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The GOD-H2O2-electrode as an approach to implantable glucose sensors.
Horm Metab Res Suppl. 1988; 20:26-9.HM

Abstract

The long-term function of glucose sensors under in-vivo conditions is the first prerequisite in the development of glucose-controlled insulin infusion systems. Amperometric enzyme glucose sensors measuring H2O2 from the enzymatic glucose oxidation are defeated to certain poisoning effects of the electrochemical system and to alterations of the diffusional properties, both resulting in unpredictable changes of the sensor signal. To interpret the signal of subcutaneously implanted sensors after reaching a certain balance of the altering processes, the wick-technique has been established as an independent reference method applicable in the interstitial fluid. Based on the comparison of the wick-glucose concentration and the circulating plasma glucose concentration the in vivo-calibration of the sensor current according to plasma glucose concentration is proven.

Authors+Show Affiliations

Central Institute of Diabetes Gerhardt Katsch, German Democratic Republic.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

3248787

Citation

Abel, P, et al. "The GOD-H2O2-electrode as an Approach to Implantable Glucose Sensors." Hormone and Metabolic Research. Supplement Series, vol. 20, 1988, pp. 26-9.
Abel P, Fischer U, Brunstein E, et al. The GOD-H2O2-electrode as an approach to implantable glucose sensors. Horm Metab Res Suppl. 1988;20:26-9.
Abel, P., Fischer, U., Brunstein, E., & Ertle, R. (1988). The GOD-H2O2-electrode as an approach to implantable glucose sensors. Hormone and Metabolic Research. Supplement Series, 20, 26-9.
Abel P, et al. The GOD-H2O2-electrode as an Approach to Implantable Glucose Sensors. Horm Metab Res Suppl. 1988;20:26-9. PubMed PMID: 3248787.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The GOD-H2O2-electrode as an approach to implantable glucose sensors. AU - Abel,P, AU - Fischer,U, AU - Brunstein,E, AU - Ertle,R, PY - 1988/1/1/pubmed PY - 1988/1/1/medline PY - 1988/1/1/entrez SP - 26 EP - 9 JF - Hormone and metabolic research. Supplement series JO - Horm Metab Res Suppl VL - 20 N2 - The long-term function of glucose sensors under in-vivo conditions is the first prerequisite in the development of glucose-controlled insulin infusion systems. Amperometric enzyme glucose sensors measuring H2O2 from the enzymatic glucose oxidation are defeated to certain poisoning effects of the electrochemical system and to alterations of the diffusional properties, both resulting in unpredictable changes of the sensor signal. To interpret the signal of subcutaneously implanted sensors after reaching a certain balance of the altering processes, the wick-technique has been established as an independent reference method applicable in the interstitial fluid. Based on the comparison of the wick-glucose concentration and the circulating plasma glucose concentration the in vivo-calibration of the sensor current according to plasma glucose concentration is proven. SN - 0170-5903 UR - https://www.unboundmedicine.com/medline/citation/3248787/The_GOD_H2O2_electrode_as_an_approach_to_implantable_glucose_sensors_ L2 - https://www.lens.org/lens/search/patent/list?q=citation_id:3248787 DB - PRIME DP - Unbound Medicine ER -