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Comparison of confirmed COVID-19 with SARS and MERS cases - Clinical characteristics, laboratory findings, radiographic signs and outcomes: A systematic review and meta-analysis.
Rev Med Virol. 2020 07; 30(4):e2112.RM

Abstract

INTRODUCTION

Within this large-scale study, we compared clinical symptoms, laboratory findings, radiographic signs, and outcomes of COVID-19, SARS, and MERS to find unique features.

METHOD

We searched all relevant literature published up to February 28, 2020. Depending on the heterogeneity test, we used either random or fixed-effect models to analyze the appropriateness of the pooled results. Study has been registered in the PROSPERO database (ID 176106).

RESULT

Overall 114 articles included in this study; 52 251 COVID-19 confirmed patients (20 studies), 10 037 SARS (51 studies), and 8139 MERS patients (43 studies) were included. The most common symptom was fever; COVID-19 (85.6%, P < .001), SARS (96%, P < .001), and MERS (74%, P < .001), respectively. Analysis showed that 84% of Covid-19 patients, 86% of SARS patients, and 74.7% of MERS patients had an abnormal chest X-ray. The mortality rate in COVID-19 (5.6%, P < .001) was lower than SARS (13%, P < .001) and MERS (35%, P < .001) between all confirmed patients.

CONCLUSIONS

At the time of submission, the mortality rate in COVID-19 confirmed cases is lower than in SARS- and MERS-infected patients. Clinical outcomes and findings would be biased by reporting only confirmed cases, and this should be considered when interpreting the data.

Links

Publisher Full Text
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Authors+Show Affiliations

Pormohammad A
Department of Biological Sciences, University of Calgary, Calgary, AB, Canada.
Ghorbani S
Department of Virology, Faculty of Medicine, Iran University of Medical Science, Tehran, Iran.
Khatami A
Department of Virology, Faculty of Medicine, Iran University of Medical Science, Tehran, Iran.
Farzi R
Department of Virology, Faculty of Medicine, Shiraz University of Medical Science, Shiraz, Iran.
Baradaran B
Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Department of Immunology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Turner DL
Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Turner RJ
Department of Biological Sciences, University of Calgary, Calgary, Alberta, Canada.
Bahr NC
Division of Infectious Diseases, Department of Medicine, University of Kansas, Kansas City, Kansas, USA.
Idrovo JP
Division of GI, Trauma and Endocrine Surgery, Department of Surgery, University of Colorado, Denver, Colorado, USA.

MeSH

BetacoronavirusBlood Cell CountCOVID-19ChinaCoronavirus InfectionsCoughDyspneaFemaleFeverHospitalizationHumansLungMaleMiddle East Respiratory Syndrome CoronavirusPandemicsPneumonia, ViralRisk FactorsSARS-CoV-2Severe Acute Respiratory SyndromeTravel

Pub Type(s)

Journal Article
Meta-Analysis
Systematic Review

Language

eng

PubMed ID

32502331

Citation

Pormohammad, Ali, et al. "Comparison of Confirmed COVID-19 With SARS and MERS Cases - Clinical Characteristics, Laboratory Findings, Radiographic Signs and Outcomes: a Systematic Review and Meta-analysis." Reviews in Medical Virology, vol. 30, no. 4, 2020, pp. e2112.
Pormohammad A, Ghorbani S, Khatami A, et al. Comparison of confirmed COVID-19 with SARS and MERS cases - Clinical characteristics, laboratory findings, radiographic signs and outcomes: A systematic review and meta-analysis. Rev Med Virol. 2020;30(4):e2112.
Pormohammad, A., Ghorbani, S., Khatami, A., Farzi, R., Baradaran, B., Turner, D. L., Turner, R. J., Bahr, N. C., & Idrovo, J. P. (2020). Comparison of confirmed COVID-19 with SARS and MERS cases - Clinical characteristics, laboratory findings, radiographic signs and outcomes: A systematic review and meta-analysis. Reviews in Medical Virology, 30(4), e2112. https://doi.org/10.1002/rmv.2112
Pormohammad A, et al. Comparison of Confirmed COVID-19 With SARS and MERS Cases - Clinical Characteristics, Laboratory Findings, Radiographic Signs and Outcomes: a Systematic Review and Meta-analysis. Rev Med Virol. 2020;30(4):e2112. PubMed PMID: 32502331.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of confirmed COVID-19 with SARS and MERS cases - Clinical characteristics, laboratory findings, radiographic signs and outcomes: A systematic review and meta-analysis. AU - Pormohammad,Ali, AU - Ghorbani,Saied, AU - Khatami,Alireza, AU - Farzi,Rana, AU - Baradaran,Behzad, AU - Turner,Diana L, AU - Turner,Raymond J, AU - Bahr,Nathan C, AU - Idrovo,Juan-Pablo, Y1 - 2020/06/05/ PY - 2020/04/08/received PY - 2020/04/21/revised PY - 2020/04/22/accepted PY - 2020/6/6/pubmed PY - 2020/7/21/medline PY - 2020/6/6/entrez KW - COVID-19 KW - Middle East respiratory syndrome coronavirus KW - SARS virus KW - coronavirus KW - meta-analysis KW - severe acute respiratory syndrome SP - e2112 EP - e2112 JF - Reviews in medical virology JO - Rev Med Virol VL - 30 IS - 4 N2 - INTRODUCTION: Within this large-scale study, we compared clinical symptoms, laboratory findings, radiographic signs, and outcomes of COVID-19, SARS, and MERS to find unique features. METHOD: We searched all relevant literature published up to February 28, 2020. Depending on the heterogeneity test, we used either random or fixed-effect models to analyze the appropriateness of the pooled results. Study has been registered in the PROSPERO database (ID 176106). RESULT: Overall 114 articles included in this study; 52 251 COVID-19 confirmed patients (20 studies), 10 037 SARS (51 studies), and 8139 MERS patients (43 studies) were included. The most common symptom was fever; COVID-19 (85.6%, P < .001), SARS (96%, P < .001), and MERS (74%, P < .001), respectively. Analysis showed that 84% of Covid-19 patients, 86% of SARS patients, and 74.7% of MERS patients had an abnormal chest X-ray. The mortality rate in COVID-19 (5.6%, P < .001) was lower than SARS (13%, P < .001) and MERS (35%, P < .001) between all confirmed patients. CONCLUSIONS: At the time of submission, the mortality rate in COVID-19 confirmed cases is lower than in SARS- and MERS-infected patients. Clinical outcomes and findings would be biased by reporting only confirmed cases, and this should be considered when interpreting the data. SN - 1099-1654 UR - https://www.unboundmedicine.com/medline/citation/32502331/Comparison_of_confirmed_COVID_19_with_SARS_and_MERS_cases___Clinical_characteristics_laboratory_findings_radiographic_signs_and_outcomes:_A_systematic_review_and_meta_analysis_ L2 - https://doi.org/10.1002/rmv.2112 DB - PRIME DP - Unbound Medicine ER -