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Levetiracetam induction of theta frequency oscillations in rodent hippocampus in vitro.
Can J Physiol Pharmacol. 2020 Jun 09 [Online ahead of print]CJ

Abstract

Levetiracetam(LEV) has been demonstrated to improve cognitive function. Hippocampal theta rhythm (4-12 Hz) is associated with a variety of cognitively related behaviors, such as exploration in both humans and animal models. We investigated the effects of LEV on the theta rhythm in the rat hippocampal CA3 in hippocampal slices in vitro. We found that LEV increased the theta power in a dose-dependent manner. The increase in theta power can be blocked by GABAA receptor(GABAAR) or NMDA receptor(NMDAR) antagonists but not by AMPA receptor antagonist, indicating the involvement of GABAAR and NMDAR in the induction of theta activity. Interestingly, LEV enhancement of theta power can be also blocked by taurine or GABA-A agonist THIP, indicating that LEV induction of theta may be related to the indirect boosting of GABA action via reduction of extrasynaptic GABAAR activation. Furthermore, the increased theta power can be partially reduced by mACh receptor(mAChR) antagonist atropine but not by nACh receptor antagonists, suggesting that mAChR activation provides excitatory input into local network responsible for LEV induced theta. Our study demonstrated that LEV induced a novel theta oscillation in vitro, which may have implications in treatment of the neuronal disorders with impaired theta oscillation and cognitive function.

Authors+Show Affiliations

Xinxiang Medical University, 91593, Xinxiang, Henan, China ; curtisxing@163.com.Xinxiang Medical University, 91593, Xinxiang, Henan, China ; 18912010@qq.com.Xinjiang Medical University, 74790, XINXIANG, Xinjiang, China ; sunny_1984@163.com.Xinxiang Medical University, 91593, Xinxiang, Henan, China ; SIHAO777@163.com.Xinxiang Medical University, 91593, Xinxiang, Henan, China ; JOHNLU9000@HOTMAIL.COM.Henan Provincial People's Hospital, 89632, Zhengzhou, China , 450003 ; hanxiong7589@126.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32516556

Citation

Xing, Hang, et al. "Levetiracetam Induction of Theta Frequency Oscillations in Rodent Hippocampus in Vitro." Canadian Journal of Physiology and Pharmacology, 2020.
Xing H, Xu S, Xie X, et al. Levetiracetam induction of theta frequency oscillations in rodent hippocampus in vitro. Can J Physiol Pharmacol. 2020.
Xing, H., Xu, S., Xie, X., Wang, Y., Lu, C., & Han, X. (2020). Levetiracetam induction of theta frequency oscillations in rodent hippocampus in vitro. Canadian Journal of Physiology and Pharmacology. https://doi.org/10.1139/cjpp-2019-0727
Xing H, et al. Levetiracetam Induction of Theta Frequency Oscillations in Rodent Hippocampus in Vitro. Can J Physiol Pharmacol. 2020 Jun 9; PubMed PMID: 32516556.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Levetiracetam induction of theta frequency oscillations in rodent hippocampus in vitro. AU - Xing,Hang, AU - Xu,Sihan, AU - Xie,Xin'e, AU - Wang,Yuan, AU - Lu,Chengbiao, AU - Han,Xiong, Y1 - 2020/06/09/ PY - 2020/6/10/entrez PY - 2020/6/10/pubmed PY - 2020/6/10/medline JF - Canadian journal of physiology and pharmacology JO - Can. J. Physiol. Pharmacol. N2 - Levetiracetam(LEV) has been demonstrated to improve cognitive function. Hippocampal theta rhythm (4-12 Hz) is associated with a variety of cognitively related behaviors, such as exploration in both humans and animal models. We investigated the effects of LEV on the theta rhythm in the rat hippocampal CA3 in hippocampal slices in vitro. We found that LEV increased the theta power in a dose-dependent manner. The increase in theta power can be blocked by GABAA receptor(GABAAR) or NMDA receptor(NMDAR) antagonists but not by AMPA receptor antagonist, indicating the involvement of GABAAR and NMDAR in the induction of theta activity. Interestingly, LEV enhancement of theta power can be also blocked by taurine or GABA-A agonist THIP, indicating that LEV induction of theta may be related to the indirect boosting of GABA action via reduction of extrasynaptic GABAAR activation. Furthermore, the increased theta power can be partially reduced by mACh receptor(mAChR) antagonist atropine but not by nACh receptor antagonists, suggesting that mAChR activation provides excitatory input into local network responsible for LEV induced theta. Our study demonstrated that LEV induced a novel theta oscillation in vitro, which may have implications in treatment of the neuronal disorders with impaired theta oscillation and cognitive function. SN - 1205-7541 UR - https://www.unboundmedicine.com/medline/citation/32516556/Levetiracetam_induction_of_theta_frequency_oscillations_in_rodent_hippocampus_in_vitro L2 - https://www.nrcresearchpress.com/doi/10.1139/cjpp-2019-0727?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -
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