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Prevalence and Recovery From Olfactory and Gustatory Dysfunctions in Covid-19 Infection: A Prospective Multicenter Study.
Am J Rhinol Allergy. 2020 Sep; 34(5):686-693.AJ

Abstract

BACKGROUND

Covid-19 is defined by an association of multiple symptoms, including frequently reported olfactory and gustatory disorders.

OBJECTIVE

The main purpose of this study was to analyze the prevalence of these neurosensory impairments in patients with Covid-19, and to assess short-term recovery.

METHODS

We performed a multicenter case series study during the Covid-19 epidemic. All patients presenting a RT-PCR-confirmed SARS-CoV-2 infection were included, whether hospitalized or treated at home. To analyze the prevalence and features of olfactory and gustatory dysfunctions, a phone interview was conducted 5 days after the positive PCR result. The questionnaire was submitted again 10 days later to patients having reported olfactory and gustatory disorders, in order to assess their recovery.

RESULTS

115 patients were included in our study. 81 patients (70%) reported olfactory and gustatory disorders without nasal obstruction or rhinorrhea. These impairments were more frequently reported in the female population, young people, and house-bound patients with mild symptomatic forms. Short-term recovery assessed at Day 15 was complete for 64% of the patients, and incomplete in 33%. Median recovery time was 15 days (4-27 days) after olfactory or gustatory symptom onset.

CONCLUSION

Olfactory and gustatory dysfunctions related to Covid-19 are frequently reported and prevalent in mild symptomatic forms of the disease. Recovery in most cases seems rapid and complete.

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Authors+Show Affiliations

Chary E
ORL-Head and Neck Surgery, University Hospital of Poitiers, Poitiers, France.
Carsuzaa F
ORL-Head and Neck Surgery, University Hospital of Poitiers, Poitiers, France.
Trijolet JP
ORL-Head and Neck Surgery, Saint Louis Hospital, La Rochelle, France.
Capitaine AL
ORL-Head and Neck Surgery, Saint Louis Hospital, La Rochelle, France.
Roncato-Saberan M
Infectious Diseases, Saint Louis Hospital, La Rochelle, France.
Fouet K
Infectious Diseases, Saint Louis Hospital, La Rochelle, France.
Cazenave-Roblot F
Infectious Diseases, University Hospital of Poitiers, Poitiers, France.
Catroux M
Infectious Diseases, University Hospital of Poitiers, Poitiers, France.
Allix-Beguec C
Clinical Research Department, Saint Louis Hospital, La Rochelle, France.
Dufour X
ORL-Head and Neck Surgery, University Hospital of Poitiers, Poitiers, France.

MeSH

AdultAgedAged, 80 and overBetacoronavirusCOVID-19Coronavirus InfectionsFemaleFollow-Up StudiesFranceHumansMaleMiddle AgedOlfaction DisordersOlfactory PerceptionPandemicsPneumonia, ViralPrevalenceProspective StudiesRecovery of FunctionSARS-CoV-2Taste DisordersTaste PerceptionYoung Adult

Pub Type(s)

Journal Article
Multicenter Study

Language

eng

PubMed ID

32527141

Citation

Chary, Eléonore, et al. "Prevalence and Recovery From Olfactory and Gustatory Dysfunctions in Covid-19 Infection: a Prospective Multicenter Study." American Journal of Rhinology & Allergy, vol. 34, no. 5, 2020, pp. 686-693.
Chary E, Carsuzaa F, Trijolet JP, et al. Prevalence and Recovery From Olfactory and Gustatory Dysfunctions in Covid-19 Infection: A Prospective Multicenter Study. Am J Rhinol Allergy. 2020;34(5):686-693.
Chary, E., Carsuzaa, F., Trijolet, J. P., Capitaine, A. L., Roncato-Saberan, M., Fouet, K., Cazenave-Roblot, F., Catroux, M., Allix-Beguec, C., & Dufour, X. (2020). Prevalence and Recovery From Olfactory and Gustatory Dysfunctions in Covid-19 Infection: A Prospective Multicenter Study. American Journal of Rhinology & Allergy, 34(5), 686-693. https://doi.org/10.1177/1945892420930954
Chary E, et al. Prevalence and Recovery From Olfactory and Gustatory Dysfunctions in Covid-19 Infection: a Prospective Multicenter Study. Am J Rhinol Allergy. 2020;34(5):686-693. PubMed PMID: 32527141.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence and Recovery From Olfactory and Gustatory Dysfunctions in Covid-19 Infection: A Prospective Multicenter Study. AU - Chary,Eléonore, AU - Carsuzaa,Florent, AU - Trijolet,Jean-Paul, AU - Capitaine,Anne-Laure, AU - Roncato-Saberan,Mariam, AU - Fouet,Kevin, AU - Cazenave-Roblot,France, AU - Catroux,Mélanie, AU - Allix-Beguec,Caroline, AU - Dufour,Xavier, Y1 - 2020/06/12/ PY - 2020/6/13/pubmed PY - 2020/8/22/medline PY - 2020/6/13/entrez KW - Ageusia KW - Anosmia KW - Covid-19 KW - Gustatory disorders KW - Olfactory disorders KW - Recovery KW - SARS-CoV-2 SP - 686 EP - 693 JF - American journal of rhinology & allergy JO - Am J Rhinol Allergy VL - 34 IS - 5 N2 - BACKGROUND: Covid-19 is defined by an association of multiple symptoms, including frequently reported olfactory and gustatory disorders. OBJECTIVE: The main purpose of this study was to analyze the prevalence of these neurosensory impairments in patients with Covid-19, and to assess short-term recovery. METHODS: We performed a multicenter case series study during the Covid-19 epidemic. All patients presenting a RT-PCR-confirmed SARS-CoV-2 infection were included, whether hospitalized or treated at home. To analyze the prevalence and features of olfactory and gustatory dysfunctions, a phone interview was conducted 5 days after the positive PCR result. The questionnaire was submitted again 10 days later to patients having reported olfactory and gustatory disorders, in order to assess their recovery. RESULTS: 115 patients were included in our study. 81 patients (70%) reported olfactory and gustatory disorders without nasal obstruction or rhinorrhea. These impairments were more frequently reported in the female population, young people, and house-bound patients with mild symptomatic forms. Short-term recovery assessed at Day 15 was complete for 64% of the patients, and incomplete in 33%. Median recovery time was 15 days (4-27 days) after olfactory or gustatory symptom onset. CONCLUSION: Olfactory and gustatory dysfunctions related to Covid-19 are frequently reported and prevalent in mild symptomatic forms of the disease. Recovery in most cases seems rapid and complete. SN - 1945-8932 UR - https://www.unboundmedicine.com/medline/citation/32527141/Prevalence_and_Recovery_From_Olfactory_and_Gustatory_Dysfunctions_in_Covid_19_Infection:_A_Prospective_Multicenter_Study_ DB - PRIME DP - Unbound Medicine ER -