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COVID-19: a conundrum to decipher.
Eur Rev Med Pharmacol Sci. 2020 May; 24(10):5830-5841.ER

Abstract

OBJECTIVE

Recent worldwide outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of respiratory coronavirus disease 2019 (COVID-19), is a current, ongoing life-threatening crisis, and international public health emergency. The early diagnosis and management of the disease remains a major challenge. In this review, we aim to summarize the updated epidemiology, causes, clinical manifestation and diagnosis, as well as prevention and control of the novel coronavirus SARS-CoV-2.

MATERIALS AND METHODS

A broad search of the literature was performed in "PubMed" "Medline" "Web of Science", "Google Scholar" and "World Health Organization-WHO" using the keywords "severe acute respiratory syndrome coronavirus", "2019-nCoV", "COVID-19, "SARS", "SARS-CoV-2" "Epidemiology" "Transmission" "Pathogenesis" "Clinical Characteristics". We reviewed and documented the information obtained from literature on epidemiology, pathogenesis and clinical appearances of SARS-CoV-2 infection.

RESULTS

The global cases of COVID-19 as of April 2, 2020, have risen to more than 900,000 and morbidity has reached more than 47,000. The incidence rate for COVID-19 has been predicted to be higher than the previous outbreaks of other coronavirus family members, including those of SARS-CoV and the Middle East Respiratory Syndrome Coronavirus (MERS-CoV). The main clinical presentation of SARS-CoV-2 infection ranges from asymptomatic stages to severe lower respiratory infection in the form of pneumonia. Most of the patients also presented with fever, cough, sore throat, headache, fatigue, myalgia and breathlessness. Individuals at higher risk for severe illness include elderly people and patients with a weakened immune system or that are suffering from an underlying chronic medical condition like hypertension, diabetes mellitus, cancer, respiratory illness or cardiovascular diseases.

CONCLUSIONS

SARS-Cov-2 has emerged as a worldwide threat, currently affecting 170 countries and territories across the globe. There is still much to be understood regarding SARS-CoV-2 about its virology, epidemiology and clinical management strategies; this knowledge will be essential to both manage the current pandemic and to conceive comprehensive measures to prevent such outbreaks in the future.

Authors+Show Affiliations

Department of Anatomy, Biochemistry; All India Institute of Medical Sciences, Nagpur, Maharashtra, India. sctripathi@aiimsnagpur.edu.in.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32495923

Citation

Deshmukh, V, et al. "COVID-19: a Conundrum to Decipher." European Review for Medical and Pharmacological Sciences, vol. 24, no. 10, 2020, pp. 5830-5841.
Deshmukh V, Tripathi SC, Pandey A, et al. COVID-19: a conundrum to decipher. Eur Rev Med Pharmacol Sci. 2020;24(10):5830-5841.
Deshmukh, V., Tripathi, S. C., Pandey, A., Deshmukh, V., Vykoukal, J., Patil, A., & Sontakke, B. (2020). COVID-19: a conundrum to decipher. European Review for Medical and Pharmacological Sciences, 24(10), 5830-5841. https://doi.org/10.26355/eurrev_202005_21378
Deshmukh V, et al. COVID-19: a Conundrum to Decipher. Eur Rev Med Pharmacol Sci. 2020;24(10):5830-5841. PubMed PMID: 32495923.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - COVID-19: a conundrum to decipher. AU - Deshmukh,V, AU - Tripathi,S C, AU - Pandey,A, AU - Deshmukh,V, AU - Vykoukal,J, AU - Patil,A, AU - Sontakke,B, PY - 2020/6/5/entrez PY - 2020/6/5/pubmed PY - 2020/6/11/medline SP - 5830 EP - 5841 JF - European review for medical and pharmacological sciences JO - Eur Rev Med Pharmacol Sci VL - 24 IS - 10 N2 - OBJECTIVE: Recent worldwide outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of respiratory coronavirus disease 2019 (COVID-19), is a current, ongoing life-threatening crisis, and international public health emergency. The early diagnosis and management of the disease remains a major challenge. In this review, we aim to summarize the updated epidemiology, causes, clinical manifestation and diagnosis, as well as prevention and control of the novel coronavirus SARS-CoV-2. MATERIALS AND METHODS: A broad search of the literature was performed in "PubMed" "Medline" "Web of Science", "Google Scholar" and "World Health Organization-WHO" using the keywords "severe acute respiratory syndrome coronavirus", "2019-nCoV", "COVID-19, "SARS", "SARS-CoV-2" "Epidemiology" "Transmission" "Pathogenesis" "Clinical Characteristics". We reviewed and documented the information obtained from literature on epidemiology, pathogenesis and clinical appearances of SARS-CoV-2 infection. RESULTS: The global cases of COVID-19 as of April 2, 2020, have risen to more than 900,000 and morbidity has reached more than 47,000. The incidence rate for COVID-19 has been predicted to be higher than the previous outbreaks of other coronavirus family members, including those of SARS-CoV and the Middle East Respiratory Syndrome Coronavirus (MERS-CoV). The main clinical presentation of SARS-CoV-2 infection ranges from asymptomatic stages to severe lower respiratory infection in the form of pneumonia. Most of the patients also presented with fever, cough, sore throat, headache, fatigue, myalgia and breathlessness. Individuals at higher risk for severe illness include elderly people and patients with a weakened immune system or that are suffering from an underlying chronic medical condition like hypertension, diabetes mellitus, cancer, respiratory illness or cardiovascular diseases. CONCLUSIONS: SARS-Cov-2 has emerged as a worldwide threat, currently affecting 170 countries and territories across the globe. There is still much to be understood regarding SARS-CoV-2 about its virology, epidemiology and clinical management strategies; this knowledge will be essential to both manage the current pandemic and to conceive comprehensive measures to prevent such outbreaks in the future. SN - 2284-0729 UR - https://www.unboundmedicine.com/medline/citation/32495923/COVID_19:_a_conundrum_to_decipher_ L2 - https://www.europeanreview.org/article/21378 DB - PRIME DP - Unbound Medicine ER -