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COVID-19: A Global Threat to the Nervous System.
Ann Neurol. 2020 07; 88(1):1-11.AN

Abstract

In less than 6 months, the severe acute respiratory syndrome-coronavirus type 2 (SARS-CoV-2) has spread worldwide infecting nearly 6 million people and killing over 350,000. Initially thought to be restricted to the respiratory system, we now understand that coronavirus disease 2019 (COVID-19) also involves multiple other organs, including the central and peripheral nervous system. The number of recognized neurologic manifestations of SARS-CoV-2 infection is rapidly accumulating. These may result from a variety of mechanisms, including virus-induced hyperinflammatory and hypercoagulable states, direct virus infection of the central nervous system (CNS), and postinfectious immune mediated processes. Example of COVID-19 CNS disease include encephalopathy, encephalitis, acute disseminated encephalomyelitis, meningitis, ischemic and hemorrhagic stroke, venous sinus thrombosis, and endothelialitis. In the peripheral nervous system, COVID-19 is associated with dysfunction of smell and taste, muscle injury, the Guillain-Barre syndrome, and its variants. Due to its worldwide distribution and multifactorial pathogenic mechanisms, COVID-19 poses a global threat to the entire nervous system. Although our understanding of SARS-CoV-2 neuropathogenesis is still incomplete and our knowledge is evolving rapidly, we hope that this review will provide a useful framework and help neurologists in understanding the many neurologic facets of COVID-19. ANN NEUROL 2020;88:1-11 ANN NEUROL 2020;88:1-11.

Authors+Show Affiliations

Davee Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.Department of Neurology, Medicine, and Immunology-Microbiology, University of Colorado School of Medicine, Aurora, CO, USA.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32506549

Citation

Koralnik, Igor J., and Kenneth L. Tyler. "COVID-19: a Global Threat to the Nervous System." Annals of Neurology, vol. 88, no. 1, 2020, pp. 1-11.
Koralnik IJ, Tyler KL. COVID-19: A Global Threat to the Nervous System. Ann Neurol. 2020;88(1):1-11.
Koralnik, I. J., & Tyler, K. L. (2020). COVID-19: A Global Threat to the Nervous System. Annals of Neurology, 88(1), 1-11. https://doi.org/10.1002/ana.25807
Koralnik IJ, Tyler KL. COVID-19: a Global Threat to the Nervous System. Ann Neurol. 2020;88(1):1-11. PubMed PMID: 32506549.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - COVID-19: A Global Threat to the Nervous System. AU - Koralnik,Igor J, AU - Tyler,Kenneth L, PY - 2020/05/19/received PY - 2020/05/29/revised PY - 2020/06/01/accepted PY - 2020/6/9/pubmed PY - 2020/7/3/medline PY - 2020/6/8/entrez SP - 1 EP - 11 JF - Annals of neurology JO - Ann Neurol VL - 88 IS - 1 N2 - In less than 6 months, the severe acute respiratory syndrome-coronavirus type 2 (SARS-CoV-2) has spread worldwide infecting nearly 6 million people and killing over 350,000. Initially thought to be restricted to the respiratory system, we now understand that coronavirus disease 2019 (COVID-19) also involves multiple other organs, including the central and peripheral nervous system. The number of recognized neurologic manifestations of SARS-CoV-2 infection is rapidly accumulating. These may result from a variety of mechanisms, including virus-induced hyperinflammatory and hypercoagulable states, direct virus infection of the central nervous system (CNS), and postinfectious immune mediated processes. Example of COVID-19 CNS disease include encephalopathy, encephalitis, acute disseminated encephalomyelitis, meningitis, ischemic and hemorrhagic stroke, venous sinus thrombosis, and endothelialitis. In the peripheral nervous system, COVID-19 is associated with dysfunction of smell and taste, muscle injury, the Guillain-Barre syndrome, and its variants. Due to its worldwide distribution and multifactorial pathogenic mechanisms, COVID-19 poses a global threat to the entire nervous system. Although our understanding of SARS-CoV-2 neuropathogenesis is still incomplete and our knowledge is evolving rapidly, we hope that this review will provide a useful framework and help neurologists in understanding the many neurologic facets of COVID-19. ANN NEUROL 2020;88:1-11 ANN NEUROL 2020;88:1-11. SN - 1531-8249 UR - https://www.unboundmedicine.com/medline/citation/32506549/COVID_19:_A_Global_Threat_to_the_Nervous_System_ L2 - https://doi.org/10.1002/ana.25807 DB - PRIME DP - Unbound Medicine ER -