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How to improve the histopathological diagnosis of systemic vasculitides in daily practice?
Cesk Patol. 2020 Spring; 56(2):68-73.CP

Abstract

The most common group of systemic vasculitides in adulthood are anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). AAV represent autoimmune systemic vasculitides and include 3 clinical phenotypes: Granulomatosis with polyangiitis (GPA, formerly Wegener granulomatosis), Microscopic polyangiitis (MPA) and Eosinophilic granulomatosis with polyangiitis (EGPA, formerly Churg-Strauss syndrome). Histological features are similar to each other in all affected locations, and there are represented by necrotizing vascular inflammation of small and medium calibers, often venules, capillaries or arteriols, typically with fibrinoid vessel wall necrosis. The consequences of this condition are bleeding, as well as compromise of the lumen which may result in downstream tissue ischemia and necrosis. Typically affected locations in biopsy practice are: ENT, lung, skin, GIT, and kidney. The aim of this review is to provide a comprehensive overview of the important histopathological findings. ANCA positive vasculitis is a serious life-threatening disease and therefore requires a rapid diagnosis and appropriate therapy.

Authors

No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32493022

Citation

Honsová, Eva. "How to Improve the Histopathological Diagnosis of Systemic Vasculitides in Daily Practice?" Ceskoslovenska Patologie, vol. 56, no. 2, 2020, pp. 68-73.
Honsová E. How to improve the histopathological diagnosis of systemic vasculitides in daily practice? Cesk Patol. 2020;56(2):68-73.
Honsová, E. (2020). How to improve the histopathological diagnosis of systemic vasculitides in daily practice? Ceskoslovenska Patologie, 56(2), 68-73.
Honsová E. How to Improve the Histopathological Diagnosis of Systemic Vasculitides in Daily Practice. Cesk Patol. 2020;56(2):68-73. PubMed PMID: 32493022.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - How to improve the histopathological diagnosis of systemic vasculitides in daily practice? A1 - Honsová,Eva, PY - 2020/6/5/entrez KW - ANCA positive vasculitis KW - GPA KW - MPA KW - histopathology SP - 68 EP - 73 JF - Ceskoslovenska patologie JO - Cesk Patol VL - 56 IS - 2 N2 - The most common group of systemic vasculitides in adulthood are anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). AAV represent autoimmune systemic vasculitides and include 3 clinical phenotypes: Granulomatosis with polyangiitis (GPA, formerly Wegener granulomatosis), Microscopic polyangiitis (MPA) and Eosinophilic granulomatosis with polyangiitis (EGPA, formerly Churg-Strauss syndrome). Histological features are similar to each other in all affected locations, and there are represented by necrotizing vascular inflammation of small and medium calibers, often venules, capillaries or arteriols, typically with fibrinoid vessel wall necrosis. The consequences of this condition are bleeding, as well as compromise of the lumen which may result in downstream tissue ischemia and necrosis. Typically affected locations in biopsy practice are: ENT, lung, skin, GIT, and kidney. The aim of this review is to provide a comprehensive overview of the important histopathological findings. ANCA positive vasculitis is a serious life-threatening disease and therefore requires a rapid diagnosis and appropriate therapy. SN - 1210-7875 UR - https://www.unboundmedicine.com/medline/citation/32493022/How_to_improve_the_histopathological_diagnosis_of_systemic_vasculitides_in_daily_practice L2 - https://www.prolekare.cz/linkout/122428 DB - PRIME DP - Unbound Medicine ER -
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