Tags

Type your tag names separated by a space and hit enter

Therapeutic effects of HESA-A (a herbal-marine compound) in acute organophosphorus pesticide poisoning.
Avicenna J Phytomed. 2020 May-Jun; 10(3):235-242.AJ

Abstract

Objective

Organophosphorus compounds (OPs) are common causes of poisonings. Atropine and oximes are pharmacological antidotes of OPs. However, because of their adverse effects and insufficient performance, several other compounds have been evaluated as adjuvant therapy. HESA-A is a herbal-marine drug that contains material from Carum carvi (Persian cumin), Penaeus latisculatus (king prawn), and Apium graveolens (celery) with anti-inflammatory and antioxidants properties, which has shown useful effects as adjuvant therapy on some diseases. We have evaluated the effect of HESA-A on 69 moderate to severe acute OPs poisoned patients (44 HESA-A treated and 25 controls) as an adjuvant drug.

Materials and Methods

Two randomized age and sex matched groups of OPs poisoned patients were treated in Medical Toxicology Center of Imam Reza hospital, Mashhad, by conventional therapy with or without HESA-A (50 mg/kg/day orally). The evaluation criteria were total administrated doses of atropine and pralidoxime, intensive care unit (ICU) admission rate, mechanical respiration need, number of hospitalization days and mortality.

Results

There were no significant differences between the morbidity and mortality rate criteria of the two groups; moreover, we did not observe significant adverse effects for HESA-A.

Conclusion

HESA-A did not reduce morbidity and mortality of OPs poisoning and did not induce any major side effect in the patients.

Authors+Show Affiliations

Medical Toxicology Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.Medical Toxicology Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.Cutaneous Leishmaniasis Research Center, Emam Reza Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.Department of Forensic Medicine and Toxicology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.Medical Toxicology Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.Medical Toxicology and Drug Abuse Research Center, Birjand University of Medical Sciences, Birjand, Iran.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32523878

Citation

Mousavi, Seyed Reza, et al. "Therapeutic Effects of HESA-A (a Herbal-marine Compound) in Acute Organophosphorus Pesticide Poisoning." Avicenna Journal of Phytomedicine, vol. 10, no. 3, 2020, pp. 235-242.
Mousavi SR, Moshiri M, Darchini-Maragheh E, et al. Therapeutic effects of HESA-A (a herbal-marine compound) in acute organophosphorus pesticide poisoning. Avicenna J Phytomed. 2020;10(3):235-242.
Mousavi, S. R., Moshiri, M., Darchini-Maragheh, E., Ghasempouri, S. K., Dadpour, B., Sardar Antighechi, F., & Balali-Mood, M. (2020). Therapeutic effects of HESA-A (a herbal-marine compound) in acute organophosphorus pesticide poisoning. Avicenna Journal of Phytomedicine, 10(3), 235-242.
Mousavi SR, et al. Therapeutic Effects of HESA-A (a Herbal-marine Compound) in Acute Organophosphorus Pesticide Poisoning. Avicenna J Phytomed. 2020 May-Jun;10(3):235-242. PubMed PMID: 32523878.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Therapeutic effects of HESA-A (a herbal-marine compound) in acute organophosphorus pesticide poisoning. AU - Mousavi,Seyed Reza, AU - Moshiri,Mohammad, AU - Darchini-Maragheh,Emadodin, AU - Ghasempouri,Seyed Khosro, AU - Dadpour,Bita, AU - Sardar Antighechi,Faezeh, AU - Balali-Mood,Mahdi, PY - 2020/6/12/entrez PY - 2020/6/12/pubmed PY - 2020/6/12/medline KW - Clinical trial KW - HESA-A KW - Organophosphorus pesticides Poisoning SP - 235 EP - 242 JF - Avicenna journal of phytomedicine JO - Avicenna J Phytomed VL - 10 IS - 3 N2 - Objective: Organophosphorus compounds (OPs) are common causes of poisonings. Atropine and oximes are pharmacological antidotes of OPs. However, because of their adverse effects and insufficient performance, several other compounds have been evaluated as adjuvant therapy. HESA-A is a herbal-marine drug that contains material from Carum carvi (Persian cumin), Penaeus latisculatus (king prawn), and Apium graveolens (celery) with anti-inflammatory and antioxidants properties, which has shown useful effects as adjuvant therapy on some diseases. We have evaluated the effect of HESA-A on 69 moderate to severe acute OPs poisoned patients (44 HESA-A treated and 25 controls) as an adjuvant drug. Materials and Methods: Two randomized age and sex matched groups of OPs poisoned patients were treated in Medical Toxicology Center of Imam Reza hospital, Mashhad, by conventional therapy with or without HESA-A (50 mg/kg/day orally). The evaluation criteria were total administrated doses of atropine and pralidoxime, intensive care unit (ICU) admission rate, mechanical respiration need, number of hospitalization days and mortality. Results: There were no significant differences between the morbidity and mortality rate criteria of the two groups; moreover, we did not observe significant adverse effects for HESA-A. Conclusion: HESA-A did not reduce morbidity and mortality of OPs poisoning and did not induce any major side effect in the patients. SN - 2228-7930 UR - https://www.unboundmedicine.com/medline/citation/32523878/Therapeutic_effects_of_HESA-A_(a_herbal-marine_compound)_in_acute_organophosphorus_pesticide_poisoning L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/32523878/ DB - PRIME DP - Unbound Medicine ER -
Try the Free App:
Prime PubMed app for iOS iPhone iPad
Prime PubMed app for Android
Prime PubMed is provided
free to individuals by:
Unbound Medicine.