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Effects of prenatal exposure to five parabens on neonatal thyroid function and birth weight: Evidence from SMBCS study.
Environ Res. 2020 Sep; 188:109710.ER

Abstract

BACKGROUND

Parabens, suspected as endocrine-disrupting chemicals, are nearly ubiquitous in the human body and exposure to these chemicals during pregnancy may disrupt thyroid hormones homeostasis and even affect fetal growth, although the impacts are still unclear.

OBJECTIVES

We aimed to estimate associations of maternal urinary paraben concentrations with cord serum thyroid hormones and birth weight.

METHODS

A subset of 437 mother-newborn pairs were included from a prospective birth cohort with five parabens quantified in maternal urine and seven thyroid function indicators measured in cord serum samples. Multivariable linear regression models and elastic net regression (ENR) models were applied to explore associations between individual and mixtures of prenatal urinary paraben concentrations and thyroid hormones and birth weight, respectively.

RESULTS

Maternal urinary ethyl-paraben (EtP) concentrations were associated with increased cord serum total triiodothyronine levels (TT3) [percent change: 1.51%; 95% confidence interval (CI): 0.20%, 2.74%; p=0.017]. Urinary propyl-paraben (PrP) levels predicted higher thyroid peroxidase antibodies (percent change: 4.19%, 95%CI: 0.20%, 8.44%; p=0.041). Maternal urinary EtP and butyl-paraben (BuP) concentrations were significantly positively associated with birth weight [regression coefficient, (β)=40.9g, 95%CI: 3.99, 76.6; p=0.030; β=62.1g, 95%CI: 8.70, 115; p=0.023, for EtP and BuP, respectively]. In sex-stratified analyses, positive relationship between EtP levels and birth weight was observed in boys. Urinary EtP concentrations predicted higher TT3 levels in cord serum samples, assessing parabens as a chemical mixture with ENR models.

CONCLUSIONS

Prenatal exposure to parabens may affect thyroid hormone indicators with increased serum TT3 levels and associate with higher birth weight, especially in boys. The underlying biological mechanisms and effects of prenatal paraben exposures on disruption of thyroid function homeostasis and potential impacts of childhood growth and development needed to be further investigated.

Authors+Show Affiliations

School of Public Health/ Key Laboratory of Public Health Safety of Ministry of Education/ Key Lab of Health Technology Assessment, National Health Commission of the People's Republic of China, Fudan University, No.130 Dong'an Road, Shanghai, 200032, China.School of Public Health/ Key Laboratory of Public Health Safety of Ministry of Education/ Key Lab of Health Technology Assessment, National Health Commission of the People's Republic of China, Fudan University, No.130 Dong'an Road, Shanghai, 200032, China.School of Public Health/ Key Laboratory of Public Health Safety of Ministry of Education/ Key Lab of Health Technology Assessment, National Health Commission of the People's Republic of China, Fudan University, No.130 Dong'an Road, Shanghai, 200032, China. Electronic address: chwu@shmu.edu.cn.School of Public Health/ Key Laboratory of Public Health Safety of Ministry of Education/ Key Lab of Health Technology Assessment, National Health Commission of the People's Republic of China, Fudan University, No.130 Dong'an Road, Shanghai, 200032, China.School of Public Health/ Key Laboratory of Public Health Safety of Ministry of Education/ Key Lab of Health Technology Assessment, National Health Commission of the People's Republic of China, Fudan University, No.130 Dong'an Road, Shanghai, 200032, China.School of Public Health/ Key Laboratory of Public Health Safety of Ministry of Education/ Key Lab of Health Technology Assessment, National Health Commission of the People's Republic of China, Fudan University, No.130 Dong'an Road, Shanghai, 200032, China.Shanghai Municipal Center for Disease Control and Prevention, No. 1380 Zhongshan West Road, Shanghai, 200336, China.Zhejiang Provincial Center for Disease Control and Prevention, No. 3399 Binsheng Road, Hangzhou, 310051, China.Shanghai Municipal Center for Disease Control and Prevention, No. 1380 Zhongshan West Road, Shanghai, 200336, China.Changning District Center for Disease Control and Prevention, No.39 Yunwushan Road, Shanghai, 200051, China.School of Public Health/ Key Laboratory of Public Health Safety of Ministry of Education/ Key Lab of Health Technology Assessment, National Health Commission of the People's Republic of China, Fudan University, No.130 Dong'an Road, Shanghai, 200032, China.School of Public Health/ Key Laboratory of Public Health Safety of Ministry of Education/ Key Lab of Health Technology Assessment, National Health Commission of the People's Republic of China, Fudan University, No.130 Dong'an Road, Shanghai, 200032, China.Changning District Center for Disease Control and Prevention, No.39 Yunwushan Road, Shanghai, 200051, China.Clinical Epidemiology and Biostatistics, School of Medical Sciences, Örebro University, Örebro, 70182, Sweden.Shanghai Municipal Center for Disease Control and Prevention, No. 1380 Zhongshan West Road, Shanghai, 200336, China.School of Public Health/ Key Laboratory of Public Health Safety of Ministry of Education/ Key Lab of Health Technology Assessment, National Health Commission of the People's Republic of China, Fudan University, No.130 Dong'an Road, Shanghai, 200032, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32521303

Citation

Li, Wenting, et al. "Effects of Prenatal Exposure to Five Parabens On Neonatal Thyroid Function and Birth Weight: Evidence From SMBCS Study." Environmental Research, vol. 188, 2020, p. 109710.
Li W, Guo J, Wu C, et al. Effects of prenatal exposure to five parabens on neonatal thyroid function and birth weight: Evidence from SMBCS study. Environ Res. 2020;188:109710.
Li, W., Guo, J., Wu, C., Zhang, J., Zhang, L., Lv, S., Lu, D., Qi, X., Feng, C., Liang, W., Chang, X., Zhang, Y., Xu, H., Cao, Y., Wang, G., & Zhou, Z. (2020). Effects of prenatal exposure to five parabens on neonatal thyroid function and birth weight: Evidence from SMBCS study. Environmental Research, 188, 109710. https://doi.org/10.1016/j.envres.2020.109710
Li W, et al. Effects of Prenatal Exposure to Five Parabens On Neonatal Thyroid Function and Birth Weight: Evidence From SMBCS Study. Environ Res. 2020;188:109710. PubMed PMID: 32521303.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of prenatal exposure to five parabens on neonatal thyroid function and birth weight: Evidence from SMBCS study. AU - Li,Wenting, AU - Guo,Jianqiu, AU - Wu,Chunhua, AU - Zhang,Jiming, AU - Zhang,Lei, AU - Lv,Shenliang, AU - Lu,Dasheng, AU - Qi,Xiaojuan, AU - Feng,Chao, AU - Liang,Weijiu, AU - Chang,Xiuli, AU - Zhang,Yubin, AU - Xu,Hao, AU - Cao,Yang, AU - Wang,Guoquan, AU - Zhou,Zhijun, Y1 - 2020/05/22/ PY - 2020/02/04/received PY - 2020/04/23/revised PY - 2020/05/19/accepted PY - 2020/6/11/pubmed PY - 2020/6/11/medline PY - 2020/6/11/entrez KW - Birth weight KW - Cord serum KW - Endocrine-disrupting chemicals KW - Parabens KW - Thyroid function SP - 109710 EP - 109710 JF - Environmental research JO - Environ. Res. VL - 188 N2 - BACKGROUND: Parabens, suspected as endocrine-disrupting chemicals, are nearly ubiquitous in the human body and exposure to these chemicals during pregnancy may disrupt thyroid hormones homeostasis and even affect fetal growth, although the impacts are still unclear. OBJECTIVES: We aimed to estimate associations of maternal urinary paraben concentrations with cord serum thyroid hormones and birth weight. METHODS: A subset of 437 mother-newborn pairs were included from a prospective birth cohort with five parabens quantified in maternal urine and seven thyroid function indicators measured in cord serum samples. Multivariable linear regression models and elastic net regression (ENR) models were applied to explore associations between individual and mixtures of prenatal urinary paraben concentrations and thyroid hormones and birth weight, respectively. RESULTS: Maternal urinary ethyl-paraben (EtP) concentrations were associated with increased cord serum total triiodothyronine levels (TT3) [percent change: 1.51%; 95% confidence interval (CI): 0.20%, 2.74%; p=0.017]. Urinary propyl-paraben (PrP) levels predicted higher thyroid peroxidase antibodies (percent change: 4.19%, 95%CI: 0.20%, 8.44%; p=0.041). Maternal urinary EtP and butyl-paraben (BuP) concentrations were significantly positively associated with birth weight [regression coefficient, (β)=40.9g, 95%CI: 3.99, 76.6; p=0.030; β=62.1g, 95%CI: 8.70, 115; p=0.023, for EtP and BuP, respectively]. In sex-stratified analyses, positive relationship between EtP levels and birth weight was observed in boys. Urinary EtP concentrations predicted higher TT3 levels in cord serum samples, assessing parabens as a chemical mixture with ENR models. CONCLUSIONS: Prenatal exposure to parabens may affect thyroid hormone indicators with increased serum TT3 levels and associate with higher birth weight, especially in boys. The underlying biological mechanisms and effects of prenatal paraben exposures on disruption of thyroid function homeostasis and potential impacts of childhood growth and development needed to be further investigated. SN - 1096-0953 UR - https://www.unboundmedicine.com/medline/citation/32521303/Effects_of_prenatal_exposure_to_five_parabens_on_neonatal_thyroid_function_and_birth_weight:_Evidence_from_SMBCS_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0013-9351(20)30603-4 DB - PRIME DP - Unbound Medicine ER -
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