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Unpredicted late-, new-onset thrombocytopenia and hypofibrinogenemia in Fab antivenom-treated rattlesnake envenomation.
Toxicon. 2020 Sep; 184:55-56.T

Abstract

The use of Fab antivenom (Crotalidae Polyvalent Immune Fab (Ovine) (CroFab); Boston Scientific) against North American Crotalidae envenomation is associated with the development of late- (≥4 days post-envenomation), new-onset of hematological abnormalities. Although attempts have been made to identify predictive indicators during the acute phase of an envenomation, of patients who are not at-risk of late-, new-onset of hematological abnormalities, there has been at least one prior report of a patient who developed thrombocytopenia that was unpredicted by current indicators. We add three cases of unpredicted, late-, new-onset of hematological abnormalities in patients with Fab-treated rattlesnake bite.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Seifert SA
University of New Mexico Health Sciences Center, Department of Emergency Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM, USA; New Mexico Poison Center, University of New Mexico Health Sciences Center, Albuquerque, NM, USA. Electronic address: sseifert@salud.unm.edu.
Mascarenas DN
Division of Pediatric Emergency Medicine, Department of Emergency Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
Fullerton L
Division of Pediatric Emergency Medicine, Department of Emergency Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
Warrick BJ
University of New Mexico Health Sciences Center, Department of Emergency Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM, USA; New Mexico Poison Center, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
Smolinske SC
New Mexico Poison Center, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.

MeSH

AfibrinogenemiaAnimalsAntiveninsCrotalid VenomsCrotalusHumansImmunoglobulin Fab FragmentsSheepSnake BitesThrombocytopenia

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32505639

Citation

Seifert, S A., et al. "Unpredicted Late-, New-onset Thrombocytopenia and Hypofibrinogenemia in Fab Antivenom-treated Rattlesnake Envenomation." Toxicon : Official Journal of the International Society On Toxinology, vol. 184, 2020, pp. 55-56.
Seifert SA, Mascarenas DN, Fullerton L, et al. Unpredicted late-, new-onset thrombocytopenia and hypofibrinogenemia in Fab antivenom-treated rattlesnake envenomation. Toxicon. 2020;184:55-56.
Seifert, S. A., Mascarenas, D. N., Fullerton, L., Warrick, B. J., & Smolinske, S. C. (2020). Unpredicted late-, new-onset thrombocytopenia and hypofibrinogenemia in Fab antivenom-treated rattlesnake envenomation. Toxicon : Official Journal of the International Society On Toxinology, 184, 55-56. https://doi.org/10.1016/j.toxicon.2020.05.026
Seifert SA, et al. Unpredicted Late-, New-onset Thrombocytopenia and Hypofibrinogenemia in Fab Antivenom-treated Rattlesnake Envenomation. Toxicon. 2020;184:55-56. PubMed PMID: 32505639.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Unpredicted late-, new-onset thrombocytopenia and hypofibrinogenemia in Fab antivenom-treated rattlesnake envenomation. AU - Seifert,S A, AU - Mascarenas,D N, AU - Fullerton,L, AU - Warrick,B J, AU - Smolinske,S C, Y1 - 2020/06/04/ PY - 2020/04/07/received PY - 2020/05/28/revised PY - 2020/05/31/accepted PY - 2020/6/9/pubmed PY - 2020/8/28/medline PY - 2020/6/8/entrez KW - Antivenom KW - Envenomation KW - Fab KW - Fibrinogen KW - Platelets KW - Rattlesnake KW - Recurrence SP - 55 EP - 56 JF - Toxicon : official journal of the International Society on Toxinology JO - Toxicon VL - 184 N2 - The use of Fab antivenom (Crotalidae Polyvalent Immune Fab (Ovine) (CroFab); Boston Scientific) against North American Crotalidae envenomation is associated with the development of late- (≥4 days post-envenomation), new-onset of hematological abnormalities. Although attempts have been made to identify predictive indicators during the acute phase of an envenomation, of patients who are not at-risk of late-, new-onset of hematological abnormalities, there has been at least one prior report of a patient who developed thrombocytopenia that was unpredicted by current indicators. We add three cases of unpredicted, late-, new-onset of hematological abnormalities in patients with Fab-treated rattlesnake bite. SN - 1879-3150 UR - https://www.unboundmedicine.com/medline/citation/32505639/Unpredicted_late__new_onset_thrombocytopenia_and_hypofibrinogenemia_in_Fab_antivenom_treated_rattlesnake_envenomation_ DB - PRIME DP - Unbound Medicine ER -