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Progress towards in vivo glucose sensing with a ferrocene-mediated amperometric enzyme electrode.
Horm Metab Res Suppl. 1988; 20:34-6.HM

Abstract

A range of miniature, amperometric enzyme electrodes have been constructed using the principle of mediated transfer of electrons. Ferrocene, or one of its derivatives, can be used in conjunction with immobilised glucose oxidase to produce sensors which are linear to at least 20 mmol/l glucose, have fast response times, are relatively oxygen insensitive and are suitable for implantation studies. In preliminary experiments in non-diabetic pigs, electrode responses followed blood responses, although mean tissue levels were about one fifth of those in blood. The ferrocene technology thus appears to be suitable for adaptation to the construction of implantable glucose electrodes for use in diabetic man.

Authors+Show Affiliations

Division of Chemical Pathology, United Medical School, Guy's Hospital, London, United Kingdom.No affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

3248788

Citation

Pickup, J C., and D J. Claremont. "Progress Towards in Vivo Glucose Sensing With a Ferrocene-mediated Amperometric Enzyme Electrode." Hormone and Metabolic Research. Supplement Series, vol. 20, 1988, pp. 34-6.
Pickup JC, Claremont DJ. Progress towards in vivo glucose sensing with a ferrocene-mediated amperometric enzyme electrode. Horm Metab Res Suppl. 1988;20:34-6.
Pickup, J. C., & Claremont, D. J. (1988). Progress towards in vivo glucose sensing with a ferrocene-mediated amperometric enzyme electrode. Hormone and Metabolic Research. Supplement Series, 20, 34-6.
Pickup JC, Claremont DJ. Progress Towards in Vivo Glucose Sensing With a Ferrocene-mediated Amperometric Enzyme Electrode. Horm Metab Res Suppl. 1988;20:34-6. PubMed PMID: 3248788.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Progress towards in vivo glucose sensing with a ferrocene-mediated amperometric enzyme electrode. AU - Pickup,J C, AU - Claremont,D J, PY - 1988/1/1/pubmed PY - 1988/1/1/medline PY - 1988/1/1/entrez SP - 34 EP - 6 JF - Hormone and metabolic research. Supplement series JO - Horm Metab Res Suppl VL - 20 N2 - A range of miniature, amperometric enzyme electrodes have been constructed using the principle of mediated transfer of electrons. Ferrocene, or one of its derivatives, can be used in conjunction with immobilised glucose oxidase to produce sensors which are linear to at least 20 mmol/l glucose, have fast response times, are relatively oxygen insensitive and are suitable for implantation studies. In preliminary experiments in non-diabetic pigs, electrode responses followed blood responses, although mean tissue levels were about one fifth of those in blood. The ferrocene technology thus appears to be suitable for adaptation to the construction of implantable glucose electrodes for use in diabetic man. SN - 0170-5903 UR - https://www.unboundmedicine.com/medline/citation/3248788/Progress_towards_in_vivo_glucose_sensing_with_a_ferrocene_mediated_amperometric_enzyme_electrode_ L2 - https://medlineplus.gov/bloodsugar.html DB - PRIME DP - Unbound Medicine ER -