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The glucose enzyme electrode: is simple peroxide detection at a needle sensor acceptable?
Horm Metab Res Suppl. 1988; 20:20-2.HM

Abstract

Needle type devices have been fabricated based on Pt anodes (to detect H2O2) mounted with stainless steel needles to act as the reference. Coating of these devices with glucose oxidase allowed glucose measurement, but with high dependence on stirring and background pO2 levels as well as a restricted glucose assay range. By wet dipcoating of microporous polyurethane or the application of preformed porous membranes, the linear range has been extended up to 70 mM glucose, to give minimal pO2 dependence and insensitivity to stirring. With incorporation of polyethersulphone membranes, blood measurement was possible with high selectivity (y = 0.954x + 0.202, r = 0.991, n = 48). This establishes that simple peroxide detection at a needle sensor is acceptable, and can now be focussed on increasing biocompatibility.

Authors+Show Affiliations

University of Newcastle, England.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

3248785

Citation

Vadgama, P, et al. "The Glucose Enzyme Electrode: Is Simple Peroxide Detection at a Needle Sensor Acceptable?" Hormone and Metabolic Research. Supplement Series, vol. 20, 1988, pp. 20-2.
Vadgama P, Mullen W, Churchouse S, et al. The glucose enzyme electrode: is simple peroxide detection at a needle sensor acceptable? Horm Metab Res Suppl. 1988;20:20-2.
Vadgama, P., Mullen, W., Churchouse, S., & Battersby, C. (1988). The glucose enzyme electrode: is simple peroxide detection at a needle sensor acceptable? Hormone and Metabolic Research. Supplement Series, 20, 20-2.
Vadgama P, et al. The Glucose Enzyme Electrode: Is Simple Peroxide Detection at a Needle Sensor Acceptable. Horm Metab Res Suppl. 1988;20:20-2. PubMed PMID: 3248785.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The glucose enzyme electrode: is simple peroxide detection at a needle sensor acceptable? AU - Vadgama,P, AU - Mullen,W, AU - Churchouse,S, AU - Battersby,C, PY - 1988/1/1/pubmed PY - 1988/1/1/medline PY - 1988/1/1/entrez SP - 20 EP - 2 JF - Hormone and metabolic research. Supplement series JO - Horm Metab Res Suppl VL - 20 N2 - Needle type devices have been fabricated based on Pt anodes (to detect H2O2) mounted with stainless steel needles to act as the reference. Coating of these devices with glucose oxidase allowed glucose measurement, but with high dependence on stirring and background pO2 levels as well as a restricted glucose assay range. By wet dipcoating of microporous polyurethane or the application of preformed porous membranes, the linear range has been extended up to 70 mM glucose, to give minimal pO2 dependence and insensitivity to stirring. With incorporation of polyethersulphone membranes, blood measurement was possible with high selectivity (y = 0.954x + 0.202, r = 0.991, n = 48). This establishes that simple peroxide detection at a needle sensor is acceptable, and can now be focussed on increasing biocompatibility. SN - 0170-5903 UR - https://www.unboundmedicine.com/medline/citation/3248785/The_glucose_enzyme_electrode:_is_simple_peroxide_detection_at_a_needle_sensor_acceptable L2 - https://medlineplus.gov/bloodsugar.html DB - PRIME DP - Unbound Medicine ER -