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An update on novel COVID-19 pandemic: a battle between humans and virus.
Eur Rev Med Pharmacol Sci. 2020 May; 24(10):5819-5829.ER

Abstract

In the 21st century, human civilization has witnessed three major epidemics caused by Coronaviruses namely severe acute respiratory syndrome coronavirus (SARS CoV) in 2003, Middle East respiratory syndrome coronavirus (MERS CoV) in 2012 and 2019 novel coronavirus (2019 nCoV) or coronavirus disease (COVID 19) in 2019. Among these, COVID-19 has greater transmission and mortality rate. 2019 nCoV belongs to a large family of positive sense single-stranded RNA viruses (+ssRNA) that can be isolated in different animal species. The most communal symptoms of COVID-19 include fever, cough, and shortness of breath during the incubation period (2-14 days) of infection. COVID-19 transmission is occurring from infected humans to close contact with one another through respiratory droplets, coughs, and sneezes of infected person. Moreover, the virus containing surfaces may also transmit the infection. Diagnosis is being carried out by collecting a nasopharyngeal swab or sputum specimen for detection of SARS-CoV-2 RNA by reverse-transcription polymerase chain reaction (RT-PCR). Rapid diagnosing methods are also under development which can diagnose COVID 19 in few minutes to hours. Currently, there is no specific cure or preventive therapeutics available. Hence, based upon limited in-vitro and anecdotal data, Chloroquine, or Hydroxychloroquine, Remdesivir, Lopinavir and Ritonavir are being employed in the management. Search for new specific anti-viral drugs from natural/synthetic origins is under full swing and many of them are currently used as chemotherapeutic drugs under clinical investigation. Yet, there is a strong need for development of vaccine, which may take several months to few years for the development.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Prajapati S
Dr. DP Rastogi Central Research Institute for Homeopathy, Noida, Uttar Pradesh, India. saimpj@gmail.com.
Sharma M
No affiliation info available
Kumar A
No affiliation info available
Gupta P
No affiliation info available
Narasimha Kumar GV
No affiliation info available

MeSH

Adenosine MonophosphateAlanineAntiviral AgentsBetacoronavirusCOVID-19Coronavirus InfectionsHumansPandemicsPneumonia, ViralRNA, ViralRespiratory Distress SyndromeSARS-CoV-2Survival Analysis

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32495921

Citation

Prajapati, S, et al. "An Update On Novel COVID-19 Pandemic: a Battle Between Humans and Virus." European Review for Medical and Pharmacological Sciences, vol. 24, no. 10, 2020, pp. 5819-5829.
Prajapati S, Sharma M, Kumar A, et al. An update on novel COVID-19 pandemic: a battle between humans and virus. Eur Rev Med Pharmacol Sci. 2020;24(10):5819-5829.
Prajapati, S., Sharma, M., Kumar, A., Gupta, P., & Narasimha Kumar, G. V. (2020). An update on novel COVID-19 pandemic: a battle between humans and virus. European Review for Medical and Pharmacological Sciences, 24(10), 5819-5829. https://doi.org/10.26355/eurrev_202005_21377
Prajapati S, et al. An Update On Novel COVID-19 Pandemic: a Battle Between Humans and Virus. Eur Rev Med Pharmacol Sci. 2020;24(10):5819-5829. PubMed PMID: 32495921.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - An update on novel COVID-19 pandemic: a battle between humans and virus. AU - Prajapati,S, AU - Sharma,M, AU - Kumar,A, AU - Gupta,P, AU - Narasimha Kumar,G V, PY - 2020/6/5/entrez PY - 2020/6/5/pubmed PY - 2020/6/11/medline SP - 5819 EP - 5829 JF - European review for medical and pharmacological sciences JO - Eur Rev Med Pharmacol Sci VL - 24 IS - 10 N2 - In the 21st century, human civilization has witnessed three major epidemics caused by Coronaviruses namely severe acute respiratory syndrome coronavirus (SARS CoV) in 2003, Middle East respiratory syndrome coronavirus (MERS CoV) in 2012 and 2019 novel coronavirus (2019 nCoV) or coronavirus disease (COVID 19) in 2019. Among these, COVID-19 has greater transmission and mortality rate. 2019 nCoV belongs to a large family of positive sense single-stranded RNA viruses (+ssRNA) that can be isolated in different animal species. The most communal symptoms of COVID-19 include fever, cough, and shortness of breath during the incubation period (2-14 days) of infection. COVID-19 transmission is occurring from infected humans to close contact with one another through respiratory droplets, coughs, and sneezes of infected person. Moreover, the virus containing surfaces may also transmit the infection. Diagnosis is being carried out by collecting a nasopharyngeal swab or sputum specimen for detection of SARS-CoV-2 RNA by reverse-transcription polymerase chain reaction (RT-PCR). Rapid diagnosing methods are also under development which can diagnose COVID 19 in few minutes to hours. Currently, there is no specific cure or preventive therapeutics available. Hence, based upon limited in-vitro and anecdotal data, Chloroquine, or Hydroxychloroquine, Remdesivir, Lopinavir and Ritonavir are being employed in the management. Search for new specific anti-viral drugs from natural/synthetic origins is under full swing and many of them are currently used as chemotherapeutic drugs under clinical investigation. Yet, there is a strong need for development of vaccine, which may take several months to few years for the development. SN - 2284-0729 UR - https://www.unboundmedicine.com/medline/citation/32495921/An_update_on_novel_COVID_19_pandemic:_a_battle_between_humans_and_virus_ DB - PRIME DP - Unbound Medicine ER -