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Alcohol, Alcoholic Beverages and Risk of Esophageal Cancer by Histological Type: A Dose-Response Meta-Analysis of Observational Studies.
Alcohol Alcohol. 2020 Aug 14; 55(5):457-467.AA

Abstract

AIMS

We conducted a dose-response meta-analysis to explore the association between alcohol and particular alcoholic beverages with risk of esophageal cancer (EC) by histological type [esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC)] and whether the association differs according to gender.

METHODS

PubMed and Web of Science databases were searched for relevant articles published between January 1960 and December 2019. The pooled relative ratios (RRs) and 95% confidence interval (CI) were calculated with the fixed or random effect model. The dose-response relationship was assessed by restricted cubic spline.

RESULTS

A total of 74 published articles involving 31,105 cases among 3,369,024 participants were included in this meta-analysis. The pooled RRs of the highest versus lowest alcohol intake were 3.67 (95% CI, 2.89,4.67) for EC, 5.11 (95% CI, 3.60,7.25) for ESCC and 0.96 (95% CI, 0.79,1.16) for EAC. The above-mentioned associations were observed in cohort design, for different alcoholic beverages (beer, wine and liquor/spirits) and gender. Evidence of a nonlinear dose-response relationship for EC risk with alcohol intake was found (Pnon-linearity < 0.001), and a linear relationship (Pnon-linearity = 0.216) suggested that the risk of ESCC increased by 33% for every 12.5 g/day increment of alcohol intake.

CONCLUSIONS

This meta-analysis suggests that alcohol intake might significantly increase the incidence of EC, especially for ESCC.

Authors+Show Affiliations

Department of Epidemiology and Health Statistics, The School of Public Health of Qingdao University, 308 Ningxia Road, Qingdao, Shandong 266071, People's Republic of China.Department of Epidemiology and Health Statistics, The School of Public Health of Qingdao University, 308 Ningxia Road, Qingdao, Shandong 266071, People's Republic of China.Department of Epidemiology and Health Statistics, The School of Public Health of Qingdao University, 308 Ningxia Road, Qingdao, Shandong 266071, People's Republic of China.Department of Epidemiology and Health Statistics, The School of Public Health of Qingdao University, 308 Ningxia Road, Qingdao, Shandong 266071, People's Republic of China.

Pub Type(s)

Journal Article
Meta-Analysis

Language

eng

PubMed ID

32484205

Citation

Yu, Xiaohui, et al. "Alcohol, Alcoholic Beverages and Risk of Esophageal Cancer By Histological Type: a Dose-Response Meta-Analysis of Observational Studies." Alcohol and Alcoholism (Oxford, Oxfordshire), vol. 55, no. 5, 2020, pp. 457-467.
Yu X, Chen J, Jiang W, et al. Alcohol, Alcoholic Beverages and Risk of Esophageal Cancer by Histological Type: A Dose-Response Meta-Analysis of Observational Studies. Alcohol Alcohol. 2020;55(5):457-467.
Yu, X., Chen, J., Jiang, W., & Zhang, D. (2020). Alcohol, Alcoholic Beverages and Risk of Esophageal Cancer by Histological Type: A Dose-Response Meta-Analysis of Observational Studies. Alcohol and Alcoholism (Oxford, Oxfordshire), 55(5), 457-467. https://doi.org/10.1093/alcalc/agaa047
Yu X, et al. Alcohol, Alcoholic Beverages and Risk of Esophageal Cancer By Histological Type: a Dose-Response Meta-Analysis of Observational Studies. Alcohol Alcohol. 2020 Aug 14;55(5):457-467. PubMed PMID: 32484205.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alcohol, Alcoholic Beverages and Risk of Esophageal Cancer by Histological Type: A Dose-Response Meta-Analysis of Observational Studies. AU - Yu,Xiaohui, AU - Chen,Jiahao, AU - Jiang,Wenjie, AU - Zhang,Dongfeng, PY - 2020/03/18/received PY - 2020/04/14/revised PY - 2020/04/29/accepted PY - 2020/6/3/pubmed PY - 2021/6/11/medline PY - 2020/6/3/entrez SP - 457 EP - 467 JF - Alcohol and alcoholism (Oxford, Oxfordshire) JO - Alcohol Alcohol VL - 55 IS - 5 N2 - AIMS: We conducted a dose-response meta-analysis to explore the association between alcohol and particular alcoholic beverages with risk of esophageal cancer (EC) by histological type [esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC)] and whether the association differs according to gender. METHODS: PubMed and Web of Science databases were searched for relevant articles published between January 1960 and December 2019. The pooled relative ratios (RRs) and 95% confidence interval (CI) were calculated with the fixed or random effect model. The dose-response relationship was assessed by restricted cubic spline. RESULTS: A total of 74 published articles involving 31,105 cases among 3,369,024 participants were included in this meta-analysis. The pooled RRs of the highest versus lowest alcohol intake were 3.67 (95% CI, 2.89,4.67) for EC, 5.11 (95% CI, 3.60,7.25) for ESCC and 0.96 (95% CI, 0.79,1.16) for EAC. The above-mentioned associations were observed in cohort design, for different alcoholic beverages (beer, wine and liquor/spirits) and gender. Evidence of a nonlinear dose-response relationship for EC risk with alcohol intake was found (Pnon-linearity < 0.001), and a linear relationship (Pnon-linearity = 0.216) suggested that the risk of ESCC increased by 33% for every 12.5 g/day increment of alcohol intake. CONCLUSIONS: This meta-analysis suggests that alcohol intake might significantly increase the incidence of EC, especially for ESCC. SN - 1464-3502 UR - https://www.unboundmedicine.com/medline/citation/32484205/Alcohol_Alcoholic_Beverages_and_Risk_of_Esophageal_Cancer_by_Histological_Type:_A_Dose_Response_Meta_Analysis_of_Observational_Studies_ L2 - https://academic.oup.com/alcalc/article-lookup/doi/10.1093/alcalc/agaa047 DB - PRIME DP - Unbound Medicine ER -