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Dermatologic conditions in Down syndrome: A single-center retrospective chart review.
Pediatr Dermatol. 2020 Jun 10 [Online ahead of print]PD

Abstract

BACKGROUND

Current literature addressing dermatologic conditions associated with Down syndrome is limited, with emphasis on rare skin conditions and lack of consensus on the incidence of more common disorders.

OBJECTIVE

We sought to evaluate dermatologic conditions in patients with Down syndrome diagnosed and managed by dermatologists.

METHODS

This was a retrospective analysis of 101 pediatric and adult patients with Down syndrome seen by the University of Massachusetts Dermatology Department between 2008 and 2018.

RESULTS

Folliculitis was the most common diagnosis overall (30.7%), followed by seborrheic dermatitis (26.7%) and hidradenitis suppurativa (22.8%). Eczematous dermatitis, alopecia areata, and xerosis were the most common diagnoses observed in children aged 0-12 years; hidradenitis suppurativa, folliculitis, and seborrheic dermatitis in adolescents aged 13-17 years; and folliculitis, seborrheic dermatitis, and xerosis in adults 18 years and older. Other notable diagnoses present overall included onychomycosis (9.9%) and psoriasis (8.9%). Malignant cutaneous tumors were present in two patients, specifically basal cell carcinoma and malignant melanoma in situ.

LIMITATIONS

This was a retrospective, single-institution study.

CONCLUSION

Dermatologic conditions in patients with Down syndrome vary by age but are most often adnexal and eczematous disorders. Trisomy of chromosome 21 and the resulting downstream effects, specifically on the immune system, may account for these findings.

Authors+Show Affiliations

Department of Dermatology, Dartmouth Medical School, Lebanon, NH, USA.University of Massachusetts Medical School, Worcester, MA, USA.Department of Dermatology, University of Massachusetts Medical School, Worcester, MA, USA.Department of Dermatology, University of Massachusetts Medical School, Worcester, MA, USA. Department of Pediatrics, University of Massachusetts Medical School, Worcester, MA, USA.Department of Dermatology, University of Massachusetts Medical School, Worcester, MA, USA. Department of Pediatrics, University of Massachusetts Medical School, Worcester, MA, USA.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32519435

Citation

Rork, Jillian F., et al. "Dermatologic Conditions in Down Syndrome: a Single-center Retrospective Chart Review." Pediatric Dermatology, 2020.
Rork JF, McCormack L, Lal K, et al. Dermatologic conditions in Down syndrome: A single-center retrospective chart review. Pediatr Dermatol. 2020.
Rork, J. F., McCormack, L., Lal, K., Wiss, K., & Belazarian, L. (2020). Dermatologic conditions in Down syndrome: A single-center retrospective chart review. Pediatric Dermatology. https://doi.org/10.1111/pde.14214
Rork JF, et al. Dermatologic Conditions in Down Syndrome: a Single-center Retrospective Chart Review. Pediatr Dermatol. 2020 Jun 10; PubMed PMID: 32519435.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dermatologic conditions in Down syndrome: A single-center retrospective chart review. AU - Rork,Jillian F, AU - McCormack,Lindsay, AU - Lal,Karan, AU - Wiss,Karen, AU - Belazarian,Leah, Y1 - 2020/06/10/ PY - 2019/12/30/received PY - 2020/04/22/revised PY - 2020/05/05/accepted PY - 2020/6/11/entrez KW - Down syndrome KW - alopecia areata KW - dermatologic conditions KW - dermatology KW - eczema KW - folliculitis KW - hidradenitis suppurativa KW - melanoma KW - onychomycosis KW - psoriasis KW - scabies KW - seborrheic dermatitis KW - skin KW - skin cancer KW - trisomy 21 KW - xerosis JF - Pediatric dermatology JO - Pediatr Dermatol N2 - BACKGROUND: Current literature addressing dermatologic conditions associated with Down syndrome is limited, with emphasis on rare skin conditions and lack of consensus on the incidence of more common disorders. OBJECTIVE: We sought to evaluate dermatologic conditions in patients with Down syndrome diagnosed and managed by dermatologists. METHODS: This was a retrospective analysis of 101 pediatric and adult patients with Down syndrome seen by the University of Massachusetts Dermatology Department between 2008 and 2018. RESULTS: Folliculitis was the most common diagnosis overall (30.7%), followed by seborrheic dermatitis (26.7%) and hidradenitis suppurativa (22.8%). Eczematous dermatitis, alopecia areata, and xerosis were the most common diagnoses observed in children aged 0-12 years; hidradenitis suppurativa, folliculitis, and seborrheic dermatitis in adolescents aged 13-17 years; and folliculitis, seborrheic dermatitis, and xerosis in adults 18 years and older. Other notable diagnoses present overall included onychomycosis (9.9%) and psoriasis (8.9%). Malignant cutaneous tumors were present in two patients, specifically basal cell carcinoma and malignant melanoma in situ. LIMITATIONS: This was a retrospective, single-institution study. CONCLUSION: Dermatologic conditions in patients with Down syndrome vary by age but are most often adnexal and eczematous disorders. Trisomy of chromosome 21 and the resulting downstream effects, specifically on the immune system, may account for these findings. SN - 1525-1470 UR - https://www.unboundmedicine.com/medline/citation/32519435/Dermatologic_conditions_in_Down_syndrome:_A_single-center_retrospective_chart_review L2 - https://doi.org/10.1111/pde.14214 DB - PRIME DP - Unbound Medicine ER -
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