Tags

Type your tag names separated by a space and hit enter

Does vitamin D deficiency increase the severity of COVID-19?
Clin Med (Lond). 2020 07; 20(4):e107-e108.CM

Abstract

The severity of coronavirus 2019 infection (COVID-19) is determined by the presence of pneumonia, severe acute respiratory distress syndrome (SARS-CoV-2), myocarditis, microvascular thrombosis and/or cytokine storms, all of which involve underlying inflammation. A principal defence against uncontrolled inflammation, and against viral infection in general, is provided by T regulatory lymphocytes (Tregs). Treg levels have been reported to be low in many COVID-19 patients and can be increased by vitamin D supplementation. Low vitamin D levels have been associated with an increase in inflammatory cytokines and a significantly increased risk of pneumonia and viral upper respiratory tract infections. Vitamin D deficiency is associated with an increase in thrombotic episodes, which are frequently observed in COVID-19. Vitamin D deficiency has been found to occur more frequently in patients with obesity and diabetes. These conditions are reported to carry a higher mortality in COVID-19. If vitamin D does in fact reduce the severity of COVID-19 in regard to pneumonia/ARDS, inflammation, inflammatory cytokines and thrombosis, it is our opinion that supplements would offer a relatively easy option to decrease the impact of the pandemic.

Authors+Show Affiliations

Cardiovascular Division, University of Minnesota, Minneapolis, USA weirx002@umn.edu.Cardiovascular Division, University of Minnesota, Minneapolis, USA.Division of Pulmonary, Allergy, Critical Care and Sleep, University of Minnesota, Minneapolis, USA.Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, USA.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32503801

Citation

Weir, E Kenneth, et al. "Does Vitamin D Deficiency Increase the Severity of COVID-19?" Clinical Medicine (London, England), vol. 20, no. 4, 2020, pp. e107-e108.
Weir EK, Thenappan T, Bhargava M, et al. Does vitamin D deficiency increase the severity of COVID-19? Clin Med (Lond). 2020;20(4):e107-e108.
Weir, E. K., Thenappan, T., Bhargava, M., & Chen, Y. (2020). Does vitamin D deficiency increase the severity of COVID-19? Clinical Medicine (London, England), 20(4), e107-e108. https://doi.org/10.7861/clinmed.2020-0301
Weir EK, et al. Does Vitamin D Deficiency Increase the Severity of COVID-19. Clin Med (Lond). 2020;20(4):e107-e108. PubMed PMID: 32503801.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Does vitamin D deficiency increase the severity of COVID-19? AU - Weir,E Kenneth, AU - Thenappan,Thenappan, AU - Bhargava,Maneesh, AU - Chen,Yingjie, Y1 - 2020/06/05/ PY - 2020/6/7/pubmed PY - 2020/8/4/medline PY - 2020/6/7/entrez KW - COVID 19 KW - Treg KW - Vitamin D KW - coronavirus KW - inflammation SP - e107 EP - e108 JF - Clinical medicine (London, England) JO - Clin Med (Lond) VL - 20 IS - 4 N2 - The severity of coronavirus 2019 infection (COVID-19) is determined by the presence of pneumonia, severe acute respiratory distress syndrome (SARS-CoV-2), myocarditis, microvascular thrombosis and/or cytokine storms, all of which involve underlying inflammation. A principal defence against uncontrolled inflammation, and against viral infection in general, is provided by T regulatory lymphocytes (Tregs). Treg levels have been reported to be low in many COVID-19 patients and can be increased by vitamin D supplementation. Low vitamin D levels have been associated with an increase in inflammatory cytokines and a significantly increased risk of pneumonia and viral upper respiratory tract infections. Vitamin D deficiency is associated with an increase in thrombotic episodes, which are frequently observed in COVID-19. Vitamin D deficiency has been found to occur more frequently in patients with obesity and diabetes. These conditions are reported to carry a higher mortality in COVID-19. If vitamin D does in fact reduce the severity of COVID-19 in regard to pneumonia/ARDS, inflammation, inflammatory cytokines and thrombosis, it is our opinion that supplements would offer a relatively easy option to decrease the impact of the pandemic. SN - 1473-4893 UR - https://www.unboundmedicine.com/medline/citation/32503801/Does_vitamin_D_deficiency_increase_the_severity_of_COVID_19 DB - PRIME DP - Unbound Medicine ER -