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Effect of preoperative gabapentin after transurethral prostate resection under general anesthesia. A randomized double-blind, placebo-controlled trial.
Saudi Med J. 2020 Jun; 41(6):640-644.SM

Abstract

OBJECTIVES

To investigate whether preoperative oral gabapentin could reduce postoperative pain, analgesic consumption and the occurrence of catheter-related bladder discomfort (CRBD). Methods: In this study, participants randomly received either 600 mg gabapentin or placebo orally 2 h prior to transurethral prostate resection. Visual analogue scale and Ramsay sedation scale was utilized to assess pain intensity and sedation status after surgery. Intravenous 1.5 mg.kg-1 tramadol was used for postoperative analgesia. Pain intensity, sedation status, CRBD, tramadol consumption, side effects and the overall satisfaction degree were assessed and recorded for 48 h after tracheal extubation. Results: Ninety participants given gabapentin and 91 participants given placebo completed the study. Lower visual analogue scale scores, less tramadol consumption, longer time to the first analgesic requirement, lower incidence of CRBD and nausea and higher satisfaction degree were detected in the patients receiving gabapentin compared with the patients receiving placebo. Conclusion: Preoperative oral gabapentin reduced postoperative visual analogue scale scores, tramadol consumption and the occurrence rate of CRBD and nausea, and consequently, increased the degree of patients' satisfaction after transurethral prostate resection.

Authors+Show Affiliations

Department of Urology, The First Hospital of Jilin University, Jilin, China. E-mail. wangjinguolily@163.com.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32518932

Citation

Wang, Jinguo, et al. "Effect of Preoperative Gabapentin After Transurethral Prostate Resection Under General Anesthesia. a Randomized Double-blind, Placebo-controlled Trial." Saudi Medical Journal, vol. 41, no. 6, 2020, pp. 640-644.
Wang J, Fu G, Liu J, et al. Effect of preoperative gabapentin after transurethral prostate resection under general anesthesia. A randomized double-blind, placebo-controlled trial. Saudi Med J. 2020;41(6):640-644.
Wang, J., Fu, G., Liu, J., Yu, Y., & Wang, N. (2020). Effect of preoperative gabapentin after transurethral prostate resection under general anesthesia. A randomized double-blind, placebo-controlled trial. Saudi Medical Journal, 41(6), 640-644. https://doi.org/10.15537/smj.2020.6.25132
Wang J, et al. Effect of Preoperative Gabapentin After Transurethral Prostate Resection Under General Anesthesia. a Randomized Double-blind, Placebo-controlled Trial. Saudi Med J. 2020;41(6):640-644. PubMed PMID: 32518932.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of preoperative gabapentin after transurethral prostate resection under general anesthesia. A randomized double-blind, placebo-controlled trial. AU - Wang,Jinguo, AU - Fu,Guosheng, AU - Liu,Junyan, AU - Yu,Yunhai, AU - Wang,Na, PY - 2020/6/11/entrez SP - 640 EP - 644 JF - Saudi medical journal JO - Saudi Med J VL - 41 IS - 6 N2 - OBJECTIVES: To investigate whether preoperative oral gabapentin could reduce postoperative pain, analgesic consumption and the occurrence of catheter-related bladder discomfort (CRBD). Methods: In this study, participants randomly received either 600 mg gabapentin or placebo orally 2 h prior to transurethral prostate resection. Visual analogue scale and Ramsay sedation scale was utilized to assess pain intensity and sedation status after surgery. Intravenous 1.5 mg.kg-1 tramadol was used for postoperative analgesia. Pain intensity, sedation status, CRBD, tramadol consumption, side effects and the overall satisfaction degree were assessed and recorded for 48 h after tracheal extubation. Results: Ninety participants given gabapentin and 91 participants given placebo completed the study. Lower visual analogue scale scores, less tramadol consumption, longer time to the first analgesic requirement, lower incidence of CRBD and nausea and higher satisfaction degree were detected in the patients receiving gabapentin compared with the patients receiving placebo. Conclusion: Preoperative oral gabapentin reduced postoperative visual analogue scale scores, tramadol consumption and the occurrence rate of CRBD and nausea, and consequently, increased the degree of patients' satisfaction after transurethral prostate resection. SN - 0379-5284 UR - https://www.unboundmedicine.com/medline/citation/32518932/Effect_of_preoperative_gabapentin_after_transurethral_prostate_resection_under_general_anesthesia._A_randomized_double-blind,_placebo-controlled_trial L2 - https://doi.org/10.15537/smj.2020.6.25132 DB - PRIME DP - Unbound Medicine ER -
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