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Antiparasitic effects of Zataria multiflora essential oil nano-emulsion on larval stages of Echinococcus granulosus.
J Parasit Dis. 2020 Jun; 44(2):429-435.JP

Abstract

Various protoscolicidal agents are indicated for the prevention of recurrence of cystic echinococcosis caused by the larval stage of Echinococcus granulosus; however, most of these chemicals have adverse side effects. This study evaluated the effects of Zataria multiflora essential oil (ZEO) nano-emulsion and emulsion at the concentrations of 1, 2, 5, 10, 15, and 20 µl/ml on E. granulosus protoscoleces. Albendazole (5 mg/ml), normal saline, and nano-emulsion without ZEO served as control groups. Optimal concentrations of ZEO nano-emulsion and emulsion on the microcysts were also investigated. ZEO emulsion at a concentration of 20 µl/ml for the duration of 15 min and nano-emulsion for the duration of 10 min resulted in the death of 100% of the protoscoleces. Additionally, densely packed aggregates were formed inside the microcysts treated with ZEO nano-emulsion and emulsion at a concentration of 20 µl/ml after 40 min, but the complete destruction of laminated layers did not occur. The results indicate that ZEO nano-emulsions have a higher protoscolicidal effect than its emulsion, but these two compounds had similar effects on microcysts.

Authors+Show Affiliations

Department of Parasitology and Mycology, School of Medicine, Zanjan University of Medical Sciences (ZUMS), Mahdavi Blvd., Shahrak Karmandan, P.O. Box 45139-56111, Zanjan, Iran.Department of Parasitology and Mycology, School of Medicine, Zanjan University of Medical Sciences (ZUMS), Mahdavi Blvd., Shahrak Karmandan, P.O. Box 45139-56111, Zanjan, Iran.School of Pharmacy, Zanjan University of Medical Sciences (ZUMS), Zanjan, Iran.Department of Parasitology and Mycology, School of Medicine, Zanjan University of Medical Sciences (ZUMS), Mahdavi Blvd., Shahrak Karmandan, P.O. Box 45139-56111, Zanjan, Iran.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32508418

Citation

Karimi Yazdi, Monire, et al. "Antiparasitic Effects of Zataria Multiflora Essential Oil Nano-emulsion On Larval Stages of Echinococcus Granulosus." Journal of Parasitic Diseases : Official Organ of the Indian Society for Parasitology, vol. 44, no. 2, 2020, pp. 429-435.
Karimi Yazdi M, Haniloo A, Ghaffari A, et al. Antiparasitic effects of Zataria multiflora essential oil nano-emulsion on larval stages of Echinococcus granulosus. J Parasit Dis. 2020;44(2):429-435.
Karimi Yazdi, M., Haniloo, A., Ghaffari, A., & Torabi, N. (2020). Antiparasitic effects of Zataria multiflora essential oil nano-emulsion on larval stages of Echinococcus granulosus. Journal of Parasitic Diseases : Official Organ of the Indian Society for Parasitology, 44(2), 429-435. https://doi.org/10.1007/s12639-020-01193-w
Karimi Yazdi M, et al. Antiparasitic Effects of Zataria Multiflora Essential Oil Nano-emulsion On Larval Stages of Echinococcus Granulosus. J Parasit Dis. 2020;44(2):429-435. PubMed PMID: 32508418.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antiparasitic effects of Zataria multiflora essential oil nano-emulsion on larval stages of Echinococcus granulosus. AU - Karimi Yazdi,Monire, AU - Haniloo,Ali, AU - Ghaffari,Azadeh, AU - Torabi,Negin, Y1 - 2020/01/13/ PY - 2019/10/06/received PY - 2020/01/03/accepted PY - 2021/06/01/pmc-release PY - 2020/6/9/entrez PY - 2020/6/9/pubmed PY - 2020/6/9/medline KW - Echinococcus granulosus KW - Emulsion KW - In vitro KW - Microcyst KW - Nano-emulsion KW - Protoscoleces KW - Zataria multiflora SP - 429 EP - 435 JF - Journal of parasitic diseases : official organ of the Indian Society for Parasitology JO - J Parasit Dis VL - 44 IS - 2 N2 - Various protoscolicidal agents are indicated for the prevention of recurrence of cystic echinococcosis caused by the larval stage of Echinococcus granulosus; however, most of these chemicals have adverse side effects. This study evaluated the effects of Zataria multiflora essential oil (ZEO) nano-emulsion and emulsion at the concentrations of 1, 2, 5, 10, 15, and 20 µl/ml on E. granulosus protoscoleces. Albendazole (5 mg/ml), normal saline, and nano-emulsion without ZEO served as control groups. Optimal concentrations of ZEO nano-emulsion and emulsion on the microcysts were also investigated. ZEO emulsion at a concentration of 20 µl/ml for the duration of 15 min and nano-emulsion for the duration of 10 min resulted in the death of 100% of the protoscoleces. Additionally, densely packed aggregates were formed inside the microcysts treated with ZEO nano-emulsion and emulsion at a concentration of 20 µl/ml after 40 min, but the complete destruction of laminated layers did not occur. The results indicate that ZEO nano-emulsions have a higher protoscolicidal effect than its emulsion, but these two compounds had similar effects on microcysts. SN - 0971-7196 UR - https://www.unboundmedicine.com/medline/citation/32508418/Antiparasitic_effects_of_Zataria_multiflora_essential_oil_nano-emulsion_on_larval_stages_of_Echinococcus_granulosus DB - PRIME DP - Unbound Medicine ER -
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