Tags

Type your tag names separated by a space and hit enter

SARS-CoV-2 infection and overactivation of Nlrp3 inflammasome as a trigger of cytokine "storm" and risk factor for damage of hematopoietic stem cells.
Leukemia. 2020 Jul; 34(7):1726-1729.L

Abstract

The scientific community faces an unexpected and urgent challenge related to the SARS-CoV-2 pandemic and is investigating the role of receptors involved in entry of this virus into cells as well as pathomechanisms leading to a cytokine "storm," which in many cases ends in severe acute respiratory syndrome, fulminant myocarditis and kidney injury. An important question is if it may also damage hematopoietic stem progenitor cells?

Links

PMC Free PDF

Authors+Show Affiliations

Ratajczak MZ
Stem Cell Institute at James Graham Brown Cancer Center, University of Louisville, Kentucky, USA. mzrata01@louisville.edu. Department of Regenerative Medicine, Center for Preclinical Research and Technology, Medical University of Warsaw, Warsaw, Poland. mzrata01@louisville.edu.
Kucia M
Stem Cell Institute at James Graham Brown Cancer Center, University of Louisville, Kentucky, USA. Department of Regenerative Medicine, Center for Preclinical Research and Technology, Medical University of Warsaw, Warsaw, Poland.

MeSH

Acute Kidney InjuryAngiotensin-Converting Enzyme 2BetacoronavirusCOVID-19Coronavirus InfectionsCytokine Release SyndromeCytokinesFuransGene Expression RegulationHematopoietic Stem CellsHeterocyclic Compounds, 4 or More RingsHumansImmunity, InnateImmunologic FactorsIndenesInflammasomesMyocarditisNLR Family, Pyrin Domain-Containing 3 ProteinPandemicsPeptidyl-Dipeptidase APneumonia, ViralPyroptosisRisk FactorsSARS-CoV-2Severe Acute Respiratory SyndromeSpike Glycoprotein, CoronavirusSulfonamidesSulfonesT-Lymphocytes

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

32483300

Citation

Ratajczak, Mariusz Z., and Magda Kucia. "SARS-CoV-2 Infection and Overactivation of Nlrp3 Inflammasome as a Trigger of Cytokine "storm" and Risk Factor for Damage of Hematopoietic Stem Cells." Leukemia, vol. 34, no. 7, 2020, pp. 1726-1729.
Ratajczak MZ, Kucia M. SARS-CoV-2 infection and overactivation of Nlrp3 inflammasome as a trigger of cytokine "storm" and risk factor for damage of hematopoietic stem cells. Leukemia. 2020;34(7):1726-1729.
Ratajczak, M. Z., & Kucia, M. (2020). SARS-CoV-2 infection and overactivation of Nlrp3 inflammasome as a trigger of cytokine "storm" and risk factor for damage of hematopoietic stem cells. Leukemia, 34(7), 1726-1729. https://doi.org/10.1038/s41375-020-0887-9
Ratajczak MZ, Kucia M. SARS-CoV-2 Infection and Overactivation of Nlrp3 Inflammasome as a Trigger of Cytokine "storm" and Risk Factor for Damage of Hematopoietic Stem Cells. Leukemia. 2020;34(7):1726-1729. PubMed PMID: 32483300.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - SARS-CoV-2 infection and overactivation of Nlrp3 inflammasome as a trigger of cytokine "storm" and risk factor for damage of hematopoietic stem cells. AU - Ratajczak,Mariusz Z, AU - Kucia,Magda, Y1 - 2020/06/01/ PY - 2020/5/5/received PY - 2020/5/21/accepted PY - 2020/5/18/revised PY - 2020/6/3/pubmed PY - 2020/7/15/medline PY - 2020/6/3/entrez SP - 1726 EP - 1729 JF - Leukemia JO - Leukemia VL - 34 IS - 7 N2 - The scientific community faces an unexpected and urgent challenge related to the SARS-CoV-2 pandemic and is investigating the role of receptors involved in entry of this virus into cells as well as pathomechanisms leading to a cytokine "storm," which in many cases ends in severe acute respiratory syndrome, fulminant myocarditis and kidney injury. An important question is if it may also damage hematopoietic stem progenitor cells? SN - 1476-5551 UR - https://www.unboundmedicine.com/medline/citation/32483300/SARS_CoV_2_infection_and_overactivation_of_Nlrp3_inflammasome_as_a_trigger_of_cytokine_"storm"_and_risk_factor_for_damage_of_hematopoietic_stem_cells_ DB - PRIME DP - Unbound Medicine ER -