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Aniba canelilla (Kunth) Mez (Lauraceae): A Review of Ethnobotany, Phytochemical, Antioxidant, Anti-Inflammatory, Cardiovascular, and Neurological Properties.
Front Pharmacol. 2020; 11:699.FP

Abstract

Aniba canelilla (Kunth) Mez, popularly known as "casca preciosa" (precious bark), falsa canela (cinnamon-scented) Casca-do-maranhão (bark of maranhão), and Folha-preciosa (precious leaf), is an aromatic species of the Lauraceae family, widely distributed in the Amazon region. In traditional medicine, it is indicated for the treatment of a great diversity of diseases, including digestive, respiratory, inflam]matory, painful, and central nervous system disorders, it is administered mainly in the form of tea or decoction orally. Its essential oil is referred to as a natural antioxidant for food preservation and disease control, showing great potential for use in the cosmetics, perfumery, and pharmaceutical products sector. The present review aimed to discuss critically and comprehensively the ethnobotanical characteristics, phytochemical constitution, and scientifically tested biological properties of A. canelilla, systematizing the knowledge about the species and proposing new perspectives for research and development. The chemical composition of A. canelilla includes 1-nitro-2-phenylethane, metyleugenol, eugenol, safrol, anabasin, anbin, tannin, α-pinene, b-pinene, b-felandren, b-caryophyllene, b-sesquifelandren, p-cymene, linalool, α-copaene, and spatulenol. Researches with ethanolic extracts, essential oils, and major constituents (1-nitro-2-phenylethane and metyleugenol) have revealed antioxidant, antinociceptive, anti-inflammatory, cardio-modulating, hypotensive (vasorelaxant), hypnotic, anxiolytic, anticholinesterase, and antibiotic properties (trypanomicidal, leishmanicidal, and antifungal). Some of these effects are potentially beneficial for aging-related diseases treatment, such as cardio and cerebrovascular, chronic inflammatory, neurological, and degenerative diseases. However, it is necessary to advance in the research of its clinical use and development of therapeutic products.

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Authors+Show Affiliations

Souza-Junior FJC
Laboratório de Farmacologia da Inflamação e do Comportamento, Universidade Federal do Pará, Belém-PA, Brazil.
Luz-Moraes D
Laboratório de Farmacologia da Inflamação e do Comportamento, Universidade Federal do Pará, Belém-PA, Brazil. Programa de Pós-Graduação em Ciências Farmacêuticas, Instituto de Ciências da Saúde, Universidade Federal do Pará, Belém-PA, Brazil.
Pereira FS
Laboratório de Farmacologia da Inflamação e do Comportamento, Universidade Federal do Pará, Belém-PA, Brazil. Programa de Pós-Graduação em Ciências Farmacêuticas, Instituto de Ciências da Saúde, Universidade Federal do Pará, Belém-PA, Brazil.
Barros MA
Laboratório de Farmacologia da Inflamação e do Comportamento, Universidade Federal do Pará, Belém-PA, Brazil.
Fernandes LMP
Laboratório de Farmacologia da Inflamação e do Comportamento, Universidade Federal do Pará, Belém-PA, Brazil.
Queiroz LY
Laboratório de Farmacologia da Inflamação e do Comportamento, Universidade Federal do Pará, Belém-PA, Brazil.
Maia CF
Laboratório de Farmacologia da Inflamação e do Comportamento, Universidade Federal do Pará, Belém-PA, Brazil. Programa de Pós-Graduação em Ciências Farmacêuticas, Instituto de Ciências da Saúde, Universidade Federal do Pará, Belém-PA, Brazil.
Maia JGS
Programa de Pós-Graduação em Ciências Farmacêuticas, Instituto de Ciências da Saúde, Universidade Federal do Pará, Belém-PA, Brazil.
Fontes-Junior EA
Laboratório de Farmacologia da Inflamação e do Comportamento, Universidade Federal do Pará, Belém-PA, Brazil. Programa de Pós-Graduação em Ciências Farmacêuticas, Instituto de Ciências da Saúde, Universidade Federal do Pará, Belém-PA, Brazil.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32528283

Citation

Souza-Junior, Fabio J C., et al. "Aniba Canelilla (Kunth) Mez (Lauraceae): a Review of Ethnobotany, Phytochemical, Antioxidant, Anti-Inflammatory, Cardiovascular, and Neurological Properties." Frontiers in Pharmacology, vol. 11, 2020, p. 699.
Souza-Junior FJC, Luz-Moraes D, Pereira FS, et al. Aniba canelilla (Kunth) Mez (Lauraceae): A Review of Ethnobotany, Phytochemical, Antioxidant, Anti-Inflammatory, Cardiovascular, and Neurological Properties. Front Pharmacol. 2020;11:699.
Souza-Junior, F. J. C., Luz-Moraes, D., Pereira, F. S., Barros, M. A., Fernandes, L. M. P., Queiroz, L. Y., Maia, C. F., Maia, J. G. S., & Fontes-Junior, E. A. (2020). Aniba canelilla (Kunth) Mez (Lauraceae): A Review of Ethnobotany, Phytochemical, Antioxidant, Anti-Inflammatory, Cardiovascular, and Neurological Properties. Frontiers in Pharmacology, 11, 699. https://doi.org/10.3389/fphar.2020.00699
Souza-Junior FJC, et al. Aniba Canelilla (Kunth) Mez (Lauraceae): a Review of Ethnobotany, Phytochemical, Antioxidant, Anti-Inflammatory, Cardiovascular, and Neurological Properties. Front Pharmacol. 2020;11:699. PubMed PMID: 32528283.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Aniba canelilla (Kunth) Mez (Lauraceae): A Review of Ethnobotany, Phytochemical, Antioxidant, Anti-Inflammatory, Cardiovascular, and Neurological Properties. AU - Souza-Junior,Fabio J C, AU - Luz-Moraes,Daniele, AU - Pereira,Felype S, AU - Barros,Mayra A, AU - Fernandes,Luanna M P, AU - Queiroz,Letícia Y, AU - Maia,Cristiane F, AU - Maia,José Guilherme S, AU - Fontes-Junior,Enéas A, Y1 - 2020/05/26/ PY - 2019/12/02/received PY - 2020/04/28/accepted PY - 2020/6/13/entrez PY - 2020/6/13/pubmed PY - 2020/6/13/medline KW - 1-nitro-2-phenylethane KW - Aniba canelilla (Kunth) Mez KW - biological activities KW - folk medicine KW - methyleugenol KW - toxicity SP - 699 EP - 699 JF - Frontiers in pharmacology JO - Front Pharmacol VL - 11 N2 - Aniba canelilla (Kunth) Mez, popularly known as "casca preciosa" (precious bark), falsa canela (cinnamon-scented) Casca-do-maranhão (bark of maranhão), and Folha-preciosa (precious leaf), is an aromatic species of the Lauraceae family, widely distributed in the Amazon region. In traditional medicine, it is indicated for the treatment of a great diversity of diseases, including digestive, respiratory, inflam]matory, painful, and central nervous system disorders, it is administered mainly in the form of tea or decoction orally. Its essential oil is referred to as a natural antioxidant for food preservation and disease control, showing great potential for use in the cosmetics, perfumery, and pharmaceutical products sector. The present review aimed to discuss critically and comprehensively the ethnobotanical characteristics, phytochemical constitution, and scientifically tested biological properties of A. canelilla, systematizing the knowledge about the species and proposing new perspectives for research and development. The chemical composition of A. canelilla includes 1-nitro-2-phenylethane, metyleugenol, eugenol, safrol, anabasin, anbin, tannin, α-pinene, b-pinene, b-felandren, b-caryophyllene, b-sesquifelandren, p-cymene, linalool, α-copaene, and spatulenol. Researches with ethanolic extracts, essential oils, and major constituents (1-nitro-2-phenylethane and metyleugenol) have revealed antioxidant, antinociceptive, anti-inflammatory, cardio-modulating, hypotensive (vasorelaxant), hypnotic, anxiolytic, anticholinesterase, and antibiotic properties (trypanomicidal, leishmanicidal, and antifungal). Some of these effects are potentially beneficial for aging-related diseases treatment, such as cardio and cerebrovascular, chronic inflammatory, neurological, and degenerative diseases. However, it is necessary to advance in the research of its clinical use and development of therapeutic products. SN - 1663-9812 UR - https://www.unboundmedicine.com/medline/citation/32528283/Aniba_canelilla__Kunth__Mez__Lauraceae_:_A_Review_of_Ethnobotany_Phytochemical_Antioxidant_Anti_Inflammatory_Cardiovascular_and_Neurological_Properties_ DB - PRIME DP - Unbound Medicine ER -