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Safety assessment of a new nanoemulsion-based drug-delivery system reveals unexpected drug-free anticoagulant activity.
Nanomedicine (Lond). 2020 Jun; 15(14):1361-1373.N

Abstract

Aim:

A preclinical safety assessment of a novel nanoemulsion drug-delivery system, initially developed to improve the posology of efavirenz (EFV), was conducted with a specific focus on possible immunological and hematological complications. Materials & methods: Assessment of common acute toxicities, such as complement activation and cytokine secretion, was performed using validated assays known to have good correlation with in vivo end points. Results & conclusion: Compared with a standard aqueous solution of EFV, the EFV nanoemulsion showed no significant effect on immune cell function or phenotype. Prolongation of activated partial thromboplastin time was observed for EFV-loaded nanoemulsions (88% at 4 μg/ml) as well as unloaded nanoemulsions (52%) highlighting the potential for drug-free anticoagulant activity and warranting further investigation of the mechanism and utility of these materials.

Authors+Show Affiliations

Department of Chemistry, University of Liverpool, Liverpool, L69 7ZD, UK.Department of Chemistry, University of Liverpool, Liverpool, L69 7ZD, UK.Department of Molecular & Clinical Pharmacology, University of Liverpool, Liverpool, L69 3GF, UK. European Nanomedicine Characterisation Laboratory, University of Liverpool, Liverpool, L7 3NY, UK.Department of Molecular & Clinical Pharmacology, University of Liverpool, Liverpool, L69 3GF, UK. European Nanomedicine Characterisation Laboratory, University of Liverpool, Liverpool, L7 3NY, UK.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32484393

Citation

Hobson, James J., et al. "Safety Assessment of a New Nanoemulsion-based Drug-delivery System Reveals Unexpected Drug-free Anticoagulant Activity." Nanomedicine (London, England), vol. 15, no. 14, 2020, pp. 1361-1373.
Hobson JJ, Rannard SP, Owen A, et al. Safety assessment of a new nanoemulsion-based drug-delivery system reveals unexpected drug-free anticoagulant activity. Nanomedicine (Lond). 2020;15(14):1361-1373.
Hobson, J. J., Rannard, S. P., Owen, A., & Liptrott, N. J. (2020). Safety assessment of a new nanoemulsion-based drug-delivery system reveals unexpected drug-free anticoagulant activity. Nanomedicine (London, England), 15(14), 1361-1373. https://doi.org/10.2217/nnm-2019-0447
Hobson JJ, et al. Safety Assessment of a New Nanoemulsion-based Drug-delivery System Reveals Unexpected Drug-free Anticoagulant Activity. Nanomedicine (Lond). 2020;15(14):1361-1373. PubMed PMID: 32484393.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Safety assessment of a new nanoemulsion-based drug-delivery system reveals unexpected drug-free anticoagulant activity. AU - Hobson,James J, AU - Rannard,Steve P, AU - Owen,Andrew, AU - Liptrott,Neill J, Y1 - 2020/06/02/ PY - 2020/6/3/pubmed PY - 2020/6/3/medline PY - 2020/6/3/entrez KW - HIV KW - immunotoxicity KW - nanoemulsion KW - nanomedicine KW - preclinical KW - safety SP - 1361 EP - 1373 JF - Nanomedicine (London, England) JO - Nanomedicine (Lond) VL - 15 IS - 14 N2 - Aim: A preclinical safety assessment of a novel nanoemulsion drug-delivery system, initially developed to improve the posology of efavirenz (EFV), was conducted with a specific focus on possible immunological and hematological complications. Materials & methods: Assessment of common acute toxicities, such as complement activation and cytokine secretion, was performed using validated assays known to have good correlation with in vivo end points. Results & conclusion: Compared with a standard aqueous solution of EFV, the EFV nanoemulsion showed no significant effect on immune cell function or phenotype. Prolongation of activated partial thromboplastin time was observed for EFV-loaded nanoemulsions (88% at 4 μg/ml) as well as unloaded nanoemulsions (52%) highlighting the potential for drug-free anticoagulant activity and warranting further investigation of the mechanism and utility of these materials. SN - 1748-6963 UR - https://www.unboundmedicine.com/medline/citation/32484393/Safety_assessment_of_a_new_nanoemulsion-based_drug-delivery_system_reveals_unexpected,_drug-free,_anticoagulant_activity L2 - https://www.futuremedicine.com/doi/10.2217/nnm-2019-0447?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -
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