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Syphilitic Pulmonary Inflammatory Pseudotumor: A Diagnostic Challenge.
Int J Surg Pathol. 2021 Feb; 29(1):90-96.IJ

Abstract

A 46-year-old man presented with nonproductive cough and lower limb swelling. Chest radiograph showed a left lower lobe lung mass and multiple subpleural nodules. Other investigations revealed that he had nephrotic syndrome. Core biopsies of the left lower lobe lung mass showed features of inflammatory pseudotumor with endarteritis obliterans and a lymphoplasmacytic infiltrate. Immunohistochemical stain for Treponema pallidum was positive. Resolution of the lung mass and nephrotic syndrome was achieved after treatment with intramuscular benzathine benzylpenicillin. The differential diagnosis of pulmonary inflammatory pseudotumor, manifestations of pulmonary syphilis, and a literature review of secondary syphilis of the lung are discussed.

Authors+Show Affiliations

University of Cape Town, Cape Town, South Africa. PathCare, Claremont, Cape Town, South Africa.University of Cape Town, Cape Town, South Africa. NHLS-Groote Schuur Hospital, Cape Town, South Africa.University of Cape Town, Cape Town, South Africa. NHLS-Groote Schuur Hospital, Cape Town, South Africa.

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

32486870

Citation

Govender, Dhirendra, et al. "Syphilitic Pulmonary Inflammatory Pseudotumor: a Diagnostic Challenge." International Journal of Surgical Pathology, vol. 29, no. 1, 2021, pp. 90-96.
Govender D, Jackson C, Chetty D. Syphilitic Pulmonary Inflammatory Pseudotumor: A Diagnostic Challenge. Int J Surg Pathol. 2021;29(1):90-96.
Govender, D., Jackson, C., & Chetty, D. (2021). Syphilitic Pulmonary Inflammatory Pseudotumor: A Diagnostic Challenge. International Journal of Surgical Pathology, 29(1), 90-96. https://doi.org/10.1177/1066896920928584
Govender D, Jackson C, Chetty D. Syphilitic Pulmonary Inflammatory Pseudotumor: a Diagnostic Challenge. Int J Surg Pathol. 2021;29(1):90-96. PubMed PMID: 32486870.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Syphilitic Pulmonary Inflammatory Pseudotumor: A Diagnostic Challenge. AU - Govender,Dhirendra, AU - Jackson,Christopher, AU - Chetty,Dharshnee, Y1 - 2020/06/02/ PY - 2020/6/4/pubmed PY - 2021/7/9/medline PY - 2020/6/4/entrez KW - infections KW - inflammatory pseudotumor KW - lung KW - pulmonary KW - syphilis SP - 90 EP - 96 JF - International journal of surgical pathology JO - Int J Surg Pathol VL - 29 IS - 1 N2 - A 46-year-old man presented with nonproductive cough and lower limb swelling. Chest radiograph showed a left lower lobe lung mass and multiple subpleural nodules. Other investigations revealed that he had nephrotic syndrome. Core biopsies of the left lower lobe lung mass showed features of inflammatory pseudotumor with endarteritis obliterans and a lymphoplasmacytic infiltrate. Immunohistochemical stain for Treponema pallidum was positive. Resolution of the lung mass and nephrotic syndrome was achieved after treatment with intramuscular benzathine benzylpenicillin. The differential diagnosis of pulmonary inflammatory pseudotumor, manifestations of pulmonary syphilis, and a literature review of secondary syphilis of the lung are discussed. SN - 1940-2465 UR - https://www.unboundmedicine.com/medline/citation/32486870/Syphilitic_Pulmonary_Inflammatory_Pseudotumor:_A_Diagnostic_Challenge_ L2 - https://journals.sagepub.com/doi/10.1177/1066896920928584?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -