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Role of Interleukin-6 in Lung Complications in Patients With COVID-19: Therapeutic Implications.
In Vivo. 2020 Jun; 34(3 Suppl):1589-1592.V

Abstract

COVID-19 is viral respiratory infection with frequently fatal lung complications in the elderly or in people with serious comorbidities. Lung destruction appears to be associated with a cytokine storm related to an increased level of interleukin-6 (IL6). Therapeutic targeting of the interleukin-6 signaling pathway can attenuate such a cytokine storm and can be beneficial for patients with COVID-19 in danger of pulmonary failure. This article demonstrates the importance of IL6 in progression of disease and the possibility of inhibition of IL6 signaling in COVID-19 therapy.

Authors+Show Affiliations

Institute of Anatomy, First Faculty of Medicine, Charles University, Prague, Czech Republic jan.brabek@natur.cuni.cz karel.smetana@lf1.cuni.cz. BIOCEV, Vestec, Czech Republic.BIOCEV, Vestec, Czech Republic jan.brabek@natur.cuni.cz karel.smetana@lf1.cuni.cz. Department of Cell Biology, Faculty of Sciences, Charles University, Prague, Czech Republic.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32503815

Citation

Smetana, Karel, and Jan Brábek. "Role of Interleukin-6 in Lung Complications in Patients With COVID-19: Therapeutic Implications." In Vivo (Athens, Greece), vol. 34, no. 3 Suppl, 2020, pp. 1589-1592.
Smetana K, Brábek J. Role of Interleukin-6 in Lung Complications in Patients With COVID-19: Therapeutic Implications. In Vivo. 2020;34(3 Suppl):1589-1592.
Smetana, K., & Brábek, J. (2020). Role of Interleukin-6 in Lung Complications in Patients With COVID-19: Therapeutic Implications. In Vivo (Athens, Greece), 34(3 Suppl), 1589-1592. https://doi.org/10.21873/invivo.11947
Smetana K, Brábek J. Role of Interleukin-6 in Lung Complications in Patients With COVID-19: Therapeutic Implications. In Vivo. 2020;34(3 Suppl):1589-1592. PubMed PMID: 32503815.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role of Interleukin-6 in Lung Complications in Patients With COVID-19: Therapeutic Implications. AU - Smetana,Karel,Jr AU - Brábek,Jan, PY - 2020/04/15/received PY - 2020/04/16/revised PY - 2020/04/23/accepted PY - 2020/6/7/entrez PY - 2020/6/7/pubmed PY - 2020/6/23/medline KW - COVID-19 therapy KW - IL6 KW - SARS-CoV-2 KW - cytokine storm KW - lung failure KW - review SP - 1589 EP - 1592 JF - In vivo (Athens, Greece) JO - In Vivo VL - 34 IS - 3 Suppl N2 - COVID-19 is viral respiratory infection with frequently fatal lung complications in the elderly or in people with serious comorbidities. Lung destruction appears to be associated with a cytokine storm related to an increased level of interleukin-6 (IL6). Therapeutic targeting of the interleukin-6 signaling pathway can attenuate such a cytokine storm and can be beneficial for patients with COVID-19 in danger of pulmonary failure. This article demonstrates the importance of IL6 in progression of disease and the possibility of inhibition of IL6 signaling in COVID-19 therapy. SN - 1791-7549 UR - https://www.unboundmedicine.com/medline/citation/32503815/Role_of_Interleukin_6_in_Lung_Complications_in_Patients_With_COVID_19:_Therapeutic_Implications_ L2 - http://iv.iiarjournals.org/cgi/pmidlookup?view=long&pmid=32503815 DB - PRIME DP - Unbound Medicine ER -