Tags

Type your tag names separated by a space and hit enter

Analysis of the Hosts and Transmission Paths of SARS-CoV-2 in the COVID-19 Outbreak.
Genes (Basel). 2020 06 09; 11(6)G

Abstract

The severe respiratory disease COVID-19 was initially reported in Wuhan, China, in December 2019, and spread into many provinces from Wuhan. The corresponding pathogen was soon identified as a novel coronavirus named SARS-CoV-2 (formerly, 2019-nCoV). As of 2 May, 2020, over 3 million COVID-19 cases had been confirmed, and 235,290 deaths had been reported globally, and the numbers are still increasing. It is important to understand the phylogenetic relationship between SARS-CoV-2 and known coronaviruses, and to identify its hosts for preventing the next round of emergency outbreak. In this study, we employ an effective alignment-free approach, the Natural Vector method, to analyze the phylogeny and classify the coronaviruses based on genomic and protein data. Our results show that SARS-CoV-2 is closely related to, but distinct from the SARS-CoV branch. By analyzing the genetic distances from the SARS-CoV-2 strain to the coronaviruses residing in animal hosts, we establish that the most possible transmission path originates from bats to pangolins to humans.

Authors+Show Affiliations

Department of Mathematical Sciences, Tsinghua University, Beijing 100084, China.Department of Mathematical Sciences, Tsinghua University, Beijing 100084, China.Department of Mathematics, Statistics and Computer Science, University of Illinois at Chicago, Chicago, IL 60607, USA.Department of Biological Sciences, Chicago State University, Chicago, IL 60628, USA.Department of Mathematical Sciences, Tsinghua University, Beijing 100084, China.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

32526937

Citation

Dong, Rui, et al. "Analysis of the Hosts and Transmission Paths of SARS-CoV-2 in the COVID-19 Outbreak." Genes, vol. 11, no. 6, 2020.
Dong R, Pei S, Yin C, et al. Analysis of the Hosts and Transmission Paths of SARS-CoV-2 in the COVID-19 Outbreak. Genes (Basel). 2020;11(6).
Dong, R., Pei, S., Yin, C., He, R. L., & Yau, S. S. (2020). Analysis of the Hosts and Transmission Paths of SARS-CoV-2 in the COVID-19 Outbreak. Genes, 11(6). https://doi.org/10.3390/genes11060637
Dong R, et al. Analysis of the Hosts and Transmission Paths of SARS-CoV-2 in the COVID-19 Outbreak. Genes (Basel). 2020 06 9;11(6) PubMed PMID: 32526937.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Analysis of the Hosts and Transmission Paths of SARS-CoV-2 in the COVID-19 Outbreak. AU - Dong,Rui, AU - Pei,Shaojun, AU - Yin,Changchuan, AU - He,Rong Lucy, AU - Yau,Stephen S-T, Y1 - 2020/06/09/ PY - 2020/03/29/received PY - 2020/05/30/revised PY - 2020/06/03/accepted PY - 2020/6/13/entrez PY - 2020/6/13/pubmed PY - 2020/6/20/medline KW - COVID-19 KW - Natural Vector method KW - SARS-CoV-2 KW - transmission path JF - Genes JO - Genes (Basel) VL - 11 IS - 6 N2 - The severe respiratory disease COVID-19 was initially reported in Wuhan, China, in December 2019, and spread into many provinces from Wuhan. The corresponding pathogen was soon identified as a novel coronavirus named SARS-CoV-2 (formerly, 2019-nCoV). As of 2 May, 2020, over 3 million COVID-19 cases had been confirmed, and 235,290 deaths had been reported globally, and the numbers are still increasing. It is important to understand the phylogenetic relationship between SARS-CoV-2 and known coronaviruses, and to identify its hosts for preventing the next round of emergency outbreak. In this study, we employ an effective alignment-free approach, the Natural Vector method, to analyze the phylogeny and classify the coronaviruses based on genomic and protein data. Our results show that SARS-CoV-2 is closely related to, but distinct from the SARS-CoV branch. By analyzing the genetic distances from the SARS-CoV-2 strain to the coronaviruses residing in animal hosts, we establish that the most possible transmission path originates from bats to pangolins to humans. SN - 2073-4425 UR - https://www.unboundmedicine.com/medline/citation/32526937/Analysis_of_the_Hosts_and_Transmission_Paths_of_SARS_CoV_2_in_the_COVID_19_Outbreak_ L2 - https://www.mdpi.com/resolver?pii=genes11060637 DB - PRIME DP - Unbound Medicine ER -