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Cannabis and multiple sclerosis.
Expert Rev Neurother. 2020 08; 20(8):849-854.ER

Abstract

INTRODUCTION

Patients with multiple sclerosis (MS) may suffer from spasticity and pain during their disease course. Baclofen, dantrolene, diazepam and gabapentin have been used as first-line options to treat these conditions, with modest results. Medical use of marijuana smoking has bypassed traditional clinical trials and has been legalized as a therapeutic option for MS-related spasticity and pain in some countries. Cannabis-derived drugs have been tested and approved for medical use.

AREAS COVERED

With the development of nabiximols by the pharmaceutical industry, more countries have made it possible for patients with MS to have legal access to cannabis-related therapies. The evidence-based data on nabiximols and MS-related spasticity, pain, and urinary symptoms is consistent. There are over 7,500 patients reported in 33 studies (12 from the United Kingdom and 11 from Italy).

EXPERT OPINION

Nabiximols is safe and effective for patients with MS whose spasticity could not be treated with the first-line oral drugs. At present, legislation, bureaucracy and costs involved in prescribing this drug limit the experience of neurologists from many countries. There is no scientific evidence that smoking marijuana can be beneficial to patients with MS.

Authors+Show Affiliations

Post-Graduate Program on Health and Environment, Universidade Metropolitana De Santos , Santos, Brazil. Department of Neurology, MS & Headache Research , Santos, Brazil.MS Section, Hospital Británico De CABA , Buenos Aires, Argentina.Departamento De Neurociencias Y Doctorado De Farmacologia, CUCS, Universidad De Guadalajara , Mexico.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32515670

Citation

Fragoso, Yara Dadalti, et al. "Cannabis and Multiple Sclerosis." Expert Review of Neurotherapeutics, vol. 20, no. 8, 2020, pp. 849-854.
Fragoso YD, Carra A, Macias MA. Cannabis and multiple sclerosis. Expert Rev Neurother. 2020;20(8):849-854.
Fragoso, Y. D., Carra, A., & Macias, M. A. (2020). Cannabis and multiple sclerosis. Expert Review of Neurotherapeutics, 20(8), 849-854. https://doi.org/10.1080/14737175.2020.1776610
Fragoso YD, Carra A, Macias MA. Cannabis and Multiple Sclerosis. Expert Rev Neurother. 2020;20(8):849-854. PubMed PMID: 32515670.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cannabis and multiple sclerosis. AU - Fragoso,Yara Dadalti, AU - Carra,Adriana, AU - Macias,Miguel Angel, Y1 - 2020/06/18/ PY - 2020/6/10/pubmed PY - 2021/5/18/medline PY - 2020/6/10/entrez KW - Multiple sclerosis KW - cannabis KW - legislation KW - nabiximols KW - pain KW - spasticity SP - 849 EP - 854 JF - Expert review of neurotherapeutics JO - Expert Rev Neurother VL - 20 IS - 8 N2 - INTRODUCTION: Patients with multiple sclerosis (MS) may suffer from spasticity and pain during their disease course. Baclofen, dantrolene, diazepam and gabapentin have been used as first-line options to treat these conditions, with modest results. Medical use of marijuana smoking has bypassed traditional clinical trials and has been legalized as a therapeutic option for MS-related spasticity and pain in some countries. Cannabis-derived drugs have been tested and approved for medical use. AREAS COVERED: With the development of nabiximols by the pharmaceutical industry, more countries have made it possible for patients with MS to have legal access to cannabis-related therapies. The evidence-based data on nabiximols and MS-related spasticity, pain, and urinary symptoms is consistent. There are over 7,500 patients reported in 33 studies (12 from the United Kingdom and 11 from Italy). EXPERT OPINION: Nabiximols is safe and effective for patients with MS whose spasticity could not be treated with the first-line oral drugs. At present, legislation, bureaucracy and costs involved in prescribing this drug limit the experience of neurologists from many countries. There is no scientific evidence that smoking marijuana can be beneficial to patients with MS. SN - 1744-8360 UR - https://www.unboundmedicine.com/medline/citation/32515670/Cannabis_and_multiple_sclerosis_ L2 - https://www.tandfonline.com/doi/full/10.1080/14737175.2020.1776610 DB - PRIME DP - Unbound Medicine ER -