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Zanthoxylum nitidum (Roxb.) DC: Traditional uses, phytochemistry, pharmacological activities and toxicology.
J Ethnopharmacol. 2020 May 31; 260:112946.JE

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE

Zanthoxylum nitidum (Roxb.) DC. (Z. nitidum), which is known in China as Liang-Mian-Zhen, is mainly distributed in southern China and is widely used in traditional Chinese medicine. It is traditionally used for treating stomach ache, toothache, rheumatic arthralgia, traumatic injury and venomous snake bites. Additional medical applications include the treatment of inflammations, various types of cancer, bacterial and viral infections, gastric and oral ulcers and liver damage.

AIM OF THIS REVIEW

This paper aims to offer up-to-date information on the botany, traditional uses, phytochemistry, pharmacology and toxicity of Z. nitidum. This review also discussed the perspectives for possible future research on Z. nitidum.

MATERIALS AND METHODS

A comprehensive review was carried out on studies about Z. nitidum conducted in the past 60 years by using different resources, including Flora of China, Pharmacopoeia of the People's Republic of China and academic databases.

RESULTS

At present, more than 150 chemical constituents have been separated and identified from Z. nitidum, most of which include alkaloids. Biological activities, including anti-inflammation, analgesia, haemostasis, anticancer and antibacterial, were determined via in vitro and in vivo studies. The variations in the efficacy of Z. nitidum can be attributed to the biological activities of its natural products, especially alkaloids. Toxicity studies on Z. nitidum are relatively few, thus requiring further study.

CONCLUSIONS

This article generalises the current research achievements related to Z. nitidum, which is an important medicinal material in China. Some traditional uses of Z. nitidum have been assessed by pharmacological studies. Unresolved problems remain, including molecular mechanisms underlying biological activities, pharmacokinetics, toxicology and therapeutic effect, which are still being studied and explored before Z. nitidum can be integrated into clinical medicine.

Authors+Show Affiliations

Department of Pharmaceutical Sciences, Zunyi Medical University, Zhuhai Campus, Zhuhai, 519041, PR China.Department of Pharmaceutical Sciences, Zunyi Medical University, Zhuhai Campus, Zhuhai, 519041, PR China.Department of Pharmaceutical Sciences, Zunyi Medical University, Zhuhai Campus, Zhuhai, 519041, PR China.Department of Pharmaceutical Sciences, Zunyi Medical University, Zhuhai Campus, Zhuhai, 519041, PR China.Department of Pharmaceutical Sciences, Zunyi Medical University, Zhuhai Campus, Zhuhai, 519041, PR China.Department of Pharmacology, Zunyi Medical University, Zhuhai Campus, Zhuhai, 519041, PR China. Electronic address: licailan@zmu.edu.cn.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32492492

Citation

Lu, Qiang, et al. "Zanthoxylum Nitidum (Roxb.) DC: Traditional Uses, Phytochemistry, Pharmacological Activities and Toxicology." Journal of Ethnopharmacology, vol. 260, 2020, p. 112946.
Lu Q, Ma R, Yang Y, et al. Zanthoxylum nitidum (Roxb.) DC: Traditional uses, phytochemistry, pharmacological activities and toxicology. J Ethnopharmacol. 2020;260:112946.
Lu, Q., Ma, R., Yang, Y., Mo, Z., Pu, X., & Li, C. (2020). Zanthoxylum nitidum (Roxb.) DC: Traditional uses, phytochemistry, pharmacological activities and toxicology. Journal of Ethnopharmacology, 260, 112946. https://doi.org/10.1016/j.jep.2020.112946
Lu Q, et al. Zanthoxylum Nitidum (Roxb.) DC: Traditional Uses, Phytochemistry, Pharmacological Activities and Toxicology. J Ethnopharmacol. 2020 May 31;260:112946. PubMed PMID: 32492492.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Zanthoxylum nitidum (Roxb.) DC: Traditional uses, phytochemistry, pharmacological activities and toxicology. AU - Lu,Qiang, AU - Ma,Runfang, AU - Yang,Yang, AU - Mo,Zhimi, AU - Pu,Xudong, AU - Li,Cailan, Y1 - 2020/05/31/ PY - 2020/02/21/received PY - 2020/04/07/revised PY - 2020/05/01/accepted PY - 2020/6/4/pubmed PY - 2020/6/4/medline PY - 2020/6/4/entrez KW - Analgesic activity KW - Antimicrobial activity KW - Antiviral activity KW - Pharmacology KW - Phytochemicals KW - Zanthoxylum nitidum SP - 112946 EP - 112946 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 260 N2 - ETHNOPHARMACOLOGICAL RELEVANCE: Zanthoxylum nitidum (Roxb.) DC. (Z. nitidum), which is known in China as Liang-Mian-Zhen, is mainly distributed in southern China and is widely used in traditional Chinese medicine. It is traditionally used for treating stomach ache, toothache, rheumatic arthralgia, traumatic injury and venomous snake bites. Additional medical applications include the treatment of inflammations, various types of cancer, bacterial and viral infections, gastric and oral ulcers and liver damage. AIM OF THIS REVIEW: This paper aims to offer up-to-date information on the botany, traditional uses, phytochemistry, pharmacology and toxicity of Z. nitidum. This review also discussed the perspectives for possible future research on Z. nitidum. MATERIALS AND METHODS: A comprehensive review was carried out on studies about Z. nitidum conducted in the past 60 years by using different resources, including Flora of China, Pharmacopoeia of the People's Republic of China and academic databases. RESULTS: At present, more than 150 chemical constituents have been separated and identified from Z. nitidum, most of which include alkaloids. Biological activities, including anti-inflammation, analgesia, haemostasis, anticancer and antibacterial, were determined via in vitro and in vivo studies. The variations in the efficacy of Z. nitidum can be attributed to the biological activities of its natural products, especially alkaloids. Toxicity studies on Z. nitidum are relatively few, thus requiring further study. CONCLUSIONS: This article generalises the current research achievements related to Z. nitidum, which is an important medicinal material in China. Some traditional uses of Z. nitidum have been assessed by pharmacological studies. Unresolved problems remain, including molecular mechanisms underlying biological activities, pharmacokinetics, toxicology and therapeutic effect, which are still being studied and explored before Z. nitidum can be integrated into clinical medicine. SN - 1872-7573 UR - https://www.unboundmedicine.com/medline/citation/32492492/Zanthoxylum_nitidum_(Roxb.)_DC:_Traditional_uses,_phytochemistry,_pharmacological_activities_and_toxicology L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(20)30813-8 DB - PRIME DP - Unbound Medicine ER -
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