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De novo Gastrinoma: A Case Report.
GE Port J Gastroenterol. 2020 Apr; 27(3):192-196.GP

Abstract

Gastrinomas are neuroendocrine tumors characterized by gastrin overexpression - 80% are sporadic and 20% are associated with multiple endocrine neoplasia type 1. A 75-year-old male patient, surgically treated at the age of 50 years for gastrinoma, followed on an outpatient basis because of chronic non-bloody diarrhea, was admitted to our hospital because of abdominal pain, watery diarrhea, and nonbiliary vomits. He was hypotensive and showed no response to fluids. Blood cultures were positive for Salmonella, and a diagnosis of septic shock due to Salmonella infection was made. The patient's condition improved, but the history of chronic diarrhea was still not explained. To investigate chronic diarrhea, gastrinoma recurrence was considered. Serum gastrin measurement was five times higher than the upper limit of the normal range (536 pg/mL). A positive somatostatin receptor scintigraphy was diagnostic for neuroendocrine tumor. Metastases were excluded. The patient was proposed to curative surgery, and a diagnosis of a well-differentiated neuroendocrine tumor was made.

Authors+Show Affiliations

Internal Medicine Department, Centro Hospitalar São João, Porto, Portugal.Internal Medicine Department, Centro Hospitalar São João, Porto, Portugal.Internal Medicine Department, Centro Hospitalar São João, Porto, Portugal.Department of Anatomic Pathology, Centro Hospitalar São João, Porto, Portugal.Internal Medicine Department, Centro Hospitalar São João, Porto, Portugal.

Pub Type(s)

Case Reports

Language

eng

PubMed ID

32509925

Citation

Barbosa, Arsénio, et al. "De Novo Gastrinoma: a Case Report." GE Portuguese Journal of Gastroenterology, vol. 27, no. 3, 2020, pp. 192-196.
Barbosa A, Gomes F, Fonseca L, et al. De novo Gastrinoma: A Case Report. GE Port J Gastroenterol. 2020;27(3):192-196.
Barbosa, A., Gomes, F., Fonseca, L., Maia, T., & Almeida, J. (2020). De novo Gastrinoma: A Case Report. GE Portuguese Journal of Gastroenterology, 27(3), 192-196. https://doi.org/10.1159/000503073
Barbosa A, et al. De Novo Gastrinoma: a Case Report. GE Port J Gastroenterol. 2020;27(3):192-196. PubMed PMID: 32509925.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - De novo Gastrinoma: A Case Report. AU - Barbosa,Arsénio, AU - Gomes,Filipa, AU - Fonseca,Luísa, AU - Maia,Tiago, AU - Almeida,Jorge, Y1 - 2019/10/09/ PY - 2019/02/03/received PY - 2019/08/31/revised PY - 2020/6/9/entrez PY - 2020/6/9/pubmed PY - 2020/6/9/medline KW - Gastrinoma KW - Multiple endocrine neoplasia KW - Neuroendocrine tumor KW - Zollinger-Ellison syndrome SP - 192 EP - 196 JF - GE Portuguese journal of gastroenterology JO - GE Port J Gastroenterol VL - 27 IS - 3 N2 - Gastrinomas are neuroendocrine tumors characterized by gastrin overexpression - 80% are sporadic and 20% are associated with multiple endocrine neoplasia type 1. A 75-year-old male patient, surgically treated at the age of 50 years for gastrinoma, followed on an outpatient basis because of chronic non-bloody diarrhea, was admitted to our hospital because of abdominal pain, watery diarrhea, and nonbiliary vomits. He was hypotensive and showed no response to fluids. Blood cultures were positive for Salmonella, and a diagnosis of septic shock due to Salmonella infection was made. The patient's condition improved, but the history of chronic diarrhea was still not explained. To investigate chronic diarrhea, gastrinoma recurrence was considered. Serum gastrin measurement was five times higher than the upper limit of the normal range (536 pg/mL). A positive somatostatin receptor scintigraphy was diagnostic for neuroendocrine tumor. Metastases were excluded. The patient was proposed to curative surgery, and a diagnosis of a well-differentiated neuroendocrine tumor was made. SN - 2341-4545 UR - https://www.unboundmedicine.com/medline/citation/32509925/De_novo_Gastrinoma:_A_Case_Report L2 - https://www.karger.com?DOI=10.1159/000503073 DB - PRIME DP - Unbound Medicine ER -
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