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Pharmacological prevention of mood episodes in women with bipolar disorder during the perinatal period: A systematic review of current literature.
Asian J Psychiatr. 2020 May 12; 52:102145.AJ

Abstract

OBJECTIVE

This review examined the efficacy of mood stabilizers and antipsychotics in patients with bipolar disorder during pregnancy and the postpartum period.

METHODS

PubMed was searched for reports between 01 January 1996 and 31 December 2019 by using combinations of key words bipolar disorder, pregnancy, postpartum period, puerperium, prophylaxis, mood stabilizers, antipsychotics, lithium, lamotrigine, valproate, carbamazepine, oxcarbazepine, olanzapine, risperidone, quetiapine, aripiprazole, haloperidol, and chlorpromazine.

RESULTS

The present reports included a total of 256 patients using lithium (n = 143), lamotrigine (n = 73), valproate (n = 17), olanzapine (n = 17), quetiapine (n = 4) and haloperidol (n = 1) during pregnancy or the postpartum period. Recurrence rates in pregnant patients using lithium (n = 79) and lamotrigine (n = 17) were 22.7 % and 41.2 %, respectively. According to very limited data, none of the patients using valproate (n = 2), quetiapine (n = 3) or olanzapine (n = 6) experienced a new episode during pregnancy. A recurrence was reported in 12 (70.6 %) of 17 patients using valproate during the postpartum period. The same recurrence rates in patients using lithium (n = 123), lamotrigine (n = 63), olanzapine (n = 17) and quetiapine (n = 3) were 20.3 %, 7.9 %, 11.7 %, and 33.3 %, respectively.

CONCLUSIONS

This review suggests that lithium, lamotrigine and olanzapine seem to be effective in preventing new mood episodes in patients with bipolar disorder during the perinatal period.

Authors+Show Affiliations

Department of Psychiatry, Meram Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey. Electronic address: farukuguz@gmail.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32516746

Citation

Uguz, Faruk. "Pharmacological Prevention of Mood Episodes in Women With Bipolar Disorder During the Perinatal Period: a Systematic Review of Current Literature." Asian Journal of Psychiatry, vol. 52, 2020, p. 102145.
Uguz F. Pharmacological prevention of mood episodes in women with bipolar disorder during the perinatal period: A systematic review of current literature. Asian J Psychiatr. 2020;52:102145.
Uguz, F. (2020). Pharmacological prevention of mood episodes in women with bipolar disorder during the perinatal period: A systematic review of current literature. Asian Journal of Psychiatry, 52, 102145. https://doi.org/10.1016/j.ajp.2020.102145
Uguz F. Pharmacological Prevention of Mood Episodes in Women With Bipolar Disorder During the Perinatal Period: a Systematic Review of Current Literature. Asian J Psychiatr. 2020 May 12;52:102145. PubMed PMID: 32516746.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pharmacological prevention of mood episodes in women with bipolar disorder during the perinatal period: A systematic review of current literature. A1 - Uguz,Faruk, Y1 - 2020/05/12/ PY - 2020/02/11/received PY - 2020/04/27/revised PY - 2020/04/28/accepted PY - 2020/6/10/pubmed PY - 2020/6/10/medline PY - 2020/6/10/entrez KW - Bipolar disorder KW - Postpartum period KW - Pregnancy SP - 102145 EP - 102145 JF - Asian journal of psychiatry JO - Asian J Psychiatr VL - 52 N2 - OBJECTIVE: This review examined the efficacy of mood stabilizers and antipsychotics in patients with bipolar disorder during pregnancy and the postpartum period. METHODS: PubMed was searched for reports between 01 January 1996 and 31 December 2019 by using combinations of key words bipolar disorder, pregnancy, postpartum period, puerperium, prophylaxis, mood stabilizers, antipsychotics, lithium, lamotrigine, valproate, carbamazepine, oxcarbazepine, olanzapine, risperidone, quetiapine, aripiprazole, haloperidol, and chlorpromazine. RESULTS: The present reports included a total of 256 patients using lithium (n = 143), lamotrigine (n = 73), valproate (n = 17), olanzapine (n = 17), quetiapine (n = 4) and haloperidol (n = 1) during pregnancy or the postpartum period. Recurrence rates in pregnant patients using lithium (n = 79) and lamotrigine (n = 17) were 22.7 % and 41.2 %, respectively. According to very limited data, none of the patients using valproate (n = 2), quetiapine (n = 3) or olanzapine (n = 6) experienced a new episode during pregnancy. A recurrence was reported in 12 (70.6 %) of 17 patients using valproate during the postpartum period. The same recurrence rates in patients using lithium (n = 123), lamotrigine (n = 63), olanzapine (n = 17) and quetiapine (n = 3) were 20.3 %, 7.9 %, 11.7 %, and 33.3 %, respectively. CONCLUSIONS: This review suggests that lithium, lamotrigine and olanzapine seem to be effective in preventing new mood episodes in patients with bipolar disorder during the perinatal period. SN - 1876-2026 UR - https://www.unboundmedicine.com/medline/citation/32516746/Pharmacological_prevention_of_mood_episodes_in_women_with_bipolar_disorder_during_the_perinatal_period:_A_systematic_review_of_current_literature L2 - https://linkinghub.elsevier.com/retrieve/pii/S1876-2018(20)30256-2 DB - PRIME DP - Unbound Medicine ER -
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