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Clinical characteristics of two human-to-human transmitted coronaviruses: Corona Virus Disease 2019 vs. Middle East Respiratory Syndrome Coronavirus.
Eur Rev Med Pharmacol Sci. 2020 05; 24(10):5797-5809.ER

Abstract

OBJECTIVE

Subsequent to a global outbreak of the Middle East Respiratory Syndrome (MERS) in 2012, a novel human coronavirus, known as Corona Virus Disease 2019 (COVID-19) has caused a major disease outbreak. The aim of this study was to perform a systematic review to compare epidemiological, clinical, and laboratory features of COVID-19 and MERS-COV populations.

MATERIALS AND METHODS

We searched PubMed, EMBASE, and Cochrane Central Register of Controlled Trials database to identify potential studies that have reported COVID-19 or MERS-COV disease. Epidemiology, clinical, and laboratory outcomes, intensive care unit (ICU) admission rates, discharge rates, and fatality rates were evaluated using Graph-Pad Prism software.

RESULTS

A total of forty-two studies were included in our research, involving in 4,720 patients (COVID-19 = 2,012, MERS-COV = 2,708). The present study revealed that main clinical manifestations of both COVID-19 and MERS-COV populations are fever, cough and generalized weakness or myalgia, and Acute Respiratory Distress Syndrome (ARDS) is the main complication. The COVID-19 population has a lower rate of ICU admissions, discharges, fatalities, and shorter incubation periods than those of MERS-COV population.

CONCLUSIONS

The main clinical features of both COVID-19 and MERS-COV populations are fever, cough and generalized weakness or myalgia. ARDS is the main complication of both populations. COVID-19 cases have a shorter incubation period and lower rate of ICU admissions, discharges and fatalities compared to MRES-COV population.

Authors+Show Affiliations

Department of Spinal Surgery, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, People's Republic of China. lizhizhonghy@163.com.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Systematic Review

Language

eng

PubMed ID

32495918

Citation

Xu, P, et al. "Clinical Characteristics of Two Human-to-human Transmitted Coronaviruses: Corona Virus Disease 2019 Vs. Middle East Respiratory Syndrome Coronavirus." European Review for Medical and Pharmacological Sciences, vol. 24, no. 10, 2020, pp. 5797-5809.
Xu P, Sun GD, Li ZZ. Clinical characteristics of two human-to-human transmitted coronaviruses: Corona Virus Disease 2019 vs. Middle East Respiratory Syndrome Coronavirus. Eur Rev Med Pharmacol Sci. 2020;24(10):5797-5809.
Xu, P., Sun, G. D., & Li, Z. Z. (2020). Clinical characteristics of two human-to-human transmitted coronaviruses: Corona Virus Disease 2019 vs. Middle East Respiratory Syndrome Coronavirus. European Review for Medical and Pharmacological Sciences, 24(10), 5797-5809. https://doi.org/10.26355/eurrev_202005_21374
Xu P, Sun GD, Li ZZ. Clinical Characteristics of Two Human-to-human Transmitted Coronaviruses: Corona Virus Disease 2019 Vs. Middle East Respiratory Syndrome Coronavirus. Eur Rev Med Pharmacol Sci. 2020;24(10):5797-5809. PubMed PMID: 32495918.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical characteristics of two human-to-human transmitted coronaviruses: Corona Virus Disease 2019 vs. Middle East Respiratory Syndrome Coronavirus. AU - Xu,P, AU - Sun,G-D, AU - Li,Z-Z, PY - 2020/6/5/entrez PY - 2020/6/5/pubmed PY - 2020/6/11/medline SP - 5797 EP - 5809 JF - European review for medical and pharmacological sciences JO - Eur Rev Med Pharmacol Sci VL - 24 IS - 10 N2 - OBJECTIVE: Subsequent to a global outbreak of the Middle East Respiratory Syndrome (MERS) in 2012, a novel human coronavirus, known as Corona Virus Disease 2019 (COVID-19) has caused a major disease outbreak. The aim of this study was to perform a systematic review to compare epidemiological, clinical, and laboratory features of COVID-19 and MERS-COV populations. MATERIALS AND METHODS: We searched PubMed, EMBASE, and Cochrane Central Register of Controlled Trials database to identify potential studies that have reported COVID-19 or MERS-COV disease. Epidemiology, clinical, and laboratory outcomes, intensive care unit (ICU) admission rates, discharge rates, and fatality rates were evaluated using Graph-Pad Prism software. RESULTS: A total of forty-two studies were included in our research, involving in 4,720 patients (COVID-19 = 2,012, MERS-COV = 2,708). The present study revealed that main clinical manifestations of both COVID-19 and MERS-COV populations are fever, cough and generalized weakness or myalgia, and Acute Respiratory Distress Syndrome (ARDS) is the main complication. The COVID-19 population has a lower rate of ICU admissions, discharges, fatalities, and shorter incubation periods than those of MERS-COV population. CONCLUSIONS: The main clinical features of both COVID-19 and MERS-COV populations are fever, cough and generalized weakness or myalgia. ARDS is the main complication of both populations. COVID-19 cases have a shorter incubation period and lower rate of ICU admissions, discharges and fatalities compared to MRES-COV population. SN - 2284-0729 UR - https://www.unboundmedicine.com/medline/citation/32495918/Clinical_characteristics_of_two_human_to_human_transmitted_coronaviruses:_Corona_Virus_Disease_2019_vs__Middle_East_Respiratory_Syndrome_Coronavirus_ DB - PRIME DP - Unbound Medicine ER -