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Atypical Ductal Hyperplasia on Ultrasonography-Guided Vacuum-Assisted Biopsy of the Breast: Considerations for Further Surgical Excision.
Ultrasound Q. 2020 Jun; 36(2):192-198.UQ

Abstract

The purposes of this study are to evaluate the upgrade rate of atypical ductal hyperplasia (ADH) diagnosed with ultrasonography (US)-guided vacuum-assisted biopsy (VAB) to malignancy and to identify the factors behind the underestimation. We retrospectively reviewed the pathologic results of US-guided VAB of the breast. A total of 50 ADH lesions that were surgically excised or with more than 12 months of follow-up were included. The upgrade rate of ADH was determined by dividing the number of lesions that were proven malignant on surgical excision by the total number of ADH diagnosed on VAB. Clinical, radiologic, procedural, and pathologic variables were analyzed to identify the factors behind the underestimation. The upgrade rate of ADH was found to be 16.0% (8/50 lesions). In univariable and multivariable analyses, the upgrade rates of ADH did not significantly differ among variables. In a subgroup analysis, according to history of breast cancer, the upgrade rates of ADH were significantly lower for lesions of mass than for lesions of nonmass (0% [0/23 lesions] vs 28.6% [4/14 lesions], P = 0.015), and for lesions without calcifications than for lesions with calcifications (0% [0/22 lesions] vs 26.7% [4/15 lesions], P = 0.021) in the negative history subgroup. ADH lesions in masses or without calcifications in patients without a family or personal history of breast cancer were associated with low upgrade rates. Thus, we suggest that ADH with these features can be followed rather than surgically excised after US-guided VAB.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Department of Radiology, Ilsan Paik Hospital, Inje University College of Medicine, Gimhae.

Department of Radiology, Severance Hospital, Research Institute of Radiological Science, Yonsei University College of Medicine, Seoul, South Korea.

Department of Radiology, Severance Hospital, Research Institute of Radiological Science, Yonsei University College of Medicine, Seoul, South Korea.

Department of Radiology, Severance Hospital, Research Institute of Radiological Science, Yonsei University College of Medicine, Seoul, South Korea.

Department of Radiology, Severance Hospital, Research Institute of Radiological Science, Yonsei University College of Medicine, Seoul, South Korea.

Department of Radiology, Severance Hospital, Research Institute of Radiological Science, Yonsei University College of Medicine, Seoul, South Korea.

Department of Radiology, Severance Hospital, Research Institute of Radiological Science, Yonsei University College of Medicine, Seoul, South Korea.

MeSH

AdolescentAdultAgedBreastBreast NeoplasmsCarcinoma, Intraductal, NoninfiltratingFemaleHumansImage-Guided BiopsyMiddle AgedRetrospective StudiesUltrasonography, InterventionalYoung Adult

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32511211

Citation

Kim, Ji Hee, et al. "Atypical Ductal Hyperplasia On Ultrasonography-Guided Vacuum-Assisted Biopsy of the Breast: Considerations for Further Surgical Excision." Ultrasound Quarterly, vol. 36, no. 2, 2020, pp. 192-198.

Kim JH, Han K, Kim MJ, et al. Atypical Ductal Hyperplasia on Ultrasonography-Guided Vacuum-Assisted Biopsy of the Breast: Considerations for Further Surgical Excision. Ultrasound Q. 2020;36(2):192-198.

Kim, J. H., Han, K., Kim, M. J., Moon, H. J., Yoon, J. H., Park, V. Y., & Kim, E. K. (2020). Atypical Ductal Hyperplasia on Ultrasonography-Guided Vacuum-Assisted Biopsy of the Breast: Considerations for Further Surgical Excision. Ultrasound Quarterly, 36(2), 192-198. https://doi.org/10.1097/RUQ.0000000000000478

Kim JH, et al. Atypical Ductal Hyperplasia On Ultrasonography-Guided Vacuum-Assisted Biopsy of the Breast: Considerations for Further Surgical Excision. Ultrasound Q. 2020;36(2):192-198. PubMed PMID: 32511211.

* Article titles in AMA citation format should be in sentence-case

TY - JOUR T1 - Atypical Ductal Hyperplasia on Ultrasonography-Guided Vacuum-Assisted Biopsy of the Breast: Considerations for Further Surgical Excision. AU - Kim,Ji Hee, AU - Han,Kyunghwa, AU - Kim,Min Jung, AU - Moon,Hee Jung, AU - Yoon,Jung Hyun, AU - Park,Vivian Youngjean, AU - Kim,Eun-Kyung, PY - 2020/6/9/entrez PY - 2020/6/9/pubmed PY - 2021/4/13/medline SP - 192 EP - 198 JF - Ultrasound quarterly JO - Ultrasound Q VL - 36 IS - 2 N2 - The purposes of this study are to evaluate the upgrade rate of atypical ductal hyperplasia (ADH) diagnosed with ultrasonography (US)-guided vacuum-assisted biopsy (VAB) to malignancy and to identify the factors behind the underestimation. We retrospectively reviewed the pathologic results of US-guided VAB of the breast. A total of 50 ADH lesions that were surgically excised or with more than 12 months of follow-up were included. The upgrade rate of ADH was determined by dividing the number of lesions that were proven malignant on surgical excision by the total number of ADH diagnosed on VAB. Clinical, radiologic, procedural, and pathologic variables were analyzed to identify the factors behind the underestimation. The upgrade rate of ADH was found to be 16.0% (8/50 lesions). In univariable and multivariable analyses, the upgrade rates of ADH did not significantly differ among variables. In a subgroup analysis, according to history of breast cancer, the upgrade rates of ADH were significantly lower for lesions of mass than for lesions of nonmass (0% [0/23 lesions] vs 28.6% [4/14 lesions], P = 0.015), and for lesions without calcifications than for lesions with calcifications (0% [0/22 lesions] vs 26.7% [4/15 lesions], P = 0.021) in the negative history subgroup. ADH lesions in masses or without calcifications in patients without a family or personal history of breast cancer were associated with low upgrade rates. Thus, we suggest that ADH with these features can be followed rather than surgically excised after US-guided VAB. SN - 1536-0253 UR - https://www.unboundmedicine.com/medline/citation/32511211/Atypical_Ductal_Hyperplasia_on_Ultrasonography_Guided_Vacuum_Assisted_Biopsy_of_the_Breast:_Considerations_for_Further_Surgical_Excision_ DB - PRIME DP - Unbound Medicine ER -