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    A potentially implantable enzyme electrode for amperometric measurement of glucose.

    Abstract

    A membrane limited amperometric enzyme electrode suitable for glucose measurement in biological fluids was developed. The sensor consists of a central platinum wire (0.3 mm) surrounded by a stainless steel tubing (0.8-1.0 mm outer diameter; 2-4 cm length). By successive dipcoating procedures, layers from cellulose acetate, glucose oxidase (crosslinked with glutaraldehyde) and polyurethane are placed on its surface. The platinum is polarized at +700 mV against steel. In vitro results: Electrodes are stable for at least 6 days. They exhibit a linear range extending to 500 mg/dl glucose. Response times are less than 100 sec. The sensors are not dependent on stirring and are relatively insensitive to changes of pH. Dependency of glucose measurement upon dissolved oxygen is negligible at oxygen concentrations above 0.5 mg/l. In vivo results: Preliminary studies in sheep using subcutaneously implanted needles indicate that short term glucose monitoring is feasible.

    Grapherence [↓2]

    Authors+Show Affiliations

    Kerner W
    ,

    Abteilung für Innere Medizin I, Universität Ulm.

    Zier H
    ,
    Steinbach G
    ,
    Brückel J
    ,
    Pfeiffer EF
    ,
    Weiss T
    ,
    Cammann K
    ,
    Planck H

    Source

    MeSH

    Animals
    Biosensing Techniques
    Blood Glucose
    Blood Glucose Self-Monitoring
    Electrochemistry
    Electrodes
    Glucose
    Glucose Oxidase
    Prostheses and Implants
    Sheep

    Pub Type(s)

    Comparative Study
    Journal Article

    Language

    eng

    PubMed ID

    3248792

    Citation

    Kerner, W, et al. "A Potentially Implantable Enzyme Electrode for Amperometric Measurement of Glucose." Hormone and Metabolic Research. Supplement Series, vol. 20, 1988, pp. 8-13.
    Kerner W, Zier H, Steinbach G, et al. A potentially implantable enzyme electrode for amperometric measurement of glucose. Horm Metab Res Suppl. 1988;20:8-13.
    Kerner, W., Zier, H., Steinbach, G., Brückel, J., Pfeiffer, E. F., Weiss, T., ... Planck, H. (1988). A potentially implantable enzyme electrode for amperometric measurement of glucose. Hormone and Metabolic Research. Supplement Series, 20, pp. 8-13.
    Kerner W, et al. A Potentially Implantable Enzyme Electrode for Amperometric Measurement of Glucose. Horm Metab Res Suppl. 1988;20:8-13. PubMed PMID: 3248792.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - A potentially implantable enzyme electrode for amperometric measurement of glucose. AU - Kerner,W, AU - Zier,H, AU - Steinbach,G, AU - Brückel,J, AU - Pfeiffer,E F, AU - Weiss,T, AU - Cammann,K, AU - Planck,H, PY - 1988/1/1/pubmed PY - 1988/1/1/medline PY - 1988/1/1/entrez SP - 8 EP - 13 JF - Hormone and metabolic research. Supplement series JO - Horm. Metab. Res. Suppl. VL - 20 N2 - A membrane limited amperometric enzyme electrode suitable for glucose measurement in biological fluids was developed. The sensor consists of a central platinum wire (0.3 mm) surrounded by a stainless steel tubing (0.8-1.0 mm outer diameter; 2-4 cm length). By successive dipcoating procedures, layers from cellulose acetate, glucose oxidase (crosslinked with glutaraldehyde) and polyurethane are placed on its surface. The platinum is polarized at +700 mV against steel. In vitro results: Electrodes are stable for at least 6 days. They exhibit a linear range extending to 500 mg/dl glucose. Response times are less than 100 sec. The sensors are not dependent on stirring and are relatively insensitive to changes of pH. Dependency of glucose measurement upon dissolved oxygen is negligible at oxygen concentrations above 0.5 mg/l. In vivo results: Preliminary studies in sheep using subcutaneously implanted needles indicate that short term glucose monitoring is feasible. SN - 0170-5903 UR - https://www.unboundmedicine.com/medline/citation/3248792/abstract/A_potentially_implantable_enzyme_electrode_for_amperometric_measurement_of_glucose_ L2 - https://www.lens.org/lens/search?q=citation_id:3248792 DB - PRIME DP - Unbound Medicine ER -