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Acute Hypersensitivity Pneumonitis Associated With a High Ki-67 Proliferative Index.
Cureus. 2020 Apr 30; 12(4):e7905.C

Abstract

Hypersensitivity pneumonitis (HSP) is an interstitial lung disease caused by exposure to a large range of environmental antigens. Inhaling aerosolized particles leads to a heightened immune response. HSP comes in acute, subacute, or chronic forms, all with their own potential clinical and radiographic findings. Mycobacterium avium complex (MAC) is the most common nontuberculous mycobacteria and is known to cause HSP with certain exposures. However, although certain histologic findings can be seen with HSP, a high ki-67 proliferation index is unusual and more commonly associated with malignancy. In this report, we discuss a case of MAC that had acute HSP associated with a high ki-67 proliferative index.

Authors+Show Affiliations

Internal Medicine, Advocate Lutheran General Hospital, Park Ridge, USA.Internal Medicine, Advocate Lutheran General Hospital, Park Ridge, USA.Pathology, University of Illinois, Chicago, USA.Pathology, Advocate Lutheran General Hospital, Park Ridge, USA.Pulmonary and Critical Care Medicine, Advocate Lutheran General Hospital, Park Ridge, USA.

Pub Type(s)

Case Reports

Language

eng

PubMed ID

32494520

Citation

Nabrinsky, Edward, et al. "Acute Hypersensitivity Pneumonitis Associated With a High Ki-67 Proliferative Index." Cureus, vol. 12, no. 4, 2020, pp. e7905.
Nabrinsky E, Kamar A, Mohammed Saeed D, et al. Acute Hypersensitivity Pneumonitis Associated With a High Ki-67 Proliferative Index. Cureus. 2020;12(4):e7905.
Nabrinsky, E., Kamar, A., Mohammed Saeed, D., Pins, M., & Stone, A. (2020). Acute Hypersensitivity Pneumonitis Associated With a High Ki-67 Proliferative Index. Cureus, 12(4), e7905. https://doi.org/10.7759/cureus.7905
Nabrinsky E, et al. Acute Hypersensitivity Pneumonitis Associated With a High Ki-67 Proliferative Index. Cureus. 2020 Apr 30;12(4):e7905. PubMed PMID: 32494520.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Acute Hypersensitivity Pneumonitis Associated With a High Ki-67 Proliferative Index. AU - Nabrinsky,Edward, AU - Kamar,Amanda, AU - Mohammed Saeed,Dereen, AU - Pins,Michael, AU - Stone,Arvey, Y1 - 2020/04/30/ PY - 2020/6/5/entrez PY - 2020/6/5/pubmed PY - 2020/6/5/medline KW - hsp KW - hypersensitivity pneumonitis KW - immunohistochemistry KW - ki-67 KW - mac KW - mycobacterium KW - mycobacterium avium complex KW - proliferation SP - e7905 EP - e7905 JF - Cureus JO - Cureus VL - 12 IS - 4 N2 - Hypersensitivity pneumonitis (HSP) is an interstitial lung disease caused by exposure to a large range of environmental antigens. Inhaling aerosolized particles leads to a heightened immune response. HSP comes in acute, subacute, or chronic forms, all with their own potential clinical and radiographic findings. Mycobacterium avium complex (MAC) is the most common nontuberculous mycobacteria and is known to cause HSP with certain exposures. However, although certain histologic findings can be seen with HSP, a high ki-67 proliferation index is unusual and more commonly associated with malignancy. In this report, we discuss a case of MAC that had acute HSP associated with a high ki-67 proliferative index. SN - 2168-8184 UR - https://www.unboundmedicine.com/medline/citation/32494520/Acute_Hypersensitivity_Pneumonitis_Associated_With_a_High_Ki-67_Proliferative_Index DB - PRIME DP - Unbound Medicine ER -
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