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SARS-CoV-2 infection: The role of cytokines in COVID-19 disease.
Cytokine Growth Factor Rev. 2020 08; 54:62-75.CG

Abstract

COVID-19 disease, caused by infection with SARS-CoV-2, is related to a series of physiopathological mechanisms that mobilize a wide variety of biomolecules, mainly immunological in nature. In the most severe cases, the prognosis can be markedly worsened by the hyperproduction of mainly proinflammatory cytokines, such as IL-1, IL-6, IL-12, IFN-γ, and TNF-α, preferentially targeting lung tissue. This study reviews published data on alterations in the expression of different cytokines in patients with COVID-19 who require admission to an intensive care unit. Data on the implication of cytokines in this disease and their effect on outcomes will support the design of more effective approaches to the management of COVID-19.

Authors+Show Affiliations

Biomedical Group (BIO277), Department of Nursing, Faculty of Health Sciences, University of Granada, Avda. Ilustración 60, 18016. Granada, Spain; Institute of Biosanitary Research, ibs.Granada, C/ Doctor Azpitarte 4, 4ª planta, 18012. Granada, Spain.Biomedical Group (BIO277), Department of Nursing, Faculty of Health Sciences, University of Granada, Avda. Ilustración 60, 18016. Granada, Spain; Institute of Biosanitary Research, ibs.Granada, C/ Doctor Azpitarte 4, 4ª planta, 18012. Granada, Spain.Hematology & Hemotherapy Unit. Universitary Hospital Virgen de las Nieves, Granada, Spain.Biomedical Group (BIO277), Department of Nursing, Faculty of Health Sciences, University of Granada, Avda. Ilustración 60, 18016. Granada, Spain; Institute of Biosanitary Research, ibs.Granada, C/ Doctor Azpitarte 4, 4ª planta, 18012. Granada, Spain; Institute of Neuroscience, University of Granada, Centro de Investigación Biomédica (CIBM). Parque de Tecnológico de la Salud (PTS) Avda. del Conocimiento S/N, 18016, Armilla, Granada, Spain. Electronic address: crr@ugr.es.Biomedical Group (BIO277), Department of Nursing, Faculty of Health Sciences, University of Granada, Avda. Ilustración 60, 18016. Granada, Spain; Institute of Biosanitary Research, ibs.Granada, C/ Doctor Azpitarte 4, 4ª planta, 18012. Granada, Spain.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32513566

Citation

Costela-Ruiz, Víctor J., et al. "SARS-CoV-2 Infection: the Role of Cytokines in COVID-19 Disease." Cytokine & Growth Factor Reviews, vol. 54, 2020, pp. 62-75.
Costela-Ruiz VJ, Illescas-Montes R, Puerta-Puerta JM, et al. SARS-CoV-2 infection: The role of cytokines in COVID-19 disease. Cytokine Growth Factor Rev. 2020;54:62-75.
Costela-Ruiz, V. J., Illescas-Montes, R., Puerta-Puerta, J. M., Ruiz, C., & Melguizo-Rodríguez, L. (2020). SARS-CoV-2 infection: The role of cytokines in COVID-19 disease. Cytokine & Growth Factor Reviews, 54, 62-75. https://doi.org/10.1016/j.cytogfr.2020.06.001
Costela-Ruiz VJ, et al. SARS-CoV-2 Infection: the Role of Cytokines in COVID-19 Disease. Cytokine Growth Factor Rev. 2020;54:62-75. PubMed PMID: 32513566.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - SARS-CoV-2 infection: The role of cytokines in COVID-19 disease. AU - Costela-Ruiz,Víctor J, AU - Illescas-Montes,Rebeca, AU - Puerta-Puerta,Jose M, AU - Ruiz,Concepción, AU - Melguizo-Rodríguez,Lucia, Y1 - 2020/06/02/ PY - 2020/05/19/received PY - 2020/05/19/revised PY - 2020/06/01/accepted PY - 2020/6/10/pubmed PY - 2020/9/29/medline PY - 2020/6/10/entrez KW - COVID-19 KW - Chemokines KW - Cytokine storm KW - Growth factors KW - SARS-CoV-2 SP - 62 EP - 75 JF - Cytokine & growth factor reviews JO - Cytokine Growth Factor Rev VL - 54 N2 - COVID-19 disease, caused by infection with SARS-CoV-2, is related to a series of physiopathological mechanisms that mobilize a wide variety of biomolecules, mainly immunological in nature. In the most severe cases, the prognosis can be markedly worsened by the hyperproduction of mainly proinflammatory cytokines, such as IL-1, IL-6, IL-12, IFN-γ, and TNF-α, preferentially targeting lung tissue. This study reviews published data on alterations in the expression of different cytokines in patients with COVID-19 who require admission to an intensive care unit. Data on the implication of cytokines in this disease and their effect on outcomes will support the design of more effective approaches to the management of COVID-19. SN - 1879-0305 UR - https://www.unboundmedicine.com/medline/citation/32513566/SARS_CoV_2_infection:_The_role_of_cytokines_in_COVID_19_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1359-6101(20)30109-X DB - PRIME DP - Unbound Medicine ER -