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[Etiology of epidemic outbreaks COVID-19 on Wuhan, Hubei province, Chinese People Republic associated with 2019-nCoV (Nidovirales, Coronaviridae, Coronavirinae, Betacoronavirus, Subgenus Sarbecovirus): lessons of SARS-CoV outbreak.]
Vopr Virusol. 2020; 65(1):6-15.VV

Abstract

Results of analysis of phylogenetic, virological, epidemiological, ecological, clinical data of COVID-19 outbreaks in Wuhan, China (PRC) in comparison with SARS-2002 and MERS-2012 outbreaks allow to conclude: - the etiological agent of COVID-19 is coronavirus (2019-CoV), phylogenetically close to the SARS-CoV, isolated from human, and SARS-related viruses isolated from bats (SARS-related bat CoV viruses). These viruses belong to the Sarbecovirus subgenus, Betacoronavirus genus, Orthocoronavirinae subfamily, Coronaviridae family (Cornidovirinea: Nidovirales). COVID-19 is a variant of SARS-2002 and is different from MERS-2012 outbreak, which were caused by coronavirus belonged to the subgenus Merbecovirus of the same genus; - according to the results of phylogenetic analysis of 35 different betacoronaviruses, isolated from human and from wild animals in 2002-2019, the natural source of COVID-19 and SARS-CoV (2002) is bats of Rhinolophus genus (Rhinolophidae) and, probably, some species of other genera. An additional reservoir of the virus could be an intermediate animal species (snakes, civet, hedgehogs, badgers, etc.) that are infected by eating of infected bats. SARS-like coronaviruses circulated in bats in the interepidemic period (2003-2019); - seasonal coronaviruses (subgenus Duvinacovirus, Alphacoronavirus) are currently circulating (November 2019 - January 2020) in the European part of Russia, Urals, Siberia and the Far East of Russia, along with the influenza viruses A(H1N1)pdm09, A(H3N2), and В, as well as six other respiratory viruses (HPIV, HAdV, HRSV, HRV, HBoV, and HMPV).

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Publisher Full Text (DOI)

Authors+Show Affiliations

Lvov DK
D.I. Ivanovsky Institute of Virology of National Research Centre for Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya, Moscow, 123098, Russia.
Alkhovsky SV
D.I. Ivanovsky Institute of Virology of National Research Centre for Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya, Moscow, 123098, Russia.
Kolobukhina LV
D.I. Ivanovsky Institute of Virology of National Research Centre for Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya, Moscow, 123098, Russia.
Burtseva EI
D.I. Ivanovsky Institute of Virology of National Research Centre for Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya, Moscow, 123098, Russia.

MeSH

AnimalsBetacoronavirusCOVID-19ChinaChiropteraCoronavirus InfectionsDisease ReservoirsEpidemiological MonitoringHedgehogsHumansMustelidaePandemicsPhylogenyPneumonia, ViralPublic HealthRespiratory Tract InfectionsRussiaSARS-CoV-2SnakesViverridae

Pub Type(s)

Journal Article
Review

Language

rus

PubMed ID

32496715

Citation

Lvov, D K., et al. "[Etiology of Epidemic Outbreaks COVID-19 On Wuhan, Hubei Province, Chinese People Republic Associated With 2019-nCoV (Nidovirales, Coronaviridae, Coronavirinae, Betacoronavirus, Subgenus Sarbecovirus): Lessons of SARS-CoV Outbreak.]." Voprosy Virusologii, vol. 65, no. 1, 2020, pp. 6-15.
Lvov DK, Alkhovsky SV, Kolobukhina LV, et al. [Etiology of epidemic outbreaks COVID-19 on Wuhan, Hubei province, Chinese People Republic associated with 2019-nCoV (Nidovirales, Coronaviridae, Coronavirinae, Betacoronavirus, Subgenus Sarbecovirus): lessons of SARS-CoV outbreak.]. Vopr Virusol. 2020;65(1):6-15.
Lvov, D. K., Alkhovsky, S. V., Kolobukhina, L. V., & Burtseva, E. I. (2020). [Etiology of epidemic outbreaks COVID-19 on Wuhan, Hubei province, Chinese People Republic associated with 2019-nCoV (Nidovirales, Coronaviridae, Coronavirinae, Betacoronavirus, Subgenus Sarbecovirus): lessons of SARS-CoV outbreak.]. Voprosy Virusologii, 65(1), 6-15. https://doi.org/10.36233/0507-4088-2020-65-1-6-15
Lvov DK, et al. [Etiology of Epidemic Outbreaks COVID-19 On Wuhan, Hubei Province, Chinese People Republic Associated With 2019-nCoV (Nidovirales, Coronaviridae, Coronavirinae, Betacoronavirus, Subgenus Sarbecovirus): Lessons of SARS-CoV Outbreak.]. Vopr Virusol. 2020;65(1):6-15. PubMed PMID: 32496715.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Etiology of epidemic outbreaks COVID-19 on Wuhan, Hubei province, Chinese People Republic associated with 2019-nCoV (Nidovirales, Coronaviridae, Coronavirinae, Betacoronavirus, Subgenus Sarbecovirus): lessons of SARS-CoV outbreak.] AU - Lvov,D K, AU - Alkhovsky,S V, AU - Kolobukhina,L V, AU - Burtseva,E I, PY - 2020/01/20/received PY - 2020/01/29/accepted PY - 2020/6/5/entrez PY - 2020/6/5/pubmed PY - 2020/6/18/medline KW - 2019-nCoV KW - Betacoronavirus KW - COVID-19, bats KW - Coronaviridae KW - MERS-CoV KW - SARS-CoV KW - ecology KW - phylogenetic KW - review KW - sequencing SP - 6 EP - 15 JF - Voprosy virusologii JO - Vopr Virusol VL - 65 IS - 1 N2 - Results of analysis of phylogenetic, virological, epidemiological, ecological, clinical data of COVID-19 outbreaks in Wuhan, China (PRC) in comparison with SARS-2002 and MERS-2012 outbreaks allow to conclude: - the etiological agent of COVID-19 is coronavirus (2019-CoV), phylogenetically close to the SARS-CoV, isolated from human, and SARS-related viruses isolated from bats (SARS-related bat CoV viruses). These viruses belong to the Sarbecovirus subgenus, Betacoronavirus genus, Orthocoronavirinae subfamily, Coronaviridae family (Cornidovirinea: Nidovirales). COVID-19 is a variant of SARS-2002 and is different from MERS-2012 outbreak, which were caused by coronavirus belonged to the subgenus Merbecovirus of the same genus; - according to the results of phylogenetic analysis of 35 different betacoronaviruses, isolated from human and from wild animals in 2002-2019, the natural source of COVID-19 and SARS-CoV (2002) is bats of Rhinolophus genus (Rhinolophidae) and, probably, some species of other genera. An additional reservoir of the virus could be an intermediate animal species (snakes, civet, hedgehogs, badgers, etc.) that are infected by eating of infected bats. SARS-like coronaviruses circulated in bats in the interepidemic period (2003-2019); - seasonal coronaviruses (subgenus Duvinacovirus, Alphacoronavirus) are currently circulating (November 2019 - January 2020) in the European part of Russia, Urals, Siberia and the Far East of Russia, along with the influenza viruses A(H1N1)pdm09, A(H3N2), and В, as well as six other respiratory viruses (HPIV, HAdV, HRSV, HRV, HBoV, and HMPV). SN - 2411-2097 UR - https://www.unboundmedicine.com/medline/citation/32496715/[Etiology_of_epidemic_outbreaks_COVID_19_on_Wuhan_Hubei_province_Chinese_People_Republic_associated_with_2019_nCoV__Nidovirales_Coronaviridae_Coronavirinae_Betacoronavirus_Subgenus_Sarbecovirus_:_lessons_of_SARS_CoV_outbreak_] DB - PRIME DP - Unbound Medicine ER -