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SARS-CoV-2 SPIKE PROTEIN: an optimal immunological target for vaccines.
J Transl Med. 2020 Jun 03; 18(1):222.JT

Abstract

COVID-19 has rapidly spread all over the world, progressing into a pandemic. This situation has urgently impelled many companies and public research institutes to concentrate their efforts on research for effective therapeutics. Here, we outline the strategies and targets currently adopted in developing a vaccine against SARS-CoV-2. Based on previous evidence and experience with SARS and MERS, the primary focus has been the Spike protein, considered as the ideal target for COVID-19 immunotherapies.

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Authors+Show Affiliations

Salvatori G
Takis s.r.l, Via di Castel Romano 100, 00128, Rome, Italy.
Luberto L
Takis s.r.l, Via di Castel Romano 100, 00128, Rome, Italy.
Maffei M
Evvivax s.r.l, Via di Castel Romano, 100, 00128, Rome, Italy.
Aurisicchio L
Takis s.r.l, Via di Castel Romano 100, 00128, Rome, Italy. Evvivax s.r.l, Via di Castel Romano, 100, 00128, Rome, Italy.
Roscilli G
Takis s.r.l, Via di Castel Romano 100, 00128, Rome, Italy. Evvivax s.r.l, Via di Castel Romano, 100, 00128, Rome, Italy.
Palombo F
Takis s.r.l, Via di Castel Romano 100, 00128, Rome, Italy.
Marra E
Takis s.r.l, Via di Castel Romano 100, 00128, Rome, Italy. marra@takisbiotech.it. Evvivax s.r.l, Via di Castel Romano, 100, 00128, Rome, Italy. marra@takisbiotech.it.

MeSH

AnimalsAntibodies, ViralAntibody-Dependent EnhancementBetacoronavirusCOVID-19COVID-19 VaccinesCoronavirus InfectionsHumansPandemicsPneumonia, ViralSARS-CoV-2Spike Glycoprotein, CoronavirusTranslational Research, BiomedicalViral Vaccines

Pub Type(s)

Letter

Language

eng

PubMed ID

32493510

Citation

Salvatori, Giovanni, et al. "SARS-CoV-2 SPIKE PROTEIN: an Optimal Immunological Target for Vaccines." Journal of Translational Medicine, vol. 18, no. 1, 2020, p. 222.
Salvatori G, Luberto L, Maffei M, et al. SARS-CoV-2 SPIKE PROTEIN: an optimal immunological target for vaccines. J Transl Med. 2020;18(1):222.
Salvatori, G., Luberto, L., Maffei, M., Aurisicchio, L., Roscilli, G., Palombo, F., & Marra, E. (2020). SARS-CoV-2 SPIKE PROTEIN: an optimal immunological target for vaccines. Journal of Translational Medicine, 18(1), 222. https://doi.org/10.1186/s12967-020-02392-y
Salvatori G, et al. SARS-CoV-2 SPIKE PROTEIN: an Optimal Immunological Target for Vaccines. J Transl Med. 2020 Jun 3;18(1):222. PubMed PMID: 32493510.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - SARS-CoV-2 SPIKE PROTEIN: an optimal immunological target for vaccines. AU - Salvatori,Giovanni, AU - Luberto,Laura, AU - Maffei,Mariano, AU - Aurisicchio,Luigi, AU - Roscilli,Giuseppe, AU - Palombo,Fabio, AU - Marra,Emanuele, Y1 - 2020/06/03/ PY - 2020/4/22/received PY - 2020/5/28/accepted PY - 2020/6/5/entrez PY - 2020/6/5/pubmed PY - 2020/6/17/medline KW - SARS-CoV-2 KW - SPIKE protein KW - Vaccine SP - 222 EP - 222 JF - Journal of translational medicine JO - J Transl Med VL - 18 IS - 1 N2 - COVID-19 has rapidly spread all over the world, progressing into a pandemic. This situation has urgently impelled many companies and public research institutes to concentrate their efforts on research for effective therapeutics. Here, we outline the strategies and targets currently adopted in developing a vaccine against SARS-CoV-2. Based on previous evidence and experience with SARS and MERS, the primary focus has been the Spike protein, considered as the ideal target for COVID-19 immunotherapies. SN - 1479-5876 UR - https://www.unboundmedicine.com/medline/citation/32493510/SARS_CoV_2_SPIKE_PROTEIN:_an_optimal_immunological_target_for_vaccines_ DB - PRIME DP - Unbound Medicine ER -