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Olfactory and gustatory dysfunctions in 100 patients hospitalized for COVID-19: sex differences and recovery time in real-life.
Eur Arch Otorhinolaryngol. 2020 Dec; 277(12):3519-3523.EA

Abstract

PURPOSE

COVID-19 displays a variety of clinical manifestations; in pauci-symptomatic patients olfactory (OD) and gustatory dysfunctions (GD) may represent the first or only symptom. This topic is currently arousing great interest, and a growing number of papers are being published. Aim of this study is to investigate the timing of recovery from OD and GD in a real-life population hospitalized for COVID-19.

METHODS

We followed up by a phone interview the first 100 patients discharged a month earlier from three Italian non-intensive care wards.

RESULTS

All 100 patients were Caucasian, mean age was 65 years, 60% were males. Forty-two patients (mean age 63 years) experienced subjective chemosensory dysfunctions (29 OD and 41 GD): the male/female ratio was 2:1; 83% reported a complete or near complete recovery at follow-up. The recovery rate was not significantly different between males and females. The mean duration of OD and GD was 18 and 16 days, respectively. The mean recovery time from OD or GD resulted significantly longer for females than for males (26 vs 14 days, P = 0.009). Among the 42 symptomatic, the mean age of males was significantly higher than that of females (66 vs 57 years, P = 0.04), while the opposite was observed in the 58 asymptomatic patients (60 vs 73 years, P = 0.0018).

CONCLUSIONS

Recovery from OD or GD was rapid, occurring within 4 weeks in most patients. Chemosensory dysfunctions in women was less frequent, but longer lasting. The value of our study is its focus on a population of hospitalized patients significantly older than those previously described, and the additional data on gender differences.

Authors+Show Affiliations

Internal Medicine Unit, Santa Maria Annunziata Hospital, Florence, Italy. simonemeini2@gmail.com.Infectious Disease Unit, Santa Maria Annunziata Hospital, Florence, Italy.Otolaryngology-Head and Neck Surgery Unit, Santa Maria Nuova Hospital, Florence, Italy.Medical Department-Hospital Area, AUSL Toscana Nord-Ovest, Pisa, Italy.Internal Medicine Unit, Nuovo San Giovanni Di Dio Hospital, Florence, Italy.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32500326

Citation

Meini, Simone, et al. "Olfactory and Gustatory Dysfunctions in 100 Patients Hospitalized for COVID-19: Sex Differences and Recovery Time in Real-life." European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated With the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, vol. 277, no. 12, 2020, pp. 3519-3523.
Meini S, Suardi LR, Busoni M, et al. Olfactory and gustatory dysfunctions in 100 patients hospitalized for COVID-19: sex differences and recovery time in real-life. Eur Arch Otorhinolaryngol. 2020;277(12):3519-3523.
Meini, S., Suardi, L. R., Busoni, M., Roberts, A. T., & Fortini, A. (2020). Olfactory and gustatory dysfunctions in 100 patients hospitalized for COVID-19: sex differences and recovery time in real-life. European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated With the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 277(12), 3519-3523. https://doi.org/10.1007/s00405-020-06102-8
Meini S, et al. Olfactory and Gustatory Dysfunctions in 100 Patients Hospitalized for COVID-19: Sex Differences and Recovery Time in Real-life. Eur Arch Otorhinolaryngol. 2020;277(12):3519-3523. PubMed PMID: 32500326.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Olfactory and gustatory dysfunctions in 100 patients hospitalized for COVID-19: sex differences and recovery time in real-life. AU - Meini,Simone, AU - Suardi,Lorenzo Roberto, AU - Busoni,Michele, AU - Roberts,Anna Teresa, AU - Fortini,Alberto, Y1 - 2020/06/04/ PY - 2020/04/25/received PY - 2020/05/29/accepted PY - 2020/6/6/pubmed PY - 2020/12/1/medline PY - 2020/6/6/entrez KW - Age KW - Ageusia KW - Anosmia KW - COVID-19 KW - Recovery KW - Sex SP - 3519 EP - 3523 JF - European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery JO - Eur Arch Otorhinolaryngol VL - 277 IS - 12 N2 - PURPOSE: COVID-19 displays a variety of clinical manifestations; in pauci-symptomatic patients olfactory (OD) and gustatory dysfunctions (GD) may represent the first or only symptom. This topic is currently arousing great interest, and a growing number of papers are being published. Aim of this study is to investigate the timing of recovery from OD and GD in a real-life population hospitalized for COVID-19. METHODS: We followed up by a phone interview the first 100 patients discharged a month earlier from three Italian non-intensive care wards. RESULTS: All 100 patients were Caucasian, mean age was 65 years, 60% were males. Forty-two patients (mean age 63 years) experienced subjective chemosensory dysfunctions (29 OD and 41 GD): the male/female ratio was 2:1; 83% reported a complete or near complete recovery at follow-up. The recovery rate was not significantly different between males and females. The mean duration of OD and GD was 18 and 16 days, respectively. The mean recovery time from OD or GD resulted significantly longer for females than for males (26 vs 14 days, P = 0.009). Among the 42 symptomatic, the mean age of males was significantly higher than that of females (66 vs 57 years, P = 0.04), while the opposite was observed in the 58 asymptomatic patients (60 vs 73 years, P = 0.0018). CONCLUSIONS: Recovery from OD or GD was rapid, occurring within 4 weeks in most patients. Chemosensory dysfunctions in women was less frequent, but longer lasting. The value of our study is its focus on a population of hospitalized patients significantly older than those previously described, and the additional data on gender differences. SN - 1434-4726 UR - https://www.unboundmedicine.com/medline/citation/32500326/Olfactory_and_gustatory_dysfunctions_in_100_patients_hospitalized_for_COVID_19:_sex_differences_and_recovery_time_in_real_life_ L2 - https://dx.doi.org/10.1007/s00405-020-06102-8 DB - PRIME DP - Unbound Medicine ER -