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Gross and histopathological pulmonary findings in a COVID-19 associated death during self-isolation.
Int J Legal Med. 2020 Jul; 134(4):1285-1290.IJ

Abstract

Forensic investigations generally contain extensive morphological examinations to accurately diagnose the cause of death. Thus, the appearance of a new disease often creates emerging challenges in morphological examinations due to the lack of available data from autopsy- or biopsy-based research. Since late December 2019, an outbreak of a novel seventh coronavirus disease has been reported in China caused by "severe acute respiratory syndrome coronavirus 2" (SARS-CoV-2). On March 11, 2020, the new clinical condition COVID-19 (Corona-Virus-Disease-19) was declared a pandemic by the World Health Organization (WHO). Patients with COVID-19 mainly have a mild disease course, but severe disease onset might result in death due to proceeded lung injury with massive alveolar damage and progressive respiratory failure. However, the detailed mechanisms that cause organ injury still remain unclear. We investigated the morphological findings of a COVID-19 patient who died during self-isolation. Pathologic examination revealed massive bilateral alveolar damage, indicating early-phase "acute respiratory distress syndrome" (ARDS). This case emphasizes the possibility of a rapid severe disease onset in previously mild clinical condition and highlights the necessity of a complete autopsy to gain a better understanding of the pathophysiological changes in SARS-CoV-2 infections.

Authors+Show Affiliations

Cantonal Hospital St. Gallen, Institute of Legal Medicine, Rorschacherstrasse 95, CH-9007, St. Gallen, Switzerland.Cantonal Hospital St. Gallen, Institute of Legal Medicine, Rorschacherstrasse 95, CH-9007, St. Gallen, Switzerland. roland.hausmann@kssg.ch.

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

32504146

Citation

Suess, Christine, and Roland Hausmann. "Gross and Histopathological Pulmonary Findings in a COVID-19 Associated Death During Self-isolation." International Journal of Legal Medicine, vol. 134, no. 4, 2020, pp. 1285-1290.
Suess C, Hausmann R. Gross and histopathological pulmonary findings in a COVID-19 associated death during self-isolation. Int J Legal Med. 2020;134(4):1285-1290.
Suess, C., & Hausmann, R. (2020). Gross and histopathological pulmonary findings in a COVID-19 associated death during self-isolation. International Journal of Legal Medicine, 134(4), 1285-1290. https://doi.org/10.1007/s00414-020-02319-8
Suess C, Hausmann R. Gross and Histopathological Pulmonary Findings in a COVID-19 Associated Death During Self-isolation. Int J Legal Med. 2020;134(4):1285-1290. PubMed PMID: 32504146.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gross and histopathological pulmonary findings in a COVID-19 associated death during self-isolation. AU - Suess,Christine, AU - Hausmann,Roland, Y1 - 2020/06/05/ PY - 2020/04/23/received PY - 2020/05/19/accepted PY - 2020/6/7/pubmed PY - 2020/7/1/medline PY - 2020/6/7/entrez KW - COVID-19 KW - Coronavirus KW - Diffuse alveolar damage KW - Forensic autopsy SP - 1285 EP - 1290 JF - International journal of legal medicine JO - Int J Legal Med VL - 134 IS - 4 N2 - Forensic investigations generally contain extensive morphological examinations to accurately diagnose the cause of death. Thus, the appearance of a new disease often creates emerging challenges in morphological examinations due to the lack of available data from autopsy- or biopsy-based research. Since late December 2019, an outbreak of a novel seventh coronavirus disease has been reported in China caused by "severe acute respiratory syndrome coronavirus 2" (SARS-CoV-2). On March 11, 2020, the new clinical condition COVID-19 (Corona-Virus-Disease-19) was declared a pandemic by the World Health Organization (WHO). Patients with COVID-19 mainly have a mild disease course, but severe disease onset might result in death due to proceeded lung injury with massive alveolar damage and progressive respiratory failure. However, the detailed mechanisms that cause organ injury still remain unclear. We investigated the morphological findings of a COVID-19 patient who died during self-isolation. Pathologic examination revealed massive bilateral alveolar damage, indicating early-phase "acute respiratory distress syndrome" (ARDS). This case emphasizes the possibility of a rapid severe disease onset in previously mild clinical condition and highlights the necessity of a complete autopsy to gain a better understanding of the pathophysiological changes in SARS-CoV-2 infections. SN - 1437-1596 UR - https://www.unboundmedicine.com/medline/citation/32504146/Gross_and_histopathological_pulmonary_findings_in_a_COVID_19_associated_death_during_self_isolation_ DB - PRIME DP - Unbound Medicine ER -