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Use of personal protective equipment against coronavirus disease 2019 by healthcare professionals in Wuhan, China: cross sectional study.
BMJ. 2020 06 10; 369:m2195.BMJ

Abstract

OBJECTIVE

To examine the protective effects of appropriate personal protective equipment for frontline healthcare professionals who provided care for patients with coronavirus disease 2019 (covid-19).

DESIGN

Cross sectional study.

SETTING

Four hospitals in Wuhan, China.

PARTICIPANTS

420 healthcare professionals (116 doctors and 304 nurses) who were deployed to Wuhan by two affiliated hospitals of Sun Yat-sen University and Nanfang Hospital of Southern Medical University for 6-8 weeks from 24 January to 7 April 2020. These study participants were provided with appropriate personal protective equipment to deliver healthcare to patients admitted to hospital with covid-19 and were involved in aerosol generating procedures. 77 healthcare professionals with no exposure history to covid-19 and 80 patients who had recovered from covid-19 were recruited to verify the accuracy of antibody testing.

MAIN OUTCOME MEASURES

Covid-19 related symptoms (fever, cough, and dyspnoea) and evidence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, defined as a positive test for virus specific nucleic acids in nasopharyngeal swabs, or a positive test for IgM or IgG antibodies in the serum samples.

RESULTS

The average age of study participants was 35.8 years and 68.1% (286/420) were women. These study participants worked 4-6 hour shifts for an average of 5.4 days a week; they worked an average of 16.2 hours each week in intensive care units. All 420 study participants had direct contact with patients with covid-19 and performed at least one aerosol generating procedure. During the deployment period in Wuhan, none of the study participants reported covid-19 related symptoms. When the participants returned home, they all tested negative for SARS-CoV-2 specific nucleic acids and IgM or IgG antibodies (95% confidence interval 0.0 to 0.7%).

CONCLUSION

Before a safe and effective vaccine becomes available, healthcare professionals remain susceptible to covid-19. Despite being at high risk of exposure, study participants were appropriately protected and did not contract infection or develop protective immunity against SARS-CoV-2. Healthcare systems must give priority to the procurement and distribution of personal protective equipment, and provide adequate training to healthcare professionals in its use.

Authors+Show Affiliations

The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510080, China.The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510080, China.Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510080, China.The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510080, China.The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510080, China.The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510080, China.The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510080, China xiaohp@mail.sysu.edu.cn.Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510080, China.The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510080, China.Nan Fang Hospital, Southern Medical University, Guangzhou, China.Institute of Applied Health Research, University of Birmingham, Birmingham, UK.The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510080, China xiaohp@mail.sysu.edu.cn.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

32522737

Citation

Liu, Min, et al. "Use of Personal Protective Equipment Against Coronavirus Disease 2019 By Healthcare Professionals in Wuhan, China: Cross Sectional Study." BMJ (Clinical Research Ed.), vol. 369, 2020, pp. m2195.
Liu M, Cheng SZ, Xu KW, et al. Use of personal protective equipment against coronavirus disease 2019 by healthcare professionals in Wuhan, China: cross sectional study. BMJ. 2020;369:m2195.
Liu, M., Cheng, S. Z., Xu, K. W., Yang, Y., Zhu, Q. T., Zhang, H., Yang, D. Y., Cheng, S. Y., Xiao, H., Wang, J. W., Yao, H. R., Cong, Y. T., Zhou, Y. Q., Peng, S., Kuang, M., Hou, F. F., Cheng, K. K., & Xiao, H. P. (2020). Use of personal protective equipment against coronavirus disease 2019 by healthcare professionals in Wuhan, China: cross sectional study. BMJ (Clinical Research Ed.), 369, m2195. https://doi.org/10.1136/bmj.m2195
Liu M, et al. Use of Personal Protective Equipment Against Coronavirus Disease 2019 By Healthcare Professionals in Wuhan, China: Cross Sectional Study. BMJ. 2020 06 10;369:m2195. PubMed PMID: 32522737.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Use of personal protective equipment against coronavirus disease 2019 by healthcare professionals in Wuhan, China: cross sectional study. AU - Liu,Min, AU - Cheng,Shou-Zhen, AU - Xu,Ke-Wei, AU - Yang,Yang, AU - Zhu,Qing-Tang, AU - Zhang,Hui, AU - Yang,Da-Ya, AU - Cheng,Shu-Yuan, AU - Xiao,Han, AU - Wang,Ji-Wen, AU - Yao,He-Rui, AU - Cong,Yu-Tian, AU - Zhou,Yu-Qi, AU - Peng,Sui, AU - Kuang,Ming, AU - Hou,Fan-Fan, AU - Cheng,K K, AU - Xiao,Hai-Peng, Y1 - 2020/06/10/ PY - 2020/6/12/entrez PY - 2020/6/12/pubmed PY - 2020/6/20/medline SP - m2195 EP - m2195 JF - BMJ (Clinical research ed.) JO - BMJ VL - 369 N2 - OBJECTIVE: To examine the protective effects of appropriate personal protective equipment for frontline healthcare professionals who provided care for patients with coronavirus disease 2019 (covid-19). DESIGN: Cross sectional study. SETTING: Four hospitals in Wuhan, China. PARTICIPANTS: 420 healthcare professionals (116 doctors and 304 nurses) who were deployed to Wuhan by two affiliated hospitals of Sun Yat-sen University and Nanfang Hospital of Southern Medical University for 6-8 weeks from 24 January to 7 April 2020. These study participants were provided with appropriate personal protective equipment to deliver healthcare to patients admitted to hospital with covid-19 and were involved in aerosol generating procedures. 77 healthcare professionals with no exposure history to covid-19 and 80 patients who had recovered from covid-19 were recruited to verify the accuracy of antibody testing. MAIN OUTCOME MEASURES: Covid-19 related symptoms (fever, cough, and dyspnoea) and evidence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, defined as a positive test for virus specific nucleic acids in nasopharyngeal swabs, or a positive test for IgM or IgG antibodies in the serum samples. RESULTS: The average age of study participants was 35.8 years and 68.1% (286/420) were women. These study participants worked 4-6 hour shifts for an average of 5.4 days a week; they worked an average of 16.2 hours each week in intensive care units. All 420 study participants had direct contact with patients with covid-19 and performed at least one aerosol generating procedure. During the deployment period in Wuhan, none of the study participants reported covid-19 related symptoms. When the participants returned home, they all tested negative for SARS-CoV-2 specific nucleic acids and IgM or IgG antibodies (95% confidence interval 0.0 to 0.7%). CONCLUSION: Before a safe and effective vaccine becomes available, healthcare professionals remain susceptible to covid-19. Despite being at high risk of exposure, study participants were appropriately protected and did not contract infection or develop protective immunity against SARS-CoV-2. Healthcare systems must give priority to the procurement and distribution of personal protective equipment, and provide adequate training to healthcare professionals in its use. SN - 1756-1833 UR - https://www.unboundmedicine.com/medline/citation/32522737/Use_of_personal_protective_equipment_against_coronavirus_disease_2019_by_healthcare_professionals_in_Wuhan_China:_cross_sectional_study_ L2 - http://www.bmj.com/lookup/pmidlookup?view=long&pmid=32522737 DB - PRIME DP - Unbound Medicine ER -