doi.org/10.3390/cells9061345
John A, Kubosumi A, Reddy PH. Mitochondrial MicroRNAs in Aging and Neurodegenerative Diseases. Cells. 2020 05 28;9(6) PubMed PMID: 32481587.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mitochondrial MicroRNAs in Aging and Neurodegenerative Diseases. AU - John,Albin, AU - Kubosumi,Aaron, AU - Reddy,P Hemachandra, Y1 - 2020/05/28/ PY - 2020/04/07/received PY - 2020/05/26/revised PY - 2020/05/27/accepted PY - 2020/6/3/entrez PY - 2020/6/3/pubmed PY - 2021/3/4/medline KW - Alzheimer’s disease KW - Huntington’s disease KW - Parkinson’s disease KW - aging KW - microRNAs KW - mitochondrial function and mitophagy KW - mitochondrial microRNAs KW - oxidative stress JF - Cells JO - Cells VL - 9 IS - 6 N2 - MicroRNAs (miRNAs) are important regulators of several biological processes, such as cell growth, cell proliferation, embryonic development, tissue differentiation, and apoptosis. Currently, over 2000 mammalian miRNAs have been reported to regulate these biological processes. A subset of microRNAs was found to be localized to human mitochondria (mitomiRs). Through years of research, over 400 mitomiRs have been shown to modulate the translational activity of the mitochondrial genome. While miRNAs have been studied for years, the function of mitomiRs and their role in neurodegenerative pathologies is not known. The purpose of our article is to highlight recent findings that relate mitomiRs to neurodegenerative diseases, including Alzheimer's, Parkinson's, and Huntington's. We also discuss the involvement of mitomiRs in regulating the mitochondrial genome in age-related neurodegenerative diseases. SN - 2073-4409 UR - https://www.unboundmedicine.com/medline/citation/32481587/Mitochondrial_MicroRNAs_in_Aging_and_Neurodegenerative_Diseases_ DB - PRIME DP - Unbound Medicine ER -