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Optical Coherence Tomography Angiography in Neurodegenerative Disorders.
J Clin Med. 2020 Jun 02; 9(6)JC

Abstract

Retinal microcirculation shares similar features with cerebral small blood vessels. Thus, the retina may be considered an accessible 'window' to detect the microvascular damage occurring in the setting of neurodegenerative disorders. Optical coherence tomography angiography (OCT-A) is a non-invasive imaging modality providing depth resolved images of blood flow in the retina, choroid, and optic nerve. In this review, we summarize the current literature on the application of OCT-A in glaucoma and central nervous system conditions such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis. Future directions aiming at evaluating whether OCT-A can be an additional biomarker for the early diagnosis and monitoring of neurodegenerative disorders are also discussed.

Authors+Show Affiliations

Ophthalmology Unit, S. Orsola-Malpighi University Hospital, University of Bologna, 40138 Bologna, Italy.University Eye Clinic, DINOGMI, Polyclinic Hospital San Martino IRCCS, 16132 Genoa, Italy.University Eye Clinic, DINOGMI, Polyclinic Hospital San Martino IRCCS, 16132 Genoa, Italy.Ophthalmology Unit, S. Orsola-Malpighi University Hospital, University of Bologna, 40138 Bologna, Italy.Ophthalmology Department, Fatebenefratelli and Ophthalmic Hospital, ASST-Fatebenefratelli-Sacco, 63631 Milan, Italy.Institute of Ophthalmology, University of Modena and Reggio Emilia, 41121 Modena, Italy.University Eye Clinic, DINOGMI, Polyclinic Hospital San Martino IRCCS, 16132 Genoa, Italy.Department of Ophthalmology, Hospital San Raffaele, University Vita Salute San Raffaele, 20132 Milan, Italy.Department of Ophthalmology, Hospital San Raffaele, University Vita Salute San Raffaele, 20132 Milan, Italy.Department of Surgical Sciences, Eye Clinic, University of Cagliari, 09124 Cagliari, Italy.Department of Ophthalmology, University Campus Bio-Medico of Rome, 00128 Rome, Italy.Domus Nova Hospital, 48121 Ravenna, Department of Ophthalmology, Ospedale dello Stato della Repubblica di San Marino, 47893 Città di San Marino, San Marino.Department of Ophthalmology, University "Magna Graecia", 88100 Catanzaro, Italy.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32498362

Citation

Pellegrini, Marco, et al. "Optical Coherence Tomography Angiography in Neurodegenerative Disorders." Journal of Clinical Medicine, vol. 9, no. 6, 2020.
Pellegrini M, Vagge A, Ferro Desideri LF, et al. Optical Coherence Tomography Angiography in Neurodegenerative Disorders. J Clin Med. 2020;9(6).
Pellegrini, M., Vagge, A., Ferro Desideri, L. F., Bernabei, F., Triolo, G., Mastropasqua, R., Del Noce, C. D., Borrelli, E., Sacconi, R., Iovino, C., Di Zazzo, A. D., Forlini, M., & Giannaccare, G. (2020). Optical Coherence Tomography Angiography in Neurodegenerative Disorders. Journal of Clinical Medicine, 9(6). https://doi.org/10.3390/jcm9061706
Pellegrini M, et al. Optical Coherence Tomography Angiography in Neurodegenerative Disorders. J Clin Med. 2020 Jun 2;9(6) PubMed PMID: 32498362.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Optical Coherence Tomography Angiography in Neurodegenerative Disorders. AU - Pellegrini,Marco, AU - Vagge,Aldo, AU - Ferro Desideri,Lorenzo Ferro, AU - Bernabei,Federico, AU - Triolo,Giacinto, AU - Mastropasqua,Rodolfo, AU - Del Noce,Chiara Del, AU - Borrelli,Enrico, AU - Sacconi,Riccardo, AU - Iovino,Claudio, AU - Di Zazzo,Antonio Di, AU - Forlini,Matteo, AU - Giannaccare,Giuseppe, Y1 - 2020/06/02/ PY - 2020/04/27/received PY - 2020/05/29/accepted PY - 2020/6/6/entrez PY - 2020/6/6/pubmed PY - 2020/6/6/medline KW - Alzheimer’s disease KW - Parkinson’s disease KW - glaucoma KW - multiple sclerosis KW - neurodegenerative disorders KW - optical coherence tomography angiography JF - Journal of clinical medicine JO - J Clin Med VL - 9 IS - 6 N2 - Retinal microcirculation shares similar features with cerebral small blood vessels. Thus, the retina may be considered an accessible 'window' to detect the microvascular damage occurring in the setting of neurodegenerative disorders. Optical coherence tomography angiography (OCT-A) is a non-invasive imaging modality providing depth resolved images of blood flow in the retina, choroid, and optic nerve. In this review, we summarize the current literature on the application of OCT-A in glaucoma and central nervous system conditions such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis. Future directions aiming at evaluating whether OCT-A can be an additional biomarker for the early diagnosis and monitoring of neurodegenerative disorders are also discussed. SN - 2077-0383 UR - https://www.unboundmedicine.com/medline/citation/32498362/Optical_Coherence_Tomography_Angiography_in_Neurodegenerative_Disorders_ L2 - https://www.mdpi.com/resolver?pii=jcm9061706 DB - PRIME DP - Unbound Medicine ER -
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