Tags

Type your tag names separated by a space and hit enter

Role of Aging and the Immune Response to Respiratory Viral Infections: Potential Implications for COVID-19.
J Immunol. 2020 Jul 15; 205(2):313-320.JI

Abstract

Aging impairs immunity to promote diseases, especially respiratory viral infections. The current COVID-19 pandemic, resulting from SARS-CoV-2, induces acute pneumonia, a phenotype that is alarmingly increased with aging. In this article, we review findings of how aging alters immunity to respiratory viral infections to identify age-impacted pathways common to several viral pathogens, permitting us to speculate about potential mechanisms of age-enhanced mortality to COVID-19. Aging generally leads to exaggerated innate immunity, particularly in the form of elevated neutrophil accumulation across murine and large animal studies of influenza infection. COVID-19 patients who succumb exhibit a 2-fold increase in neutrophilia, suggesting that exaggerated innate immunity contributes to age-enhanced mortality to SARS-CoV-2 infection. Further investigation in relevant experimental models will elucidate the mechanisms by which aging impacts respiratory viral infections, including SARS-CoV-2. Such investigation could identify therapies to reduce the suffering of the population at large, but especially among older people, infected with respiratory viruses.

Links

PMC Free PDF

Authors+Show Affiliations

Chen J
Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109. Program in Immunology, University of Michigan, Ann Arbor, MI 48109; and.
Kelley WJ
Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109.
Goldstein DR
Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109; drgoldst@umich.edu. Program in Immunology, University of Michigan, Ann Arbor, MI 48109; and. Department of Microbiology and Immunology, University of Michigan, Ann Arbor, MI 48109.

MeSH

AgingBetacoronavirusCOVID-19Cardiovascular DiseasesCoronavirus InfectionsCytokinesHumansInfluenza, HumanPandemicsPneumonia, ViralRespiratory Tract InfectionsSevere acute respiratory syndrome-related coronavirusSARS-CoV-2

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Review

Language

eng

PubMed ID

32493812

Citation

Chen, Judy, et al. "Role of Aging and the Immune Response to Respiratory Viral Infections: Potential Implications for COVID-19." Journal of Immunology (Baltimore, Md. : 1950), vol. 205, no. 2, 2020, pp. 313-320.
Chen J, Kelley WJ, Goldstein DR. Role of Aging and the Immune Response to Respiratory Viral Infections: Potential Implications for COVID-19. J Immunol. 2020;205(2):313-320.
Chen, J., Kelley, W. J., & Goldstein, D. R. (2020). Role of Aging and the Immune Response to Respiratory Viral Infections: Potential Implications for COVID-19. Journal of Immunology (Baltimore, Md. : 1950), 205(2), 313-320. https://doi.org/10.4049/jimmunol.2000380
Chen J, Kelley WJ, Goldstein DR. Role of Aging and the Immune Response to Respiratory Viral Infections: Potential Implications for COVID-19. J Immunol. 2020 Jul 15;205(2):313-320. PubMed PMID: 32493812.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role of Aging and the Immune Response to Respiratory Viral Infections: Potential Implications for COVID-19. AU - Chen,Judy, AU - Kelley,William J, AU - Goldstein,Daniel R, Y1 - 2020/06/03/ PY - 2020/4/6/received PY - 2020/5/15/accepted PY - 2020/6/5/pubmed PY - 2020/7/15/medline PY - 2020/6/5/entrez SP - 313 EP - 320 JF - Journal of immunology (Baltimore, Md. : 1950) JO - J Immunol VL - 205 IS - 2 N2 - Aging impairs immunity to promote diseases, especially respiratory viral infections. The current COVID-19 pandemic, resulting from SARS-CoV-2, induces acute pneumonia, a phenotype that is alarmingly increased with aging. In this article, we review findings of how aging alters immunity to respiratory viral infections to identify age-impacted pathways common to several viral pathogens, permitting us to speculate about potential mechanisms of age-enhanced mortality to COVID-19. Aging generally leads to exaggerated innate immunity, particularly in the form of elevated neutrophil accumulation across murine and large animal studies of influenza infection. COVID-19 patients who succumb exhibit a 2-fold increase in neutrophilia, suggesting that exaggerated innate immunity contributes to age-enhanced mortality to SARS-CoV-2 infection. Further investigation in relevant experimental models will elucidate the mechanisms by which aging impacts respiratory viral infections, including SARS-CoV-2. Such investigation could identify therapies to reduce the suffering of the population at large, but especially among older people, infected with respiratory viruses. SN - 1550-6606 UR - https://www.unboundmedicine.com/medline/citation/32493812/Role_of_Aging_and_the_Immune_Response_to_Respiratory_Viral_Infections:_Potential_Implications_for_COVID_19_ DB - PRIME DP - Unbound Medicine ER -